Sirt6调节TGF-beta信号通路及其在肝脏疾病中的作用机制研究
81870599
2018
H0707.糖稳态失衡与靶器官胰岛素抵抗
李艳萍
面上项目
副研究员
四川大学
57万元
肝纤维化;肝脏疾病;肝星状细胞;TGF-beta信号通路;Sirt6
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis | 期刊论文 | Pu Shiyun;Li Yanping;Liu Qinhui;Zhang Xu;Chen Lei;Li Rui;Zhang Jinhang;Wu Tong;Tang Qin;Yang Xuping;Zhang Zijing;Huang Ya;Kuang Jiangying;Li Hong;Zou Min;Jiang Wei;He Jinhan |
| 2 | Mesencephalic astrocyte‐derived neurotrophic factor alleviates non‐alcoholic steatohepatitis induced by Western diet in mice | 期刊论文 | Jiamin Yan;Qinhui Liu;Qin Tang;Jinhang Zhang;Xiandan Jing;Yan Xia;Ying Xu;Jiahui Li;Yanping Li;Jinhan He |
| 3 | 用于防治肥胖的中脑星形胶质细胞源性神经营养因子的融合蛋白 | 专利 | 何金汗;李艳萍;吴桐 |
| 4 | SB431542-Loaded Liposomes Alleviate Liver Fibrosis by Suppressing TGF-β Signaling | 期刊论文 | Zhang Jinhang;Li Rui;Liu Qinhui;Zhou Jian;Huang Hui;Huang Ya;Zhang Zijing;Wu Tong;Tang Qin;Huang Cuiyuan;Zhao Yingnan;Zhang Guorong;Mo Li;Li Yanping;He Jinhan |
| 5 | Mixed micelles loaded with the 5-benzylidenethiazolidine-2,4-dione derivative SKLB023 for efficient treatment of non-alcoholic steatohepatitis | 期刊论文 | Li Yanping;Zhang Ting;Liu Qinhui;Zhang Jinhang;Li Rui;Pu Shiyun;Wu Tong;Ma Liang;He Jinhan |
| 6 | Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway | 期刊论文 | Wu Tong;Liu Qinhui;Li Yanping;Li Hong;Chen Lei;Yang Xuping;Tang Qin;Pu Shiyun;Kuang Jiangying;Li Rui;Huang Ya;Zhang Jinhang;Zhang Zijing;Zhou Jian;Huang Cuiyuan;Zhang Guorong;Zhao Yingnan;Zou Min;Jiang Wei;Mo Li;He Jinhan |
| 7 | SKLB023 混合胶束及其制备方法和用途 | 专利 | 何金汗;李艳萍;马良;莫莉 |
| 8 | Inhibition of the sodium-glucose co-transporter SGLT2 by canagliflozin ameliorates diet-induced obesity by increasing intra-adipose sympathetic innervation | 期刊论文 | Yang Xuping;Liu Qinhui;Li Yanping;Ding Yi;Zhao Yan;Tang Qin;Wu Tong;Chen Lei;Pu Shiyun;Cheng Shihai;Zhang Jinhang;Zhang Zijing;Huang Ya;Li Rui;Zhao Yingnan;Zou Min;Shi Xiongjie;Jiang Wei;Wang Rui;He Jinhan |
| 9 | Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells | 期刊论文 | Zhang Jinhang;Li Yanping;Liu Qinhui;Huang Ya;Li Rui;Wu Tong;Zhang Zijing;Zhou Jian;Huang Hui;Tang Qin;Huang Cuiyuan;Zhao Yingnan;Zhang Guorong;Jiang Wei;Mo Li;Zhang Jian;Xie Wen;He Jinhan |
| 10 | Novel Therapeutic Targets in Liver Fibrosis | 期刊论文 | Zhang Jinhang;Liu Qinhui;He Jinhan;Li Yanping |
| 11 | An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis | 期刊论文 | Li Yanping;Pu Shiyun;Liu Qinhui;Li Rui;Zhang Jinhang;Wu Tong;Chen Lei;Li Hong;Yang Xuping;Zou Min;Xiao Jia;Xie Wen;He Jinhan |
| 12 | Hepatocyte-specific deletion of Nlrp6 in mice exacerbates the development of non-alcoholic steatohepatitis | 期刊论文 | Huang Cuiyuan;Liu Qinhui;Tang Qin;Jing Xiandan;Wu Tong;Zhang Jinhang;Zhang Guorong;Zhou Jian;Zhang Zijing;Zhao Yingnan;Huang Hui;Xia Yan;Yan Jiamin;Xiao Jia;Li Yanping;He Jinhan |
| 13 | 靶向棕色脂肪组织的递药系统 | 专利 | 何金汗;李艳萍;莫莉 |
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