受体酪氨酸激酶对肿瘤靶向治疗耐药性进展过程调控机理研究
81773752
2017
H3505.抗肿瘤药物药理
石虎兵
面上项目
研究员
四川大学
60万元
BRAF;分子靶向治疗;耐药性;黑色素瘤;抗肿瘤药物药理
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer. | 期刊论文 | Chune Yu;Dan Luo;Jing Yu;Min Zhang;Xiaobo Zheng;Guangchao Xu;Jiaxin Wang;Huiling Wang;Yufei Xu;Ke Jiang;Jie Xu;Xuelei Ma;Jing Jing;Hubing Shi |
| 2 | Inhibition Mechanism of Indoleamine 2, 3-Dioxygenase 1 (IDO1) by Amidoxime Derivatives and Its Revelation in Drug Design: Comparative Molecular Dynamics Simulations | 期刊论文 | Liu Xinyu;Zhang Yiwen;Duan Huaichuan;Luo Qing;Liu Wei;Liang Li;Wan Hua;Chang Shan;Hu Jianping;Shi Hubing |
| 3 | Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours | 期刊论文 | Yao Han;Lan Jiang;Li Chushu;Shi Hubing;Brosseau Jean-Philippe;Wang Huanbin;Lu Haojie;Fang Caiyun;Zhang Yao;Liang Lunxi;Zhou Xiaolin;Wang Chaojun;Xue Yu;Cui Yun;Xu Jie |
| 4 | The global motion affecting electron transfer in Plasmodium falciparum type II NADH dehydrogenases: a novel non-competitive mechanism for quinoline ketone derivative inhibitors | 期刊论文 | Xie Tao;Wu Zhixiang;Gu Jinke;Guo Runyu;Yan Xiao;Duan Huaichuan;Liu Xinyu;Liu Wei;Liang Li;Wan Hua;Luo Yafei;Tang Dianyong;Shi Hubing;Hu Jianping |
| 5 | Inhibition of programmed cell death protein ligand-1 (PD-L1) by benzyl ether derivatives: analyses of conformational change, molecular recognition and binding free energy | 期刊论文 | Sun Xin;Liang Li;Gu Jinke;Zhuo Wei;Yan Xiao;Xie Tao;Wu Zhixiang;Liu Xinyu;Gou Xiaojun;Liu Wei;He Gang;Gan Ya;Chang Shan;Shi Hubing;Hu Jianping |
| 6 | MAPK-Targeted Drug Delivered by a pH-Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-Cell Suppression | 期刊论文 | Liu Xiaowei;Feng Yanlin;Xu Guangchao;Chen Yang;Luo Ya;Song Jinen;Bao Yu;Yang Jiqiao;Yu Chune;Li Yanna;Ye Haoyu;Ke Bowen;Chen Bo;Hu Jianping;Xu Jie;Meng Huan;Zhang Haiyuan;Shi Hubing |
| 7 | Improvement of PD-1 Blockade Efficacy and Elimination of Immune-Related Gastrointestinal Adverse Effect by mTOR Inhibitor. | 期刊论文 | Xin Bai;Xueyan Wang;Guozhen Ma;Jinen Song;Xiaowei Liu;Xi Wu;Yujie Zhao;Xu Liu;Zhihui Liu;Wei Zhang;Xin Zhao;Zirui Zheng;Jing Jing;Hubing Shi |
| 8 | Combination of MAPK inhibition with photothermal therapy synergistically augments the anti-tumor efficacy of immune checkpoint blockade. | 期刊论文 | Xiaowei Liu;Yanlin Feng;Jie Xu;Ying Shi;Jiqiao Yang;Rongjie Zhang;Jinen Song;Xin Bai;Xi Wu;Yu Bao;Ya Luo;Huifang Li;Li Chai;Changyang Gong;Yan Wang;Bo Chen;Jianping Hu;Yan Fu;Yongzhang Luo;Haiyuan Zhang;Hubing Shi |
| 9 | Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy. | 期刊论文 | Chune Yu;Min Zhang;Jinen Song;Xiaobo Zheng;Guangchao Xu;Yu Bao;Jiang Lan;Dan Luo;Jianping Hu;Jingyi Jessica Li;Hubing Shi |
| 10 | AIDE: annotation-assisted isoform discovery with high precision | 期刊论文 | Li Wei Vivian;Li Shan;Tong Xin;Deng Ling;Shi Hubing;Li Jingyi Jessica |
| 11 | The evolution of acquired resistance to BRAF inhibitor is sustained by IGF1-driven tumor vascular remodeling. | 期刊论文 | Guangchao Xu;Ya Luo;Wenshuang Wu;Xiaowei Liu;Xin Yu;Yu Bao;Xiujing He;Jing Yu;Yanna Li;Jiqiao Yang;Rongjie Zhang;Chune Yu;Hongying Chen;Jie Xu;Jianping Hu;Jing Jing;Hubing Shi |
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