血管平滑肌细胞LRRC8A Cl-通道的生物学特性与功能及与ClC-3 Cl-通道的关系和药物干预的研究

81773721
2017
H3502.心脑血管药物药理
关永源
面上项目
教授
中山大学
48万元
容积调节Cl-;辛伐他汀;通道;脑血管重构;ClC-3;LRRC8A
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 LRRC8A is essential for volume-regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension 期刊论文 Li Xiangyu;Lv Xiaofei;Huang Chengcui;Sun Lu;Ma Mingming;Liu Canzhao;Guan Yongyuan
2 SGK1 mediates hypotonic challenge-induced proliferation in basilar artery smooth muscle cells via promoting CREB signaling pathway 期刊论文 Chen Bao-Yi;Wang Su-Rong;Lu Feng-Ting;Lv Xiao-Fei;Chen Yuan;Ma Ming-Ming;Guan Yong-Yuan
3 SGK1 mediates the hypotonic protective effect against H2O2-induced apoptosis of rat basilar artery smooth muscle cells by inhibiting the FOXO3a/Bim signaling pathway 期刊论文 Chen Bao-yi;Huang Cheng-cui;Lv Xiao-fei;Zheng Hua-qing;Zhang Ya-juan;Sun Lu;Wang Guan-lei;Ma Ming-ming;Guan Yong-yuan
4 Transmembrane member 16A participates in hydrogen peroxide-induced apoptosis by facilitating mitochondria-dependent pathway in vascular smooth muscle cells 期刊论文 Zeng Jia Wei;Chen Bao Yi;Lv Xiao Fei;Sun Lu;Zeng Xue Lin;Zheng Hua Qing;Du Yan Hua;Wang Guan Lei;Ma Ming Ming;Guan Yong Yuan
5 TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner 期刊论文 Zheng Hua-Qing;Li Xiao-Long;Zeng Xin;Huang Cheng-Cui;Ma Mingming;Lv Xiao-Fei;Zhang Ya-Juan;Sun Lu;Wang Guan-Lei;Du Yan-Hua;Guan Yong-Yuan
6 Smooth muscle-specific TMEM16A expression protects against angiotensin II-induced cerebrovascular remodeling via suppressing extracellular matrix deposition. 期刊论文 Zeng Xue Lin;Sun Lu;Zheng Hua Qing;Wang Guan Lei;Du Yan Hua;Lv Xiao Fei;Ma Ming Ming;Guan Yong Yuan
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