基于结构生物学的Tubulysin衍生物的设计、合成及抗肿瘤活性研究
81703553
2017
H3505.抗肿瘤药物药理
王誉熹
青年科学基金项目
研究员
四川大学
20万元
肿瘤药理学;结构生物学;构效关系;抗体-药物偶联物;弹头
2018-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design | 期刊论文 | Chengyong Wu;Jinghong Xian;Yanyan Wang;QingJie Xiao;Lingling Ma;Yuyan Li;Hai Chen;Qian Lei;Quan Zhang;Bo Sun;Yuxi Wang |
| 2 | High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design | 期刊论文 | Qingjie Xiao;Ting Xue;Wen Shuai;Chengyong Wu;Zhixiong Zhang;Ting Zhang;Shaoxue Zeng;Bo Sun;Yuxi Wang |
| 3 | A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance | 期刊论文 | Arnst Kinsie E.;Wang Yuxi;Hwang Dong-Jin;Xue Yi;Costello Terry;Hamilton David;Chen Qiang;Yang Jinliang;Park Frank;Dalton James T.;Miller Duane D.;Li Wei |
| 4 | Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities | 期刊论文 | Li Gang;Wang Yuxi;Li Ling;Ren Yichang;Deng Xin;Liu Jin;Wang Wei;Luo Meihua;Liu Shuwen;Chen Jianjun |
| 5 | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy | 期刊论文 | Banerjee Souvik;Arnst Kinsie E;Wang Yuxi;Kumar Gyanendra;Deng Shanshan;Yang Lei;Li Guo bo;Yang Jinbang;White Stephen W;Li Wei;Miller Duane D |
| 6 | Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design | 期刊论文 | Cheng Jie;Wu Yangping;Wang Yuxi;Wang Chengdi;Wang Yanyan;Wu Chengyong;Zeng Shaoxue;Yu Yamei;Chen Qiang |
| 7 | Colchicine binding site agent DJ95 overcomes drug resistance and exhibits antitumor efficacy | 期刊论文 | Kinsie E.Arnst;Yuxi Wang;Zi-Ning Lei;Dong-Jin Hwang;Gyanendra Kumar;Dejian Ma;Deanna N.Parke;Qiang Chen;Jinliang Yang;Stephen W.White;Tiffany N.Seagroves;Zhe-Sheng Chen;Duane D.Miller;Wei Li |
| 8 | 微管抑制剂及其制备方法和用途 | 专利 | 赖钦淮;陈浩;苏小兰;王誉熹;姚于勤;杨金亮 |
| 9 | 驱动蛋白超家族作为肺癌潜在生物标志物和治疗靶点的研究进展 | 期刊论文 | 杨阳;马宇星;梁艺颖;王誉熹 |
| 10 | Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies | 期刊论文 | Lai Qinhuai;Wu Mengdan;Wang Ruixue;Lai Weirong;Tao Yiran;Lu Ying;Wang Yuxi;Yu Lin;Zhang Ruirui;Peng Yujia;Jiang Xiaohua;Fu Yuyin;Wang Xin;Zhang Zhixiong;Guo Cuiyu;Liao Wei;Zhang Yiwen;Kang Tairan;Chen Hao;Yao Yuqin;Gou Lantu;Yang Jinliang |
| 11 | Targeting of DDR 1 with antibody‐drug conjugates has antitumor effects in a mouse model of colon carcinoma | 期刊论文 | Yiran Tao;Ruixue Wang;Qinhuai Lai;Mengdan Wu;Yuxi Wang;Xiaohua Jiang;Lishi Zeng;Shijie Zhou;Zhongping Li;Tinghan Yang;Yuqin Yao;Yangping Wu;Lin Yu;Yuyin Fu;Weirong Lai;Yujia Peng;Ying Lu;Zhixiong Zhang;Cuiyu Guo;Guangbing Zhang;Lantu Gou;Jinliang Yang |
| 12 | Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities | 期刊论文 | Wang Qinghui;Arnst Kinsie E.;Wang Yuxi;Kumar Gyanendra;Ma Dejian;Chen Hao;Wu Zhongzhi;Yang Jinliang;White Stephen W.;Miller Duane D.;Li Wei |
| 13 | Molecular mechanism of crolibulin in complex with tubulin provides a rationale for drug design | 期刊论文 | Zhang Zhixiong;Wang Chengdi;Ma Lingling;Jiang Xiaohua;Wu Chengyong;Wang Yanyan;Jiang Yuting;Zheng Wenyue;Yang Yang;Ma Yuxing;Yang Jinliang |
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