芳基氨甲基-哌啶/四氢萘类μ/δ阿片受体双重功效镇痛分子成药性研究

81773635
2017
H3407.药物设计与药物信息
付伟
面上项目
教授
复旦大学
48万元
μ/δ双重功效阿片配基;成药性研究;阿片类镇痛药;G蛋白功能偏向型配基;低毒副作用
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
重置
序号 标题 类型 作者
1 Design, Synthesis, and Structure–Activity Relationship Studies of Novel Indolyalkylpiperazine Derivatives as Selective 5-HT1A Receptor Agonists 期刊论文 Wenli Wang;Lan Zheng;Wei Li;Chen Zhu;Weiqing Peng;Bing Han;Wei Fu
2 Discovery of aryl-piperidine derivatives as potential antipsychotic agents using molecular hybridization strategy 期刊论文 Chen Zhu;Xinwei Li;Bangyi Zhao;Weiqing Peng;Wei Li;Wei Fu
3 Design, Synthesis, and Structure−Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists 期刊论文 Huoming Huang;Xinwei Li;Wei Guo;Chen Zhu;Yuanyuan Qian;Qing Shen;Xuejun X;Wei Li;Yujun Wang;Wei Fu
4 3-(二甲氨基甲基)哌啶-4-醇衍生物及其制备方法和药物用途 专利 付伟;黄火明
5 一类阿片受体激动剂及其制备方法和药物用途 专利 付伟
6 iscovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic 期刊论文 Huoming Huang;Xueping Li;Peng Xie;Xinwei Li;XueJun Xu;Yuanyuan Qian;Congmin Yuan;Xiangguo Meng;JingRui Chai;Jing Chen;Jing Liu;Wenli Wang;Wei Li;YuJun Wang;Wei Fu
7 Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases 期刊论文 Nannan Sun;Xiaojun Ma;Kaifeng Zhou;Chen Zhu;Zhonglian Cao;Yonghui Wang;Jun Xu;Wei Fu
8 Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic 期刊论文 Huoming Huang;Wenli Wang;Xuejun Xu;Chen Zhu;Yujun Wang;Jinggen Liu;Wei Li;Wei Fu
9 一种1,2,3,4-四氢喹啉磺酰胺类化合物及其应用 专利 付伟;孙囡囡
10 Discovery of Novel N-sulfonamide-tetrahydroisoquinolines as Potent Retinoic Acid Receptor-Related Orphan Receptor γt Agonists 期刊论文 Xiaojun Ma;Nannan Sun;Xinwei Li;Wei Fu
11 3-(二甲氨基甲基)环己-4-醇衍生物及其制备方法和药物用途 专利 付伟;黄火明
12 Molecular dynamics simulations on RORγt: insights into its functional agonism and inverse agonism 期刊论文 Congming Yuan;Haihong Chen;Nannan Sun;Xiaojun Ma;Jun Xu;Wei Fu
13 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途 专利 付伟;黄火明
14 6-氨基甲基哌啶类衍生物及其制备方法和药物用途 专利 付伟;沈庆;李炜;刘景根;徐学军
15 Discovery of Novel Indolealkylpiperazine Derivatives as Potent 5-HT1A Receptor Agonists for The Potential Future Treatment of Depression 期刊论文 Chen Zhu;Xinwei Li;Weiqing Peng;Wei Fu
16 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途 专利 付伟;黄火明
17 3-(二甲氨基甲基)哌啶-4-醇衍生物制备方法和药物用途 专利 付伟;黄火明
查看更多信息请先登录或注册

相关项目

趋势报告

经验分享