新型天然二萜生物碱先导物的发现、结构优化及靶向SIRT3抗乳腺癌机制研究

81903502
2019
H3402.天然药物化学
张吉发
青年科学基金项目
副研究员
四川大学
20万元
SIRT3;二萜生物碱;结构修饰;乳腺癌;自噬性细胞死亡
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Dual-target inhibitors of poly (ADP-ribose) polymerase-1 for cancer therapy: Advances, challenges, and opportunities 期刊论文 Hu Xinyue;Zhang Jifa;Zhang Ya;Jiao Fulun;Wang Jiaxing;Chen Hao;Ouyang Liang;Wang Yuxi
2 Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development 期刊论文 Tang Pan;Zhang Jifa;Liu Jie;Chiang Cheng Ming;Ouyang Liang
3 Discovery of 4-Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy 期刊论文 Zhang Jifa;Yang Chengcan;Tang Pan;Chen Juncheng;Zhang Dan;Li Yang;Yang Gaoxia;Liu Yun;Zhang Yiwen;Wang Yuxi;Liu Jie;Ouyang Liang
4 DYRK1A Inhibitors for Disease Therapy: Current Status and Perspectives 期刊论文 Liu Tong;Wang Yuxi;Wang Jiaxing;Ren Changyu;Chen Hao;Zhang Jifa
5 Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives 期刊论文 Zhang Lele;Zhang Jifa;Wang Jiaxing;Ren Changyu;Tang Pan;Ouyang Liang;Wang Yuxi
6 一类结构新颖的C19二萜生物碱及其用途 专利 周先礼;张吉发;高峰;黄帅;单连海
7 Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer 期刊论文 Zhang Jin;Zou Ling;Shi Danfeng;Liu Jie;Zhang Jifa;Zhao Rongyan;Wang Guan;Zhang Lan;Ouyang Liang;Liu Bo
8 Discovery, Synthesis, and Evaluation of Highly Selective Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) Inhibitor for the Potential Treatment of Metastatic Triple-Negative Breast Cancer 期刊论文 Li Yang;Yang Gaoxia;Zhang Jifa;Tang Pan;Yang Chengcan;Wang Guan;Chen Juncheng;Liu Jie;Zhang Lan;Ouyang Liang
9 Current progress and novel strategies that target CDK12 for drug discovery 期刊论文 Lei Peng;Zhang Jifa;Liao Peiyu;Ren Changyu;Wang Jiaxing;Wang Yuxi
10 新型喹唑啉类小分子抑制剂及其在抗肿瘤药物中的应用 专利 欧阳亮;张吉发
11 一种噻吩并喹啉酮类化合物及其抗肿瘤应用 专利 张吉发
12 Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy 期刊论文 Tan Lun;Zhang Jifa;Wang Yuxi;Wang Xiye;Wang Yanyan;Zhang Zhixiong;Shuai Wen;Wang Guan;Chen Juncheng;Wang Chengdi;Ouyang Liang;Li Weimin
13 Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential 期刊论文 Zhang Jifa;Zhang Lele;Wang Jiaxing;Ouyang Liang;Wang Yuxi
14 Repurposing drugs in autophagy for the treatment of cancer: From bench to bedside 期刊论文 Bu Faqian;Zhang Jifa;Shuai Wen;Liu Jie;Sun Qiu;Ouyang Liang
15 Proteolysis-targeting chimeras in breast cancer therapy. 期刊论文 Zhang Jifa;Ouyang Liang
16 Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy 期刊论文 Zhang Jifa;Tang Pan;Zou Ling;Zhang Jin;Chen Juncheng;Yang Chengcan;He Gu;Liu Bo;Liu Jie;Chiang Cheng-Ming;Wang Guan;Ye Tinghong;Ouyang Liang
17 Targeting autophagy-related protein kinases for potential therapeutic purpose 期刊论文 Xiang Honggang;Zhang Jifa;Lin Congcong;Zhang Lan;Liu Bo;Ouyang Liang
18 Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives 期刊论文 Zhang Ya;Zhang Jifa;Wang Jiaxing;Chen Hao;Ouyang Liang;Wang Yuxi
19 Targeting EZH2 for cancer therapy: From current progress to novel strategies 期刊论文 Zeng Jia;Zhang Jifa;Sun Ying;Wang Jiaxing;Ren Changyu;Banerjee Souvik;Ouyang Liang;Wang Yuxi
20 Identification and optimization of 3-bromo-N'-(4-hydroxybenzylidene)-4-methylbenzohydrazide derivatives as mTOR inhibitors that induce autophagic cell death and apoptosis in triple-negative breast cancer 期刊论文 Xu Tian;Zhang Jifa;Yang Chengcan;Pluta Ryszard;Wang Guan;Ye Tinghong;Ouyang Liang
21 Small-Molecule Receptor-Interacting Protein 1 (RIP1) Inhibitors as Therapeutic Agents for Multifaceted Diseases: Current Medicinal Chemistry Insights and Emerging Opportunities 期刊论文 Shi Kunyu;Zhang Jifa;Zhou Enda;Wang Jiaxing;Wang Yuxi
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