云南崖豆藤属植物中新型抗微管天然活性物质的发现、结构优化、成药性及作用机制研究
U1402222
2014
H3401.合成药物化学
陈俐娟
联合基金项目
教授
四川大学
223万元
成药性;作用机制;崖豆藤属;结构优化;抗微管天然活性物质
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Design, synthesis and antibacterial evaluation of honokiol derivatives | 期刊论文 | Bo Wu;Su-hong Fu;Huan Tang;Kai Chen;Qiang Zhang;Ai-Hua Peng;Hao-Yu Ye;Xing-Jun Cheng;Mao Lian;Zhen-ling Wang;Li-Juan Chen |
| 2 | 嘌呤基-N-羟基嘧啶甲酰胺衍生物及其制备方法和用途 | 专利 | 陈俐娟;魏于全 |
| 3 | 苯并吡喃查尔酮类化合物及其制备方法和用途 | 专利 | 陈俐娟;魏于全 |
| 4 | 4位取代的香豆素衍生物及其制备方法和用途 | 专利 | 陈俐娟;魏于全 |
| 5 | (E)-1-(8-苯并吡喃基)-2-丙烯-1-酮及其类似物以及它们的用途 | 专利 | 陈俐娟;魏于全 |
| 6 | N-(3-哌啶基)-芳香胺衍生物及其制备方法和用途 | 专利 | 陈俐娟;魏于全 |
| 7 | SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines | 期刊论文 | Wei Yan;Tao Yang;Jianhong Yang;Taijin Wang;Yamei Yu;Yuxi Wang;Qiang Chen;Peng Bai;Dan Li;Haoyu Ye;Qiang Qiu;Yongzhao Zhou;Yiguo Hu;Shengyong Yang;Yuquan Wei;Weimin Li;Lijuan Chen |
| 8 | TAK1 inhibition by natural cyclopeptide RA-V promotes apoptosis and inhibits protective autophagy in Kras-dependent non-small-cell lung carcinoma cells | 期刊论文 | Jianhong Yang;Tao Yang;Wei Yan;Dan Li;Fang Wang;Zhe Wang;Yingjie Guo;Peng Bai;Ninghua Tan;Lijuan Chen |
| 9 | The preparation method of (E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and its analogues and their usage | 专利 | 陈俐娟 |
| 10 | Discovery and synthesis of novel magnolol derivatives with potent anticancer activity in non-small cell lung cancer | 期刊论文 | Huan Tang;Yongguang Zhang;Dan Li;Suhong Fu;Minghai Tang;Li Wan;Kai Chen;Zhuowei Liu;Linlin Xue;Aihua Peng;Haoyu Ye;Lijuan Chen |
| 11 | Pironetin reacts covalently with cysteine-316 of alpha-tubulin to destabilize microtubule | 期刊论文 | Yang Jianhong;Wang Yuxi;Wang Taijing;Chen Qiang;Yang Jinliang;Naismith James H.;Chen Lijuan;Yang Jianhong;Wang Yuxi;Wang Taijing;Chen Qiang;Yang Jinliang;Naismith James H.;Chen Lijuan;Yang Jianhong;Wang Yuxi;Wang Taijing;Chen Qiang;Yang Jinliang;Naismith James H.;Chen Lijuan;Jiang Jian;Zhu Xiaofeng;Botting Catherine H.;Liu Huanting;Naismith James H.;Chen LJ;Chen LJ;Chen LJ;Zhu XF |
| 12 | Discovery of novel b-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance | 期刊论文 | Yong Li;Wei Yan;Jianhong Yang;Zhuang Yang;Mengshi Hu;Peng Bai;Minghai Tang;Lijuan Chen |
| 13 | Biodegradable Interlayer-Crosslinked Polymer Micelles with Reduction Sensitivity for Non-Small Cell Lung Cancer Therapy | 期刊论文 | Zhoufeng Wang;Jiaolin Wen;Huili Liu;Li Zheng;Hong Luo;Zhuowei Liu;Xiaoxin Chen;Fang Wang;Dan Li;Heying Pei;Weimin Li;Lijuan Chen |
| 14 | Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening | 期刊论文 | Taijin Wang;Zhuang Yang;Yongguang Zhang;Wei Yan;Fang Wang;Linhong He;Yuanyuan Zhou;Lijuan Chen |
| 15 | Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors | 期刊论文 | Cao Dong;Liu Yibin;Yan Wei;Wang Chunyu;Bai Peng;Wang Taijin;Tang Minghai;Wang Xiaoyan;Yang Zhuang;Lei Lei;Wang Fang;Zhou Yuanyuan;Yang Tao;Chen Lijuan;Cao Dong;Liu Yibin;Yan Wei;Wang Chunyu;Bai Peng;Wang Taijin;Tang Minghai;Wang Xiaoyan;Yang Zhuang;Lei Lei;Wang Fang;Zhou Yuanyuan;Yang Tao;Chen Lijuan;Ma Buyun;Ma Liang;Xu Bixue;Xu Bixue;Chen LJ;Chen LJ |
| 16 | Discovery and synthesis of novel magnolol derivatives with potent anticancer activity in non-small cell lung cancer | 期刊论文 | Huan Tang;Yongguang Zhang;Dan Li;Suhong Fu;Minghai Tang;Li Wan;Kai Chen;Zhuowei Liu;Linlin Xue;Aihua Peng;Haoyu Ye;Lijuan Chen |
| 17 | Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents | 期刊论文 | Zhou Yuanyuan;Yan Wei;Shao Mingfeng;Li Dan;Wang Fang;Yang Zhuang;Chen Yong;He Linhong;Wang Taijin;Shen Mingsheng;Chen Lijuan;Zhou Yuanyuan;Yan Wei;Shao Mingfeng;Li Dan;Wang Fang;Yang Zhuang;Chen Yong;He Linhong;Wang Taijin;Shen Mingsheng;Chen Lijuan;Zhou Yuanyuan;Yan Wei;Shao Mingfeng;Li Dan;Wang Fang;Yang Zhuang;Chen Yong;He Linhong;Wang Taijin;Shen Mingsheng;Chen Lijuan;Cao Dong... |
| 18 | 1-(嘧啶-4-基)3-胺基哌啶衍生物及其制备方法和用途 | 专利 | 陈俐娟;魏于全 |
| 19 | Flavonoids and biphenylneolignans with anti-inflammatory activity from the stems of Millettia griffithii | 期刊论文 | Tang Huan;Pei He-Ying;Wang Tai-Jin;Chen Kai;Wu Bo;Zhang Qiang;Yang Jian-Hong;Wang Xiao-Yan;Tang Ming-Hai;Peng Ai-Hua;Ye Hao-Yu;Chen Li-Juan;Tang Huan;Pei He-Ying;Wang Tai-Jin;Chen Kai;Wu Bo;Zhang Qiang;Yang Jian-Hong;Wang Xiao-Yan;Tang Ming-Hai;Peng Ai-Hua;Ye Hao-Yu;Chen Li-Juan;Tang Huan;Pei He-Ying;Wang Tai-Jin;Chen Kai;Wu Bo;Zhang Qiang;Yang Jian-Hong;Wang Xiao-Yan;Tang Ming-Hai... |
| 20 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin. | 期刊论文 | Yang Jianhong;Yan Wei;Yu Yamei;Wang Yuxi;Yang Tao;Xue Linlin;Yuan Xue;Long Caofeng;Liu Zuowei;Chen Xiaoxin;Hu Mengshi;Zheng Li;Qiu Qiang;Pei Heying;Li Dan;Wang Fang;Bai Peng;Wen Jiaolin;Ye Haoyu;Chen Lijuan |
| 21 | Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-kappa B pathway in ovarian cancer | 期刊论文 | Wu Wenshuang;Ma Buyun;Ye Haoyu;Wang Taijin;Wang Xiaoyan;Yang Jianhong;Wei Yuquan;Zhu Jingqiang;Chen Lijuan |
| 22 | Identification of compounds with cytotoxic activity from Millettia dorwardi Coll. Et. Hemsl | 期刊论文 | Kai Chen;Huan Tang;Li Zheng;Lun Wang;Linlin Xue;Ai-hua Peng;Ming-hai Tang;Chaofeng Long;Xiaoxin Chen;Hao-yu Ye;Li-juan Chen |
| 23 | SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules | 期刊论文 | Fang Wang;Li Zheng;Yuyao Yi;Zhuang Yang;Qiang Qiu;Xiaoyan Wang;Wei Yan;Peng Bai;Jianhong Yang;Dan Li;Heying Pei;Ting Niu;Haoyu Ye;Chunlai Nie;Yiguo Hu;Shengyong Yang;Yuquan Wei;Lijuan Chen |
| 24 | Phytochemical investigation of Millettia dorwardi Coll. et Hemsl | 期刊论文 | Kai Chen;Huan Tang;Bo Wu;Shucai Li;Aihua Peng;Haoyu Ye;Lijuan Chen |
查看更多信息请先登录或注册
