肿瘤靶向药物及siRNA联合传输多功能纳米载体研究

50830107
2008
E0308.生物医用有机高分子材料
帅心涛
重点项目
教授
中山大学
200万元
药物化疗;肿瘤抗药;药物和siRNA双载体;肿瘤靶向;基因治疗
2009-01-01到2012-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells 期刊论文 Cao, N|Cheng, D|Zou, SY|Ai, H|Gao, JM|Shuai, XT|
2 Dynamic-Light-Scattering-Based Sequence-Specific Recognition of Double-Stranded DNA with Oligonucleotide-Functionalized Gold Nanoparticles 期刊论文 Miao, XM|Xiong, C|Wang, WW|Ling, LS|Shuai, XT|
3 Matrix polyelectrolyte capsules based on polysaccharide/MnCO3 hybrid microparticle templates 期刊论文 Wei, Qingrong|Ai, Hua|Gu, Zhongwei|
4 Rigid Mn(II) chelate as efficient MRI contrast agent for vascular imaging 期刊论文 Su, Hongying|Ai, Hua|Wu, Changqiang|Zhu, Jiang|Miao, Tianxin|Wang, Dan|Xia, Chunchao|Zhao, Xuna|Gong, Qiyong|Song, Bin|
5 Targeting EGFR-overexpressing tumor cells using Cetuximab-immunomicelles loaded with doxorubicin and superparamagnetic iron oxide 期刊论文 Liao, CD|Sun, QQ|Liang, BL|Shen, J|Shuai, XT|
6 Multifunctional gadolinium-based dendritic macromolecules as liver targeting imaging probes 期刊论文 Luo, Kui|Liu, Gang|He, Bin|Wu, Yao|Gong, Qingyong|Song, Bin|Ai, Hua|Gu, Zhongwei|
7 Detection of Pb2+ at attomole levels by using dynamic light scattering and unmodified gold nanoparticles 期刊论文 Miao, Xiang-Min|Ling, Lian-Sheng|Shuai, Xin-Tao|
8 Magnetic resonance imaging probes for labeling of chondrocyte cells 期刊论文 Liu, Gang|Xia, Chunchao|Wang, Zhiyong|Lv, Fei|Gao, Fabao|Gong, Qiyong|Song, Bin|Ai, Hua|Gu, Zhongwei|
9 Cell labeling efficiency of layer-by-layer self-assembly modified silica nanoparticles 期刊论文 Liu, Gang|Tian, Jing|Liu, Chen|Ai, Hua|Gu, Zhongwei|Gou, Jilong|Mo, Xianming|
10 Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat 期刊论文 Cheng, D|Cao, N|Chen, JF|Yu, XS|Shuai, XT|
11 Nanobubbles for enhanced ultrasound imaging of tumors 期刊论文 Yin, TH|Wang, P|Zheng, RQ|Zheng, BW|Cheng, D|Zhang, XL|Shuai, XT|
12 Ultrasensitive detection of lead(II) with DNAzyme and gold nanoparticles probes by using a dynamic light scattering technique 期刊论文 Miao, XM|Ling, LS|Shuai, XT|
13 Layer-by-layer capsules for magnetic resonance imaging and drug delivery 期刊论文 Ai, Hua|
14 Synthesis and characterization of polycation block copolymer Poly(L-lysine)-b-poly[N-(N ';,N ';-diisopropyl-aminoethyl)aspartamide] as potential pH responsive gene delivery system 期刊论文 Guo, CP|Chen, WC|Lin, SD|Li, H|Cheng, D|Wang, XY|Shuai, XT|
15 Design of Multifunctional Micelle for Tumor-Targeted Intracellular Drug Release and Fluorescent Imaging 期刊论文 Wang, WW|Cheng, D|Gong, FM|Miao, XM|Shuai, XT|
16 Surface-Engineered Magnetic Nanoparticle Platforms for Cancer Imaging and Therapy 期刊论文 Xie, Jin|Liu, Gang|Eden, Henry S.|Ai, Hua|Chen, Xiaoyuan|
17 Development of an MRI-visible nonviral vector for siRNA delivery targeting gastric cancer 期刊论文 Chen, YT|Huang, KH|Shuai, XT|Wang, WW|Lian, GD|Qian, CC|Wang, LY|Zeng, LJ|Liao, CD|Liang, BL|Huang, B|
18 A pH-sensitive polymeric nanovesicle based on biodegradable poly(ethylene glycol)-b-poly(2-(diisopropylamino)ethyl aspartate) as a MRI-visible drug delivery system 期刊论文 Sun, QQ|Cheng, D|Yu, XS|Zhang, ZQ|Dai, J|Li, H|Liang, BL|Shuai, XT|
19 Controllable labelling of stem cells with a novel superparamagnetic iron oxide-loaded cationic nanovesicle for MR imaging 期刊论文 Guo, Ruo Mi|Cao, Nuo|Zhang, Fang|Wang, Yi Ru|Wen, Xue Hua|Shen, Jun|Shuai, Xin Tao|
20 Amphiphilic Toothbrushlike Copolymers Based on Poly(ethylene glycol) and Poly(epsilon-caprolactone) as Drug Carriers with Enhanced Properties 期刊论文 Zhang, WL|Li, YL|Liu, LX|Sun, QQ|Shuai, XT|Zhu, W|Chen, YM|
21 Sensitive detection of glucose in human serum with oligonucleotide modified gold nanoparticles by using dynamic light scattering technique 期刊论文 Miao Xiangmin|Ling Liansheng|Shuai Xintao|
22 Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release 期刊论文 Dai, J|Lin, SD|Cheng, D|Zou, SY|Shuai, XT|
23 Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging 期刊论文 Liu, G|Chen, XY|Ai, H|Gu, ZW|Wang, ZY|Lu, Ji|Xia, CC|Gao, FB|Gong, QY|Song, B|Zhao, XN|Shuai, XT|
24 Simultaneous diagnosis and gene therapy of immuno-rejection in rat allogeneic heart transplantation model using a T-cell-targeted theranostic nanosystem 期刊论文 Guo Yu|Shuai Xintao|Chen Wenjie|Wang Weiwei|Shen Jun|Guo Ruomi|Gong Faming|Lin Shudong|Cheng Du|Chen Guihua|
25 Enhanced apoptosis of ovarian cancer cells via nanocarrier-mediated codelivery of siRNA and doxorubicin 期刊论文 Zou, Seyin|Cao, Nuo|Cheng, Du|Zheng, Rongqin|Wang, Jin|Zhu, Kangshun|Shuai, Xintao|
26 N-Alkyl-PEI-Functionalized Iron Oxide Nanoclusters for Efficient siRNA Delivery 期刊论文 Liu, Gang|Ai, Hua|Chen, Xiaoyuan|Xie, Jin|Zhang, Fan|Wang, Zhiyong|Luo, Kui|Zhu, Lei|Quan, Qimeng|Niu, Gang|Lee, Seulki|
27 Nonclustered magnetite nanoparticle encapsulated biodegradable polymeric micelles with enhanced properties for in vivo tumor imaging 期刊论文 Cheng, D|Hong, GB|Wang, WW|Yuan, RX|Ai, H|Shen, J|Liang, BL|Shuai, XT|
28 Amphiphilic starlike dextran wrapped superparamagnetic iron oxide nanoparticle clsuters as effective magnetic resonance imaging probes 期刊论文 Su Hongying|Liu Yanhong|Wang Dan|Wu Changqiang|Xia Chunchao|Gong Qiyong|Song Bin|Ai Hua|
29 Hepatocyte-targeted psiRNA Delivery Mediated by Galactosylated Poly(Ethylene Glycol)-Graft-Polyethylenimine In Vitro 期刊论文 Nie, CF|Liu, CT|Chen, GH|Dai, J|Li, H|Shuai, XT|
30 Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes 期刊论文 Wang QiaoYing|Ai Hua|Gu ZhongWei|Su HongYing|Xia ChunChao|Sun JiaYu|Liu Chen|Wang ZhiYong|Gong QiYong|Song Bin|Gao FaBao|
31 Applications and Potential Toxicity of Magnetic Iron Oxide Nanoparticles 期刊论文 Liu Gang|Gao Jinhao|Ai Hua|Chen Xiaoyuan|
32 Gadolinium-labeled peptide dendrimers with controlled structures as potential magnetic resonance imaging contrast agents 期刊论文 Luo, Kui|Gu, Zhongwei|Liu, Gang|She, Wenchuan|Wang, Qiaoying|Wang, Gang|He, Bin|Ai, Hua|Gong, Qiyong|Song, Bin|
33 A highly sensitive sensor for Cu2+ with unmodified gold nanoparticles and DNAzyme by using the dynamic light scattering technique 期刊论文 Miao, Xiangmin|Ling, Liansheng|Cheng, Du|Shuai, Xintao|
34 Near-infrared fluorescent amphiphilic polycation wrapped magnetite nanoparticles as multimodality probes 期刊论文 Wang Dan|Ai Hua|Su Hongying|Liu Yanhong|Wu Changqiang|Xia Chunchao|Sun Jiayu|Gao Fabao|Gong Qiyong|Songbin|
35 Polyethylenimine-grafted copolymer of poly(L-lysine) and poly(ethylene glycol) for gene delivery 期刊论文 Dai, J|Zou, SY|Pei, YY|Cheng, D|Ai, H|Shuai, XT|
36 Matrix polyelectrolyte capsules based on polysaccharide/MnCO3 hybrid microparticle templates 期刊论文 Wei, Qingrong|Ai, Hua|Gu, Zhongwei|
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