基于结构生物学的Taccalonolide AN 衍生物的设计、合成及抗肿瘤活性研究
81872907
2018
H3505.抗肿瘤药物药理
杨金亮
面上项目
教授
四川大学
60万元
结构生物学;箭根酮内酯;弹头药物;抗体-药物偶联物
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma | 期刊论文 | Tao Y;Wang R;Lai Q;Wu M;Wang Y;Jiang X;Zeng L;Zhou S;Li Z;Yang T;Yao Y;Wu Y;Yu L;Fu Y;Lai W;Peng Y;Lu Y;Zhang Z;Guo C;Zhang G;Gou L;Yang J |
| 2 | Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies | 期刊论文 | Lai Qinhuai;Wu Mengdan;Wang Ruixue;Lai Weirong;Tao Yiran;Lu Ying;Wang Yuxi;Yu Lin;Zhang Ruirui;Peng Yujia;Jiang Xiaohua;Fu Yuyin;Wang Xin;Zhang Zhixiong;Guo Cuiyu;Liao Wei;Zhang Yiwen;Kang Tairan;Chen Hao;Yao Yuqin;Gou Lantu;Yang Jinliang |
| 3 | Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine–Anthracenecarboxyimide as a Payload for Antibody–Drug Conjugate | 期刊论文 | Weirong Lai;Shengyan Zhao;Qinhuai Lai;Wei Zhou;Mengdan Wu;Xiaohua Jiang;Xin Wang;Yujia Peng;Xian Wei;Liang Ouyang;Lantu Gou;Hao Chen;Yuxi Wang;Jinliang Yang |
| 4 | FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma | 期刊论文 | Guangbing Zhang;Cuiyu Guo;Yan Wang;Xianda Zhang;Shuang Liu;Wen Qu;Chunxia Chen;Lingli Yan;Zhouning Yang;Zhixiong Zhang;Xiaohua Jiang;Xiaofeng Chen;Hong Liu;Qinhuai Lai;Xian Wei;Ying Lu;Shengyan Zhao;Han Deng;Yuxi Wang;Lin Yu;Hongbin Yu;Yu Wu;Zhaoming Su;Pengyu Chen;Ziqing Ren;Meng Yu;Feng Qu;Yong Luo;Lantu Gou;Qing Li;Ying Huang;Fanxin Ma;Jinliang Yang |
| 5 | Effective antitumor activity of 5T4‐specific CAR‐T cells against ovarian cancer cells in vitro and xenotransplanted tumors in vivo | 期刊论文 | Cuiyu Guo;E Dong;Qinhuai Lai;Shijie Zhou;Guangbing Zhang;Mengdan Wu;Xiaozhu Yue;Yiran Tao;Yujia Peng;Jamel Ali;Ying Lu;Yuyin Fu;Weirong Lai;Zhixiong Zhang;Fanxin Ma;Yuqin Yao;Lantu Gou;Hanshuo Yang;Jinliang Yang |
| 6 | 吡咯并苯并二氮杂卓-蒽酰亚胺杂交分子及其制备方法和用途 | 专利 | 赖伟荣;赵盛炎;赖钦淮;陈浩;勾蓝图;王誉熹;杨金亮 |
查看更多信息请先登录或注册
