E3泛素连接酶PARK2通过单泛素化修饰RAD50促进同源重组修复的分子机制及功能研究

81903069
2019
H1814.肿瘤化学药物治疗
李瑜
青年科学基金项目
助理研究员
北京大学
21万元
PARK2;DNA双链断裂;同源重组修复;乳腺癌;PARP抑制剂
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions 期刊论文 Hu Kaishun;Li Yu;Wu Wenjing;Xie Limin;Yan Haiyan;Cai Yuexin;Chen Dong;Jiang Qiongchao;Lin Lehang;Chen Zhen;Liao Jian-You;Zhang Yin;Koeffler H. Phillip;Yin Dong;Song Erwei
2 A Pan-Cancer Analysis of the Oncogenic Role of Nuclear Transport Factor 2 in Human Cancers 期刊论文 Li Yu;Huang Yongsheng;Ren Shuwei;Xiao Xing;Cao Haotian;He Juan
3 The relationships of CD8+ T cell subsets in RA patients with disease activity and clinical parameters 期刊论文 Juan He;Yu Li;Jian Chen;Qi Wu;Hongying Shan;Xiaocheng Wang;Miaomiao Zhang;Liping Nie;Qingwen Wang
4 Integrative bioinformatics analysis demonstrates the prognostic value of chromatin accessibility biomarkers in clear cell renal cell carcinoma 期刊论文 Meng Meng;Lan Tianjun;Tian Duanqing;Qin Zeman;Li Yu;Li Jinsong;Cao Haotian
5 PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2 期刊论文 Chen Hengxing;Li Yun;Li Yu;Chen Zhen;Xie Limin;Li Wenjia;Zhu Yuanxin;Xue Hong;Koeffler H. Phillip;Wu Wenjing;Hu Kaishun;Yin Dong
6 RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT 期刊论文 Chen Zhen;Wu Wenjing;Huang Yongsheng;Xie Limin;Li Yu;Chen Hengxing;Li Wenjia;Yin Dong;Hu Kaishun
7 Transcription factor NFYA promotes G1/S cell cycle transition and cell proliferation by transactivating cyclin D1 and CDK4 in clear cell renal cell carcinoma 期刊论文 Li Yu;Xiao Xing;Chen Hengxing;Chen Zhen;Hu Kaishun;Yin Dong
8 An optimized Agrobacterium tumefaciens-mediated transformation system for random insertional mutagenesis in Fonsecaea monophora 期刊论文 Xiao Xing;Li Yu;Qin JingLin;He Ya;Cai Wenying;Chen Zhiwen;Xi Liyan;Zhang Junmin
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