Galectin-9/CD44介导的滋养细胞-蜕膜巨噬细胞异常对话诱导胎盘血管重塑不良致子痫前期的分子机制

31970859
2019
C0807.生殖免疫与移植免疫
杜美蓉
面上项目
研究员
复旦大学
59万元
滋养层细胞;蜕膜巨噬细胞;胎盘血管重塑;子痫前期;母-胎免疫
2020-01-01到2023-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 TORC2/3-mediated DUSP1 upregulation is essential for human decidualization 期刊论文 Chunfang Xu;Weijie Zhao;Xixi Huang;Zhuxuan Jiang;Lu Liu;Liyuan Cui;Xinyi Li;Dajin Li;Meirong Du
2 cAMP/PKA signaling promotes AKT deactivation by reducing CIP2A expression, thereby facilitating decidualization 期刊论文 Weijie Zhao;Chunfang Xu;Lijin Peng;Lin Ma;Meirong Du
3 Melatonin regulates proliferation and apoptosis of endometrial stromal cells via MT1 期刊论文 Liyuan Cui;Feng Xu;Zhuxuan Jiang;Songcun Wang;Xinyi Li;Yan Ding;Ying Zhang;Meirong Du
4 Mesenchymal stem cells enhance Treg immunosuppressive function at the fetal-maternal interface 期刊论文 Zhang Di;Lin Yikong;Li Yunyun;Zhao Dong;Du Meirong
5 Tissue‐resident CD8 + T memory cells with unique properties are present in human decidua during early pregnancy 期刊论文 Xixi Huang;Lu Liu;Chunfang Xu;Xiandong Peng;Dajin Li;Li Wang;Meirong Du
6 Galectin-9 regulates HTR8/SVneo function via JNK signaling 期刊论文 Mengdie Li;Xiandong Peng;Jinfeng Qian;Fengrun Sun;Chunqin Chen;Songcun Wang;Jianping Zhang;Meirong Du
7 Tim-3 Coordinates Macrophage-Trophoblast Crosstalk via Angiogenic Growth Factors to Promote Pregnancy Maintenance 期刊论文 Liyuan Cui;Fengrun Sun;Yuanyuan Xu;Mengdie Li;Lanting Chen;Chunqin Chen;Jinfeng Qian;Dajin Li;Meirong Du;Songcun Wang
8 Involvement of the Tim-3 Pathway in the Pathogenesis of Pre-Eclampsia 期刊论文 Wang Songcun;Chen Chunqin;Sun Fengrun;Li Mengdie;Du Meirong;Li Xiaotian;Zhang Ying
9 Decidual CD8+T cells exhibit both residency and tolerance signatures modulated by decidual stromal cells 期刊论文 Lu Liu;Xixi Huang;Chunfang Xu;Chunqin Chen;Weijie Zhao;Dajin Li;Liping Li;Li Wang;Meirong Du
10 Endometrial organoids and trophoblast organoids: Novel models for investigation of maternal-fetal interactions 期刊论文 Lijin Peng;Tingxuan Yin;Weijie Zhao;Chunfang Xu;Meirong Du
11 Downregulation of CRHBP is associated with trophoblast invasion inhibition in recurrent pregnancy loss. 期刊论文 Sun FR;Cui LY;Qian JF;Du MR;Wang SC
12 Dysfunction of CCR1+ decidual macrophages is a potential risk factor in the occurrence of unexplained recurrent pregnancy loss 期刊论文 Yifei Sang;Yanhong Li;Ling Xu;Jiajia Chen;Dajin Li;Meirong Du
13 SCM-198 ameliorates endometrial inflammation via suppressing the LPS-JNK- cJUN/cFOS-TLR4-NF-kappa B pathway 期刊论文 Lin Yikong;Li Yunyun;Li Xinyi;Liu Xinhua;Wang Xiaolin;Yu Min;Zhu Yizhun;Du Meirong
14 Circadian rhythm‐associated Rev‐erbα modulates polarization of decidual macrophage via the PI3K/Akt signaling pathway 期刊论文 Liyuan Cui;Xueling Jin;Feng Xu;Songcun Wang;Lu Liu;Xinyi Li;Haiyan Lin;Meirong Du
15 Delayed Antiviral Immune Responses in Severe Acute Respiratory Syndrome Coronavirus Infected Pregnant Mice 期刊论文 Guohua Zhu;Shujuan Du;Yuyan Wang;Xixi Huang;Gaowei Hu;Xin Lu;Dajin Li;Yizhun Zhu;Di Qu;Qiliang Cai;Lu Liu;Meirong Du
16 Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss 期刊论文 Liyuan Cui;Feng Xu;Songcun Wang;Xinyi Li;Haiyan Lin;Yan Ding;Meirong Du
17 Decidualization-derived cAMP regulates phenotypical and functional conversion of decidual NK cells from CD56dimCD16- NK cells 期刊论文 Xueling Jin;Liyuan Cui;Weijie Zhao;Xinyi Li;Lu Liu;Yanhong Li;Qiang Fu;Dajin Li;Min Yu;Meirong Du
18 The risk of intrauterine exposure to SARS-CoV-2 in female COVID-19 patients: a comprehensive Review. 期刊论文 Guo-Hua Zhu;Lu Liu;Xi-Xi Huang;Da-Jin Li;Yi-Zhun Zhu;Xin Lu;Mei-Rong Du
19 RhoB Promotes Endometrial Stromal Cells Decidualization Via Semaphorin3A/plexinA4 Signaling in Early Pregnancy 期刊论文 Ling Xu;Yan Hong Li;Wei Jie Zhao;Yi Fei Sang;Jia Jia Chen;Da-Jin Li;Meirong Du
20 Crosstalk Between Trophoblasts and Decidual Immune Cells: The Cornerstone of Maternal-Fetal Immunotolerance 期刊论文 Ling Xu;Yanhong Li;Yifei Sang;Da-Jin Li;Meirong Du
21 Melatonin-MT1 signal is essential for endometrial decidualization 期刊论文 Cui L;Xu F;Wang S;Jiang Z;Liu L;Ding Y;Sun X;Du M
22 Decidualization-derived cAMP promotes decidual NK cells to be angiogenic phenotype. 期刊论文 Xueling Jin;Lie Mao;Weijie Zhao;Lu Liu;Yanhong Li;Dajin Li;Ying Zhang;Meirong Du
23 WNT16 from decidual stromal cells regulates HTR8/SVneo trophoblastic cell function via AKT/beta-catenin pathway 期刊论文 Xinyi Li;Jiaxin Shi;Weijie Zhao;Xixi Huang;Liyuan Cui;Lu Liu;Xueling Jin;Djin Li;Xuan Zhang;Meirong Du
24 Paradoxical expression of NRP1 in decidual stromal and immune cells reveals a novel inflammation balancing mechanism during early pregnancy 期刊论文 Jiajia Chen;Yanhong Li;Ling Xu;Yifei Sang;Dajin Li;Meirong Du
25 A Galectin-9-Driven CD11chigh Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia. 期刊论文 Li Yanhong;Sang Yifei;Chang Yunjian;Xu CHunfang;Lin Yikong;Zhang Yao;Philip CN Chiu;William S.B. Yeung;Zhou Haisheng;Dong Ningzheng;Xu Ling;Chen Jiajia;Zhao Weijie;Liu Lu;Yu Di;Zang Xingxing;Ye Jiangfeng;YangoJinying;Wu Qinyu;Li Dajin;Wu Ligang;Du Meirong
26 Mifepristone(RU486)Inducing Abortion in a Mouse Model by Regulating Innate and Adaptive Immune Responses 期刊论文 Li Mengdie;Sang Yifei;Tang Yunhui;Xu Ling;Xu Chunfang;Li Dajin;Li Yanhong;Zhang Jianping;Du Meirong
27 Pigment epithelium-derived factor (PEDF), a novel decidual natural killer cells-derived factor, protects decidual stromal cells via anti-inflammation and anti-apoptosis in early pregnancy. 期刊论文 Zheng J;Li YH;Sang YF;Xu L;Li DJ;Du MR
28 Decidual Stromal Cell Ferroptosis Associated with Abnormal Iron Metabolism Is Implicated in the Pathogenesis of Recurrent Pregnancy Loss 期刊论文 Sun FR;Cui LY;Qian JF;Li MD;Chen LT;Chen CQ;Li DJ;Wang SC;Du MR
29 SCM-198 Alleviates Endometriosis by Suppressing Estrogen-ERα mediated Differentiation and Function of CD4+CD25+ Regulatory T Cells 期刊论文 Yun-yun Li;Yi-kong Lin;Yue Li;Xin-hua Liu;Da-jin Li;Xiao-lin Wang;Li Wang;Yi-zhun Zhu;Min Yu;Mei-rong Du
30 SCM-198 Prevents Endometriosis by Reversing Low Autophagy of Endometrial Stromal Cell via Balancing ERα and PR Signals 期刊论文 Yi-Kong Lin;Yun-Yun Li;Yue Li;Da-Jin Li;Xiao-Lin Wang;Li Wang;Min Yu;Yi-Zhun Zhu;Jia-Jing Cheng;Mei-Rong Du
31 Obesity Challenge Drives Distinct Maternal Immune Response Changes in Normal Pregnant and Abortion-Prone Mouse Models 期刊论文 Yanhong Li;Jiajia Chen;Yikong Lin;Ling Xu;Yifei Sang;Dajin Li;Meirong Du
32 Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization 期刊论文 Liu Yanqin;Du Meirong;Lin Hai-Yan
33 Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis 期刊论文 Liyuan Cui;Feng Xu;Chunfang Xu;Yan Ding;Songcun Wang;Meirong Du
34 Decidual NR2F2-Expressing CD4+ T Cells Promote TH2 Transcriptional Program During Early Pregnancy 期刊论文 Yikong Lin;Di Zhang;Yangyang Li;Yunyun Li;Bin Li;Meirong Du
35 Norepinephrine exposure restrains endometrial decidualization during early pregnancy 期刊论文 Jiju Wang;Yunhui Tang;Songcun Wang;Liyuan Cui;Da-Jin Li;Meirong Du
36 The unique expression pattern of human leukocyte antigen in trophoblasts potentially explains the key mechanism of maternal-fetal tolerance and successful pregnancy 期刊论文 Lijin Peng;Weijie Zhao;Tingxuan Yin;Chunfang Xu;Guangchuan Wang;Meirong Du
37 Decidual CXCR4 + CD56 bright NK cells as a novel NK subset in maternal–foetal immune tolerance to alleviate early pregnancy failure 期刊论文 Yu Tao;Yan‐Hong Li;Di Zhang;Ling Xu;Jia‐Jia Chen;Yi‐Fei Sang;Hai‐Lan Piao;Xue‐Ling Jing;Min Yu;Qiang Fu;Sheng‐Tao Zhou;Da‐Jin Li;Mei‐Rong Du
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