BRD7通过调控染色质重塑促进转录激活区域DNA双链断裂同源重组修复的分子机制及功能研究
81872140
2018
H1804.肿瘤遗传与进化
尹东
面上项目
研究员
中山大学
62万元
BRD7;PARP1抑制剂;转录抑制;同源重组修复;染色质重塑
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT | 期刊论文 | Zhen Chen;Wenjing Wu;Yongsheng Huang;Limin Xie;Yu Li;Hengxing Chen;Wenjia Li;Dong Yin;Kaishun Hu |
| 2 | Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents | 期刊论文 | Hu Kaishun;Wu Wenjing;Li Yu;Lin Lehang;Chen Dong;Yan Haiyan;Xiao Xing;Chen Hengxing;Chen Zhen;Zhang Yin;Xu Shuangbing;Guo Yabin;Koeffler H Phillip;Song Erwei;Yin Dong |
| 3 | CIRDES: an efficient genome-wide method for in vivo RNA-RNA interactome analysis. | 期刊论文 | Li Yao-Ting;Zhou Nan;Deng Wei-Xi;Zeng Xue-Zhen;Wang Xiao-Juan;Peng Jing-Wen;Yang Bing;Wang Yan-Jie;Liao Jian-You;Yin Dong |
| 4 | PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2 | 期刊论文 | Chen Hengxing;Li Yun;Li Yu;Chen Zhen;Xie Limin;Li Wenjia;Zhu Yuanxin;Xue Hong;Koeffler H. Phillip;Wu Wenjing;Hu Kaishun;Yin Dong |
| 5 | ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions | 期刊论文 | Hu Kaishun;Li Yu;Wu Wenjing;Xie Limin;Yan Haiyan;Cai Yuexin;Chen Dong;Jiang Qiongchao;Lin Lehang;Chen Zhen;Liao Jian-You;Zhang Yin;Koeffler H. Phillip;Yin Dong;Song Erwei |
| 6 | LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network | 期刊论文 | Yin Zhang;Yong-Xin Huang;Dan-Lan Wang;Bing Yang;Hai-Yan Yan;Le-Hang Lin;Yun Li;Jie Chen;Li-Min Xie;Yong-Sheng Huang;Jian-You Liao;Kai-Shun Hu;Jie-Hua He;Phei Er Saw;Xiaoding Xu;Dong Yin |
| 7 | RNA-binding protein MEX3A controls G1/S transition via regulating the RB/E2F pathway in clear cell renal cell carcinoma | 期刊论文 | Yuntan Qiu;Meng Meng;Chuanzhen Cao;Jingyuan Zhang;Xu Cheng;Yongxin Huang;Haotian Cao;Yun Li;Duanqing Tian;Yongsheng Huang;Li Peng;Kaishun Hu;Yin Zhang;Jianyou Liao;Jiehua He;Xiaochun Wang;Daning Lu;Lehang Lin;Xingang Bi;Dong Yin |
| 8 | EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs). | 期刊论文 | Liao Jian-You;Yang Bing;Zhang Yu-Chan;Wang Xiao-Juan;Ye Yushan;Peng Jing-Wen;Yang Zhi-Zhi;He Jie-Hua;Zhang Yin;Hu KaiShun;Lin De-Chen;Yin Dong |
| 9 | Transcription factor NFYA promotes G1/S cell cycle transition and cell proliferation by transactivating cyclin D1 and CDK4 in clear cell renal cell carcinoma | 期刊论文 | Li Yu;Xiao Xing;Chen Hengxing;Chen Zhen;Hu Kaishun;Yin Dong |
| 10 | Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma | 期刊论文 | Huang Yongsheng;Yang Qian;Zheng Yueyuan;Lin Lehang;Xu Xin;Xu Xiu-E;Silva Tiago C.;Hazawa Masaharu;Peng Li;Cao Haotian;Ding Yanbing;Lu Daning;Berman Benjamin P.;Xu Li-Yan;Li En-Min;Yin Dong |
| 11 | 一种鉴别人源细胞和小鼠源细胞的方法 | 专利 | 尹东;王永强;张寅 |
| 12 | Overexpression of lncRNAs with endogenous lengths and functions using a lncRNA delivery system based on transposon | 期刊论文 | Zhang Yin;Huang Yong-Xin;Jin Xin;Chen Jie;Peng Li;Wang Dan-Lan;Li Yun;Yao Xin-Yi;Liao Jian-You;He Jie-Hua;Hu KaiShun;Lu Daning;Guo Yabin;Yin Dong |
| 13 | CHFR-mediated degradation of RNF126 confers sensitivity to PARP inhibitors in triple-negative breast cancer cells | 期刊论文 | Wu Wenjing;Zhao Jianli;Xiao Jianhong;Wu Weijun;Xie Limin;Xie Xiaojuan;Yang Chaoye;Yin Dong;Hu Kaishun |
| 14 | Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1 | 期刊论文 | Lin Lehang;Huang Moli;Shi Xianping;Mayakonda Anand;Hu Kaishun;Jiang Yan Yi;Guo Xiao;Chen Li;Pang Brendan;Doan Ngan;Said Jonathan W;Xie Jianjun;Gery Sigal;Cheng Xu;Lin Zhaoyu;Li Jinsong;Berman Benjamin P;Yin Dong;Lin De Chen;Koeffler H Phillip |
| 15 | Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia | 期刊论文 | Wang Yan-Jie;Yang Bing;Lai Qiao;Shi Jun-Fang;Peng Jiang-Yun;Zhang Yin;Hu Kai-Shun;Li Ya-Qing;Peng Jing-Wen;Yang Zhi-Zhi;Li Yao-Ting;Pan Yue;Koeffler H. Phillip;Liao Jian-You;Yin Dong |
| 16 | 一种用于高效稳定过表达长链非编码RNA的克隆载体及其应用; | 专利 | 尹东;张寅;黄泳欣;陈捷;汪单兰;郭雅彬 |
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