【31270863】持续性乙型肝炎病毒感染调控肝癌细胞膜表面gp130的N-糖基化修饰的分子机制和功能意义研究国家自然基金项目

持续性乙型肝炎病毒感染调控肝癌细胞膜表面gp130的N-糖基化修饰的分子机制和功能意义研究

项目批准号： 31270863

批准年份： 2012

学科分类： C0506.糖、脂生物化学

项目负责人：徐洁杰

资助类别：面上项目

负责人职称：教授

依托单位：复旦大学

资助金额： 80万元

关键词：乙型肝炎病毒;白细胞介素6;内吞;糖蛋白130;N-糖基化

起止时间： 2013-01-01到2016-12-31

中英文摘要
结题摘要
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序号	标题	类型	作者
1	Prognostic Significance of p21-activated Kinase 6 Expression in Patients with Clear Cell Renal Cell Carcinoma	期刊论文	Zhang, Weijuan\|Zhu, Yu\|Xu, Jiejie\|Gu, Jianxin\|
2	High CXC chemokine receptor 4 expression is an adverse prognostic factor in patients with clear-cell renal cell carcinoma	期刊论文	Liu, H.\|Chen, L. C\|Xu, J.\|Lin, Z.\|
3	Interleukin-11 receptor predicts post-operative clinical outcome in patients with early-stage clear-cell renal cell carcinoma	期刊论文	Zhang, Weijuan\|Zhu, Yu\|Xu, Jiejie\|Gu, Jianxin\|
4	Prognostic Value of SETD2 Expression in Patients with Metastatic Renal Cell Carcinoma Treated with Tyrosine Kinase Inhibitors	期刊论文	Xiong, Ying\|Long, Qilai\|Xu, Jiejie\|Guo, Jianming\|
5	Granulocyte macrophage colony-stimulating factor predicts postoperative recurrence of clear-cell renal cell carcinoma	期刊论文	Liu, Zheng\|Yang, Yuanfeng\|Lin, Zongming\|Xu, Jiejie\|
6	Podoplanin associates with adverse postoperative prognosis of patients with clear cell renal cell carcinoma	期刊论文	Xi, Wei\|Qu, Yang\|Xu, Jiejie\|Guo, Jianming\|
7	High expression of chemokine CCL2 is associated with recurrence after surgery in clear-cell renal cell carcinoma	期刊论文	Shi, Tianming\|Tan, Cheng\|Xu, Le\|Xu, Jiejie\|
8	The prognostic value of CXC-chemokine receptor 2 (CXCR2) in gastric cancer patients	期刊论文	Qin, Jing\|Xu, Jiejie\|Sun, Yihong\|Qin, Xinyu\|
9	Positive intratumoral chemokine (C-C motif) receptor 8 expression predicts high recurrence risk of post-operation clear-cell renal cell carcinoma patients	期刊论文	Zhu, Yu\|Xu, Le\|Zhang, Weijuan\|Xu, Jiejie\|
10	Prognostic significance of ubiquinol-cytochrome c reductase hinge protein expression in patients with clear cell renal cell carcinoma	期刊论文	Zhang, Wei-Juan\|Xu, Le\|Chang, Yuan\|Xu, Jie-Jie\|
11	Sorafenib suppresses growth and survival of hepatoma cells by accelerating degradation of enhancer of zeste homolog 2	期刊论文	Chen, Lin\|Wu, Qian\|Xu, Jiejie\|Gu, Jianxin\|
12	beta 1,6-N-acetylglucosaminyltransferase V predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection	期刊论文	Liu, Weisi\|Zhang, Weijuan\|An, Huimin\|Xu, Jiejie\|
13	Increased expression of alpha SMA is associated with poor prognosis in patients with gastric cancer after surgical resection	期刊论文	Qin, Jing\|Qin, Xinyu\|Xu, Jiejie\|Sun, Yihong\|
14	High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma	期刊论文	Fu, Hangcheng\|Wang, Zewei\|Liu, Haiou\|Xu, Jiejie\|
15	Expression of IL-4 and IL-13 predicts recurrence and survival in localized clear-cell renal cell carcinoma	期刊论文	Fu, Qiang\|Chen, Lian\|Lin, Zongming\|Xu, Jiejie\|
16	Prognostic value of preoperative lymphocyte to monocyte ratio in patients with nonmetastatic clear cell renal cell carcinoma	期刊论文	Liu, Zheng\|Yang, Yuanfeng\|Lin, Zongming\|Xu, Jiejie\|
17	The Presence of Vascular Mimicry Predicts High Risk of Clear Cell Renal Cell Carcinoma after Radical Nephrectomy	期刊论文	Fu, Qiang\|Yang, Yuanfeng\|Lin, Zongming\|Xu, Jiejie\|
18	Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma	期刊论文	Zhang, Weijuan\|Zhu, Yu\|Xu, Le\|Xu, Jiejie\|
19	High Level of Anaphylatoxin C5a Predicts Poor Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma	期刊论文	Long, Qilai\|Wang, Yiwei\|Xu, Jiejie\|Guo, Jianming\|
20	Notch1 Predicts Recurrence and Survival of Patients With Clear-cell Renal Cell Carcinoma After Surgical Resection	期刊论文	Xu, Le\|Chen, Lian\|Lin, Zongming\|Xu, Jiejie\|
21	p21-activated kinase 1 predicts recurrence and survival in patients with non-metastatic clear cell renal cell carcinoma	期刊论文	An, Huimin\|Liu, Weisi\|Wang, Zhong\|Xu, Jiejie\|
22	Increased expression of C-C motif ligand 2 associates with poor prognosis in patients with gastric cancer after gastrectomy	期刊论文	Qin, Jing\|Qin, Xinyu\|Xu, Jiejie\|Sun, Yihong\|
23	Increased expression of interleukin-8 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma	期刊论文	Liu, Weisi\|Fu, Qiang\|Ye, Dingwei\|Xu, Jiejie\|
24	IL-33 is associated with unfavorable postoperative survival of patients with clear-cell renal cell carcinoma	期刊论文	Fu, Hangcheng\|Zhang, Weijuan\|Yang, Yuanfeng\|Xu, Jiejie\|
25	Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma	期刊论文	Wang, Zewei\|Fu, Qiang\|Xu, Jiejie\|Ye, Dingwei\|
26	Decreased Expression of Hepatocyte Nuclear Factor 4 alpha (Hnf4 alpha)/MicroRNA-122 (miR-122) Axis in Hepatitis B Virus-associated Hepatocellular Carcinoma Enhances Potential Oncogenic GALNT10 Protein Activity	期刊论文	Yang, Liu\|Fu, Qiang\|Xu, Jie-Jie\|Gu, Jian-Xin\|
27	Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis by stabilizing Snail protein	期刊论文	Chen, Lin\|Wu, Qian\|Xu, Jiejie\|Gu, Jianxin\|
28	Clinical and prognostic implications of beta 1, 6-N-acetylglucosaminyltransferase V in patients with gastric cancer	期刊论文	Xu, Jiejie\|Gu, Jianxin\|Qin, Xinyu\|Sun, Yihong\|
29	Elevated expression of IFN-inducible CXCR3 ligands predicts poor prognosis in patients with non-metastatic clear-cell renal cell carcinoma	期刊论文	Chang, Yuan\|Xu, Le\|Zhang, Weijuan\|Xu, Jiejie\|
30	CCL2/CCR2 axis is associated with postoperative survival and recurrence of patients with non-metastatic clear-cell renal cell carcinoma	期刊论文	Fu, Hangcheng\|Zhu, Yu\|Xu, Le\|Xu, Jiejie\|
31	GALNT4 Predicts Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma	期刊论文	Zhang, Weijuan\|Zhu, Yu\|Xu, Jiejie\|Gu, Jianxin\|
32	Decreased expression of CTR2 predicts poor prognosis of patients with clear cell renal cell carcinoma	期刊论文	Bai, Qi\|Wang, Jiajun\|Xu, Jiejie\|Guo, Jianming\|
33	EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma	期刊论文	Liu, Yidong\|Liu, Weisi\|Zhang, Weijuan\|Xu, Jiejie\|
34	Notch1 activation is a poor prognostic factor in patients with gastric cancer	期刊论文	Zhang, H.\|Wang, X.\|Xu, J.\|Sun, Y.\|
35	Decreased expression of Siglec-8 associates with poor prognosis in patients with gastric cancer after surgical resection	期刊论文	Li, Ruochen\|Zhang, Weijuan\|Shen, Zhenbin\|Xu, Jiejie\|
36	Galectin-8 is associated with recurrence and survival of patients with non-metastatic gastric cancer after surgery	期刊论文	Li, He\|Shen, Zhenbin\|Qin, Jing\|Xu, Jiejie\|
37	High peritumoral Bmi-1 expression is an independent prognosticator of poor prognosis in renal cell carcinoma	期刊论文	Bai, Qi\|Wang, Jiajun\|Xu, Jiejie\|Guo, Jianming\|
38	High expression of Solute Carrier Family 1, member 5 (SLC1A5) is associated with poor prognosis in clear-cell renal cell carcinoma	期刊论文	Zhang, Weijuan\|Zhu, Yu\|Xu, Le\|Xu, Jiejie\|
39	Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells	期刊论文	An, Huimin\|Liu, Haiou\|Xu, Jiejie\|Lin, Zongming\|
40	p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-kappa B/IL-6 activation in renal cell carcinoma	期刊论文	Liu, W.\|Liu, Y.\|Lin, Z.\|Xu, J.\|
41	Increased expression of IDO associates with poor postoperative clinical outcome of patients with gastric adenocarcinoma	期刊论文	Qin, Jing\|Qin, Xinyu\|Xu, Jiejie\|Sun, Yihong\|
42	Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma	期刊论文	Xiong, Ying\|Long, Qilai\|Xu, Jiejie\|Guo, Jianming\|
43	Prognostic value of UTX expression in patients with clear cell renal cell carcinoma	期刊论文	Bai, Qi\|Xia, Yu\|Xu, Jiejie\|Guo, Jianming\|
44	Elevated Expression of N-Acetylgalactosaminyltransferase 10 Predicts Poor Survival and Early Recurrence of Patients with Clear-Cell Renal Cell Carcinoma	期刊论文	Liu, Haiou\|Zhang, Weijuan\|Le, Xu\|Xu, Jiejie\|
45	Prognostic value of stromal cell-derived factor 1 expression in patients with gastric cancer after surgical resection	期刊论文	Shen, Zhenbin\|Tang, Zhaoqing\|Xu, Jiejie\|Sun, Yihong\|
46	A three-molecule score based on Notch pathway predicts poor prognosis in non-metastasis clear cell renal cell carcinoma	期刊论文	Xu, Le\|An, Huimin\|Li, Yanfeng\|Xu, Jiejie\|
47	High CLEC-2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma	期刊论文	Qu, Yang\|Long, Qilai\|Xu, Jiejie\|Guo, Jianming\|
48	High expression of interleukin-11 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma	期刊论文	Liu, Weisi\|Liu, Yidong\|Fu, Qiang\|Xu, Jiejie\|
49	Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3/Snail signaling in renal cell carcinoma	期刊论文	Zhang, Heng\|Liu, Jing\|Xu, Jiejie\|Lin, Zongming\|
50	Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma	期刊论文	Fu, Qiang\|Liu, Haiou\|Zhang, Weijuan\|Xu, Jiejie\|
51	Increased expression of colony stimulating factor-1 is a predictor of poor prognosis in patients with clear-cell renal cell carcinoma	期刊论文	Zhu, Yu\|Liu, Haiou\|Xu, Jiejie\|Gu, Jianxin\|
52	Low Expression of Mucin-4 Predicts Poor Prognosis in Patients With Clear-Cell Renal Cell Carcinoma	期刊论文	Zhou, Lin\|Zhang, Weijuan\|Yang, Yuanfeng\|Xu, Jiejie\|
53	Enhancer of zeste homolog 2 (EZH2) promotes tumour cell migration and invasion via epigenetic repression of E-cadherin in renal cell carcinoma	期刊论文	Jiang, Shuai\|Long, Qilai\|Xu, Jiejie\|Guo, Jianming\|
54	High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection	期刊论文	Cao, Yifan\|Zhang, Weijuan\|Shen, Zhenbin\|Xu, Jiejie\|
55	N-acetylglucosaminyltransferase V confers hepatoma cells with resistance to anoikis through EGFR/PAK1 activation	期刊论文	Liu, Yidong\|Pan, Deng\|Xu, Jiejie\|Gu, Jianxin\|
56	Interleukin-13 receptor alpha 2 is associated with poor prognosis in patients with gastric cancer after gastrectomy	期刊论文	Qin, Jin\|Qin, Xinyu\|Xu, Jiejie\|Sun, Yihong\|
57	Clinical significance of polypeptide N-acetylgalactosaminyl transferase-5 (GalNAc-T5) expression in patients with gastric cancer	期刊论文	Wang, X.\|Tang, Z.\|Xu, J.\|Sun, Y.\|
58	Prognostic Value of Diametrically Polarized Tumor-Associated Macrophages in Renal Cell Carcinoma	期刊论文	Zhang, Weijuan\|Wang, Guomin\|Lin, Zongming\|Xu, Jiejie\|
59	Prognostic significance of beta 1,6-N-acetylglucosaminyltransferase V expression in patients with hepatocellular carcinoma	期刊论文	Liu, Weisi\|Zhang, Weijuan\|Pan, Deng\|Xu, Jiejie\|
60	Infiltration of diametrically polarized macrophages predicts overall survival of patients with gastric cancer after surgical resection	期刊论文	Shen, Zhenbin\|Xu, Jiejie\|Qin, Jing\|Sun, Yihong\|
61	Prognostic value of purinergic P2X7 receptor expression in patients with hepatocellular carcinoma after curative resection	期刊论文	Liu, Yidong\|Zhang, Weijuan\|Xu, Le\|Xu, Jiejie\|
62	Increased expression of MUC3A is associated with poor prognosis in localized clear-cell renal cell carcinoma	期刊论文	Wang, Zewei\|Fu, Hangcheng\|Xu, Jiejie\|Liu, Kun\|
63	Galectin-8 predicts postoperative recurrence of patients with localized T1 clear cell renal cell carcinoma	期刊论文	Zhang, Weijuan\|Liu, Weisi\|Liu, Haiou\|Xu, Jiejie\|
64	Prognostic Value of EZH2 Expression and Activity in Renal Cell Carcinoma: A Prospective Study	期刊论文	Jiang, Shuai\|Long, Qilai\|Xu, Jiejie\|Guo, Jianming\|
65	Increased Expression of CSF-1 Associates With Poor Prognosis of Patients With Gastric Cancer Undergoing Gastrectomy	期刊论文	Qin, Jing\|Qin, Xinyu\|Xu, Jiejie\|Sun, Yihong\|

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