【31270869】细胞内金属锰离子转运、调控蛋白的结构基础及其作用分子机制研究国家自然基金项目

细胞内金属锰离子转运、调控蛋白的结构基础及其作用分子机制研究

项目批准号： 31270869

批准年份： 2012

学科分类： C0506.糖、脂生物化学

项目负责人：谭相石

资助类别：面上项目

负责人职称：教授

依托单位：复旦大学

资助金额： 80万元

关键词：锰超氧化物歧化酶;金属锰与疾病;锰调控蛋白;金属转运分子机制;锰转运蛋白

起止时间： 2013-01-01到2016-12-31

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序号	标题	类型	作者
1	Distinct roles of a tyrosine-associated hydrogen-bond network in fine-tuning the structure and function of heme proteins: two cases designed for myoglobin	期刊论文	Gao, Shu-Qin\|Wen, Ge-Bo\|Lin, Ying-Wu\|Tan, Xiangshi\|
2	Human soluble guanylate cyclase as a nitric oxide sensor for NO-signalling reveals a novel function of nitrite reductase	期刊论文	Xu, Qiming\|Lin, Ying-Wu\|Zhong, Fangfang\|Tan, Xiangshi\|
3	Cytochrome P450 2C8 and Drug Metabolism	期刊论文	Lv, Xiaoping\|Zhong, Fangfang\|Tan, Xiangshi\|
4	The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of A beta(1-42) with Cu ions	期刊论文	Ding, Zhichun\|Zhu, Cuiqing\|Huang, Zhong-Xian\|Tan, Xiangshi\|
5	Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMPSTING-IRF3 Mediated Innate Immune Response	期刊论文	Tan, Jason\|Rui, Yaocheng\|Li, Pingwei\|Tan, Xiangshi\|
6	Structural, spectroscopic and functional investigation into Fe-substituted MnSOD from human pathogen Clostridium difficile	期刊论文	Li, Wei\|Wang, Hongfei\|Wang, Qingli\|Tan, Xiangshi\|
7	How a novel tyrosine-heme cross-link fine-tunes the structure and functions of heme proteins: a direct comparitive study of L29H/F43Y myoglobin	期刊论文	Nie, Chang-Ming\|Wen, Ge-Bo\|Lin, Ying-Wu\|Tan, Xiangshi\|
8	Exploring the differences between mouse mA beta(1-42) and human hA beta(1-42) for Alzheimer's disease related properties and neuronal cytotoxicity	期刊论文	Wang, Dandan\|Zhu, Cuiqing\|Huang, Zhong-Xian\|Tan, Xiangshi\|
9	阿尔茨海默病相关的金属内稳态平衡调控研究	期刊论文	吕小平\|谭相石\|
10	Structural and functional investigation into acetyl-coenzyme A synthase and methyltransferase from human pathogen Clostridium difficile	期刊论文	Zhang, Sixue\|Liu, Yi\|Wang, Yu\|Tan, Xiangshi\|
11	The α and β domains of human metallothionein-3 co-operatively protect against Aβ1–42–Cu2+ cytotoxicity	期刊论文	Zhi Chun Ding\|Cui Qing Zhu\|Zhong Xian Huang\|Xiang Shi Tan\|
12	The molecular mechanism of heme loss from oxidized soluble guanylate cyclase induced by conformational change	期刊论文	Zhang, Huijuan\|Zhou, Yajun\|Huang, Zhong-Xian\|Tan, Xiangshi\|
13	A Novel Tyrosine-Heme C-O Covalent Linkage in F43Y Myoglobin: A New Post-translational Modification of Heme Proteins	期刊论文	Xiang, Yu\|Wen, Ge-Bo\|Lin, Ying-Wu\|Tan, Xiangshi\|
14	Manganese superoxide dismutase from human pathogen Clostridium difficile	期刊论文	Hongfei Wang\|Cheng Lei\|Tianlei Ying\|Xiangshi Tan*\|
15	Soluble guanylate cyclase in NO signaling transduction	期刊论文	Pan, Jie\|Zhong, Fangfang\|Tan, Xiangshi\|
16	Probing the molecular mechanism of cerium oxide nanoparticles in protecting against the neuronal cytotoxicity of A beta(1-42) with copper ions	期刊论文	Wang, Dandan\|Tan, Jason\|Zhu, Cuiqing\|Tan, Xiangshi\|
17	Probing the metal specificity mechanism of superoxide dismutase from human pathogen Clostridium difficile	期刊论文	Xu, Xin\|Huang, Zhongxian\|Li, Pingwei\|Tan, Xiangshi\|
18	锰离子转运、代谢与稳态平衡调控	期刊论文	李威\|谭相石\|
19	Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase	期刊论文	Wang, Zhen\|Tian, Yang\|Huang, Zhong-Xian\|Tan, Xiangshi\|
20	Regulating the Coordination State of a Heme Protein by a Designed Distal Hydrogen-Bonding Network	期刊论文	Li, Lianzhi\|Wen, Ge-Bo\|Lin, Ying-Wu\|Tan, Xiangshi\|
21	Probing the metal specificity mechanism of superoxide dismutase from human pathogen Clostridium difficile	期刊论文	Xu, Xin\|Huang, Zhongxian\|Li, Pingwei\|Tan, Xiangshi\|

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