基于mRNA 5'UTR G-四链体调控α-分泌酶的抗阿尔茨海默症先导化合物的发现与分子机制研究

81273433
2012
H3407.药物设计与药物信息
黄志纾
面上项目
教授
中山大学
80万元
mRNA;5'UTR;G-四链体;先导化合物;Aβ生成抑制;新机制;α-分泌酶
2013-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment. 期刊论文 Li, Ding|Gu, Lian-Quan|Ye, Ji-Ming|Huang, Zhi-Shu|
2 Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease 期刊论文 Shi-Liang Huang|Lian-Quan Gu|Zhi-Shu Huang|Ding Li|
3 Syntheses and Evaluation of Asymmetric Curcumin Analogues as Potential Multifunctional Agents for the Treatment of Alzheimer's Disease 期刊论文 Ou, Tian-Miao|Huang, Shi-Liang|Gu, Lian-Quan|Huang, Zhi-Shu|
4 Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5 ' Untranslated Region (UTR) of Its mRNA 期刊论文 Tan, Jia-Heng|Li, Ding|Gu, Lian-Quan|Huang, Zhi-Shu|
5 Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease 期刊论文 Jia-Heng Tan|Ding Li|Lian-Quan Gu|Zhi-Shu Huang|
6 Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease 期刊论文 Shi-Liang Huang|Ding Li|Lian-Quan Gu|Zhi-Shu Huang|
7 Rutaecarpine Analogues Reduce Lipid Accumulation in Adipocytes via Inhibiting Adipogenesis/Lipogenesis with AMPK Activation and UPR Suppression 期刊论文 Liu, Pei-Qing|Gu, Lian-Quan|Ye, Ji-Ming|Huang, Zhi-Shu|
8 Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase 期刊论文 Huang, Shi-Liang|Gu, Lian-Quan|Xu, Jun|Huang, Zhi-Shu|
9 Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes 期刊论文 Huang, Shi-Liang|Gu, Lian-Quan|Ye, Ji-Ming|Huang, Zhi-Shu|
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