CFTR与血管紧张素Ⅱ 1型受体结合调控高血压血管重构及药物影响
81773722
2017
H3502.心脑血管药物药理
王冠蕾
面上项目
教授
中山大学
60万元
CFTR;血管重构;氯沙坦;高血压;血管紧张素I型受体
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | CFTR 基因在制备预警或诊断血栓性疾病药物中的应用 | 专利 | 王冠蕾 |
| 2 | LNK deficiency decreases obesity-induced insulin resistance by regulating GLUT4 through the PI3K-Akt-AS160 pathway in adipose tissue | 期刊论文 | Zhong Xiaozhu;Ke Chuanfeng;Cai Zhaoxi;Wu Hao;Ye Yang;Liang Xiaolin;Yu Liqun;Jiang Sushi;Shen Jun;Wang Laiyou;Xie Meiqing;Wang Guanlei;Zhao Xiaomiao |
| 3 | CFTR通过调控二磷酸腺苷受体P2Y12影响血小板活化 | 期刊论文 | 李俊;杨涵滟;韩慧;李梅;王冠蕾 |
| 4 | 一种模拟天然血管的新型人造血管的制备和应用 | 专利 | 王冠蕾 |
| 5 | Clcn3 deficiency ameliorates high-fat diet-induced obesity and adipose tissue macrophage inflammation in mice | 期刊论文 | Ma Mingming;Jin Chenchen;Huang Xuelian;Sun Lu;Zhou Hui;Wen Xuejun;Huang Xiongqing;Du Jieyi;Sun Hongshuo;Ren Zhuxiao;Liu Jie;Guan Yongyuan;Zhao Xiaomiao;Wang Guanlei |
| 6 | SGK1 mediates the hypotonic protective effect against H2O2-induced apoptosis of rat basilar artery smooth muscle cells by inhibiting the FOXO3a/Bim signaling pathway | 期刊论文 | Chen Bao-yi;Huang Cheng-cui;Lv Xiao-fei;Zheng Hua-qing;Zhang Ya-juan;Sun Lu;Wang Guan-lei;Ma Ming-ming;Guan Yong-yuan |
| 7 | Marine Compound Xyloketal B as a Potential Drug Development Target for Neuroprotection | 期刊论文 | Gong Haifan;Luo Zhengwei;Chen Wenliang;Feng Zhong Ping;Wang Guan Lei;Sun Hong Shuo |
| 8 | CFTR对前脂肪细胞增殖和分化的影响 | 期刊论文 | 晋晨晨;杜洁仪;黄雪莲;王冠蕾 |
| 9 | Smooth muscle-specific TMEM16A expression protects against angiotensin II-induced cerebrovascular remodeling via suppressing extracellular matrix deposition | 期刊论文 | Zeng Xue-Lin;Sun Lu;Zheng Hua-Qing;Wang Guan-Lei;Du Yan-Hua;Lv Xiao-Fei;Ma Ming-Ming;Guan Yong-Yuan |
| 10 | Decreased platelet CFTR enhances arterial thrombosis via increasing intracellular Cl- concentration and activation of the SGK1-dependent signaling pathway | 期刊论文 | Yang Hanyan;Zhang Chao;Hu Liang;Liu Chang;Pan Ni;Li Mei;Han Hui;Zhou Yi;Li Jie;Zhao Liyan;Liu Yaosheng;Luo Bingzheng;Huang xiongqing;Lv Xiaofei;Li Zicheng;Li Jun;Li Zhihong;Wang Ruomei;Wang Li;Guan Yongyuan;Liu Chanzhao;Zhang Bin;Wang Guanlei |
| 11 | Transmembrane member 16A participates in hydrogen peroxide-induced apoptosis by facilitating mitochondria-dependent pathway in vascular smooth muscle cells | 期刊论文 | Zeng Jia-Wei;Chen Bao-Yi;Lv Xiao-Fei;Sun Lu;Zeng Xue-Lin;Zheng Hua-Qing;Du Yan-Hua;Wang Guan-Lei;Ma Ming-Ming;Guan Yong-Yuan;Zeng Jia-Wei;Zeng Xue-Lin |
| 12 | 化合物Isaridin E或其药用盐在制备抗血栓药物中的应用 | 专利 | 王冠蕾 |
| 13 | CFTR deficiency aggravates Ang II induced vasoconstriction and hypertension by regulating Ca2+ influx and RhoA/Rock pathway in VSMCs | 期刊论文 | Zhao Liyan;Yuan Feng;Pan Ni;Yu Yun;Yang Hanyan;Liu Yaosheng;Wang Ruomei;Zhang Bin;Wang Guanlei |
| 14 | Antiplatelet and Antithrombotic Effects of Isaridin E Isolated from the Marine-Derived Fungus via Downregulating the PI3K/Akt Signaling Pathway | 期刊论文 | Pan Ni;Li Zicheng;Li Zhihong;Chen Senhua;Jiang Minghua;Yang Hanyan;Liu Yaosheng;Hu Rui;Zeng Yuwei;Dai Lehui;Liu Lan;Wang Guanlei |
| 15 | 第五届中国创新挑战赛(广东·广州赛区)现场赛创新奖-新型3D打印血管在血管移植和高通量药物筛选的应用研发 | 奖励 | 王冠蕾 |
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