基于人胚胎干细胞诱导分化技术研究SLC30A8对人类胰岛β细胞功能成熟过程的调控机制
31970751
2019
C0709.细胞外微环境与细胞间通讯
李维达
面上项目
教授
同济大学
58万元
单细胞RNA测序;胰岛β细胞;基因编辑;胚胎干细胞(embryonic stem cell);细胞谱系（cell lineage）
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | CD36 deficiency inhibits proliferation by cell cycle control in skeletal muscle cells | 期刊论文 | Jingyu Sun;Yajuan Su;Yaning Xu;Duran Qin;Qianhui He;Haiping Qiu;Jiatong Zhuo;Weida Li |
| 2 | ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes | 期刊论文 | Qing Ma;Yini Xiao;Wenjun Xu;Menghan Wang;Sheng Li;Zhihao Yang;Minglu Xu;Tengjiao Zhang;Zhen-Ning Zhang;Rui Hu;Qiang Su;Fei Yuan;Tinghui Xiao;Xuan Wang;Qing He;Jiaxu Zhao;Zhengjun Chen;Zhejin Sheng;Mengyao Chai;Hong Wang;Weiyang Shi;Qiaolin Deng;Xin Cheng;Weida Li |
| 3 | Wfs1 loss-of-function disrupts the composition of mouse pancreatic endocrine cells from birth and impairs Glut2 localization to cytomembrane in pancreatic β cells | 期刊论文 | Qiang Su;Fei Yuan;Xiaobo Li;Xuan Wang;Kaijiang Yang;Li Shao;Weida Li |
| 4 | Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule | 期刊论文 | Fei Yuan;Yana Li;Rui Hu;Mengting Gong;Mengyao Chai;Xuefei Ma;Jiaxue Cha;Pan Guo;Kaijiang Yang;Mushan Li;Minglu Xu;Qing Ma;Qiang Su;Chuan Zhang;Zhejin Sheng;Heng Wu;Yuan Wang;Wen Yuan;Shan Bian;Li Shao;Ru Zhang;Kaicheng Li;Zhen Shao;Zhen-Ning Zhang;Weida Li |
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