干细胞源性神经网络支架移植修复脊髓受损伤神经网络的机制研究
81330028
2013
H0910.神经损伤、修复与再生
曾园山
重点项目
教授
中山大学
280万元
NSC源性神经网络;神经营养素-3;脊髓损伤修复;LINGO-1拮抗剂;神经营养素-3受体/TrkC
2014-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 一种基质化去细胞神经支架 | 专利 | 曾园山;李戈;孙佳慧 |
| 2 | Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats | 期刊论文 | Zhang Yu-Ting;Jin Hui;Wang Jun-Hua;Wen Lan-Yu;Yang Yang;Ruan Jing-Wen;Zhang Shu-Xin;Ling Eng-Ang;Ding Ying;Zeng Yuan-Shan |
| 3 | Recovery of paralyzed limb motor function in canine with complete spinal cord injury following implantation of MSC-derived neural network tissue | 期刊论文 | Guohui Wu;Huijuan Shi;Mingtian Che;Meng-Yao Huang;Qingshuai Wei;Bo Feng;Yuanhuan Ma;Laijian Wang;Bin Jiang;Yaqiong Wang;Inbo Han;Eng-Ang Ling;Xiang Zeng;Yuanshan Zeng |
| 4 | Perineurium-like sheath derived from long-term surviving mesenchymal stem cells confers nerve protection to the injured spinal cord | 期刊论文 | Yuan-Huan Ma;Xiang Zeng;Xue-Cheng Qiu;Qing-Shuai Wei;Ming-Tian Che;Ying Ding;Zhou Liu;Guo-Hui Wu;Jia-Hui Sun;Mao Pang;Li-Min Rong;Bin Liu;Zaid Aljuboori;Inbo Han;Eng-Ang Ling;Yuan-Shan Zeng |
| 5 | Neurotrophin-3 released from implant of tissue-engineered fibroin scaffolds inhibits inflammation, enhances nerve fiber regeneration and improves motor function in canine spinal cord injury | 期刊论文 | Ge Li;Ming-Tian Che;Xiang Zeng;Xue-Cheng Qiu;Bo Feng;Bi-Qin Lai;Hui-Yong Shen;Eng-Ang Ling;Yuan-Shan Zeng |
| 6 | A modular assembly of spinal cord-like tissue endows targeted tissue repair in the transected spinal cord | 期刊论文 | Biqin Lai;Bo Feng;Mingtian Che;Laijian Wang;Song Cai;Mengyao Huang;Huaiyu Gu;Bin Jiang;Eng-Ang Ling;Meng Li;Xiang Zeng;Yuanshan Zeng |
| 7 | Graft of the NT-3 persistent delivery gelatin sponge scaffold promotes axon regeneration, attenuates inflammation, and induces cell migration in rat and canine with spinal cord injury | 期刊论文 | Li Ge;Che Ming-Tian;Zhang Ke;Qin Li-Na;Zhang Yu-Ting;Chen Rui-Qiang;Rong Li-Min;Liu Shu;Ding Ying;Shen Hui-Yong;Long Si-Mei;Wu Jin-Lang;Ling Eng-Ang;Zeng Yuan-Shan |
| 8 | Cell Transplantation and Neuroengineering Approach for Spinal Cord Injury Treatment: A Summary of Current Laboratory Findings and Review of Literature | 期刊论文 | Lin Xin-Yi;Lai Bi-Qin;Zeng Xiang;Che Ming-Tian;Zeng Yuan-Shan;Ling Eng-Ang;Wu Wutian;Wu Wutian;Wu Wutian;Zeng Yuan-Shan;Zeng Yuan-Shan;Zeng Yuan-Shan;Zeng Yuan-Shan;Zeng YS |
| 9 | Peripheral nerve-derived matrix hydrogel promotes remyelination and inhibits synapse formation | 期刊论文 | Jianlong Zou;Sheng Liu;Jiahui Sun;Weihong Yang;Yiwei Xu;Zilong Rao;Bin Jiang;Qingtang Zhu;Xiaolin Liu;Jinlang Wu;Calvin Chang;Haiquan Mao;Eng-Ang Ling;Daping Quan;Yuanshan Zeng |
| 10 | 督脉经穴电针通过NT-3介导移植的成体干细胞修复脊髓损伤的研究 | 奖励 | 曾园山;丁英;阮经文;刘洲;李文杰;张可;陈雅云;曾湘;李晓滨;李淑敏 |
| 11 | 一种具有趋化功能的生物活性支架的制备和应用 | 专利 | 曾园山;李戈 |
| 12 | Combination of electroacupuncture and grafted mesenchymal stem cells overexpressing TrkC improves remyelination and function in demyelinated spinal cord of rats | 期刊论文 | Ying Ding;Rongyi Zhang;Bing He;Zhou Liu;Ke Zhang;Jingwen Ruan;Eng-Ang Ling;Jinlang Wu;Yuanshan Zeng |
| 13 | Effects of electroacupuncture and the retinoid X receptor (RXR) signalling pathway on oligodendrocyte differentiation in the demyelinated spinal cord of rats | 期刊论文 | Yang Xiao-Hua;Ding Ying;Li Wen;Zhang Rong-Yi;Wu Jin-Lang;Ling Eng-Ang;Wu Wutian;Zeng Yuan-Shan |
| 14 | Autocrine fibronectin from differentiating mesenchymal stem cells induces the neurite elongation in vitro and promotes nerve fiber regeneration in transected spinal cord injury | 期刊论文 | Zeng Xiang;Ma Yuan-huan;Qiu Xue-cheng;Zeng Yuan-shan;Ma Yuan-huan;Chen Yuan-feng;Zeng Yuan-shan;Wu Jin-lang;Ling Eng-Ang;Zeng Yuan-shan;Zeng Yuan-shan;Zeng Yuan-shan;Zeng YS |
| 15 | 一种具有趋化功能的生物活性支架的制备和应用 | 专利 | 曾园山;李戈 |
| 16 | Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord | 期刊论文 | Lai Bi-Qin;Che Ming-Tian;Zeng Xiang;Ma Yuan-Huan;Feng Bo;Qiu Xue-Chen;Zeng Yuan-Shan;Du Bao-Ling;Zhang Ke;Zeng Yuan-Shan;Shen Hui-Yong;Zeng Yuan-Shan;Zeng Yuan-Shan;Zeng Yuan-Shan;Liu Shu;Shen Hui-Yong;Wu Jin-Lang;Ling Eng-Ang;Zeng YS |
| 17 | Donor mesenchymal stem cell-derived neural-like cells transdifferentiate into myelin-forming cells and promote axon regeneration in rat spinal cord transection | 期刊论文 | Qiu Xue-Cheng;Jin Hui;Zhang Rong-Yi;Ding Ying;Zeng Xiang;Lai Bi-Qin;Ling Eng-Ang;Wu Jin-Lang;Zeng Yuan-Shan |
| 18 | Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection | 期刊论文 | Xiang Zeng;Xuecheng Qiu;Yuanhuan Ma;Jingjing Duan;Yuanfeng Chen;Huanyu Gu;Junmei Wang;Eng-Ang Ling;Jinlang Wu;Wutian Wu;Yuanshan Zeng |
| 19 | Cholera Toxin B Subunit Shows Transneuronal Tracing after Injection in an Injured Sciatic Nerve | 期刊论文 | Lai Bi-Qin;Qiu Xue-Chen;Jin Hui;Li Ge;Zeng Yuan-Shan;Zhang Ke;Zhang Rong-Yi;Zeng Yuan-Shan;Shen Hui-Yong;Zeng Yuan-Shan;Zeng Yuan-Shan;Shen Hui-Yong;Wu Jin-Lang;Ling Eng-Ang;Zeng Yuan-Shan;Zeng YS |
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