靶向eEF2K化合物抑制三阴性乳腺癌保护性自噬和诱导凋亡的机制

81673455
2016
H3505.抗肿瘤药物药理
刘博
面上项目
研究员
四川大学
50万元
三阴性乳腺癌;靶向eEF2K化合物;自噬;凋亡;eEF2K
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Discovery of a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer 期刊论文 Rongyan Zhao;Leilei Fu;Zhaoxin Yuan;Yi Liu;Kai Zhang;Yanmei Chen;Leiming Wang;Dejuan Sun;Lixia Chen;Bo Liu;Lan Zhang
2 UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target 期刊论文 Zhang Lan;Ouyang Liang;Guo Yongzhi;Zhang Jin;Liu Bo
3 Autophagic compound database: A resource connecting autophagy-modulating compounds, their potential targets and relevant diseases 期刊论文 Deng Yiqi;Zhu Lingjuan;Cai Haoyang;Wang Guan;Liu Bo
4 自噬启动因子ULK1的生物学功能与靶向治疗研究进展 期刊论文 张岚;欧阳亮;刘博
5 Designing an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells 期刊论文 Yao Liu;Yongqi Zhen;Guan Wang;Gaoxia Yang;Leilei Fu;Bo Liu;Liang Ouyang
6 Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo 期刊论文 Zhang Lan;Fu Leilei;Zhang Shouyue;Zhang Jin;Zhao Yuqian;Zheng Yaxin;He Gu;Yang Shengyong;Ouyang Liang;Liu Bo
7 Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma 期刊论文 Shouyue Zhang;Jin Zhang;Yang An;Xiaoxi Zeng;Ziyi Qin;Yuqian Zhao;Heng Xu;Bo Liu
8 Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target 期刊论文 Jin Zhang;Honggang Xiang;Jie Liu;Yi Ch;Rong-Rong He;Bo Liu
9 Deciphering the Rules of in Silico Autophagy Methods for Expediting Medicinal Research 期刊论文 Chen Yi;Wang Guan;Cai Haoyang;Sun Yang;Ouyang Liang;Liu Bo
10 Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications 期刊论文 Huidan Tan;Shouyue Zhang;Lingjuan Zhu;Jin Zhang;Bo Liu
11 Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer 期刊论文 Ouyang Liang;Zhang Lan;Liu Jie;Fu Leilei;Yao Dahong;Zhao Yugian;Zhang Shouyue;Wang Guan;He Gu;Liu Bo
12 Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy 期刊论文 Zhang Jin;Wang Guan;Zhou Yuxin;Chen Yi;Ouyang Liang;Liu Bo
13 A small-molecule activator induces ULK1-modulating autophagy-associated cell death in triple negative breast cancer 期刊论文 Ouyang Liang;Zhang Lan;Fu Leilei;Liu Bo
14 Targeting autophagy-related protein kinases for potential therapeutic purpose 期刊论文 Honggang Xiang;Jifa Zhang;Congcong Lin;Lan Zhang;Bo Liu;Liang Ouyang
15 Discovery of Thieno[2,3-d]pyrimidine-Based Hydroxamic Acid Derivatives as Bromodomain-Containing Protein 4/Histone Deacetylase Dual Inhibitors Induce Autophagic Cell Death in Colorectal Carcinoma Cells 期刊论文 Pan Zhaoping;Li Xiang;Wang Yujia;Jiang Qinglin;Jiang Li;Zhang Min;Zhang Nan;Wu Fengbo;Liu Bo;He Gu
16 Dual-target kinase drug design: Current strategies and future directions in cancer therapy 期刊论文 Dejuan Sun;Yuqian Zhao;Shouyue Zhang;Lan Zhang;Bo Liu;Liang Ouyang
17 新型eEF2K抑制剂的制备及应用 专利 刘博;欧阳亮;张岚;姚大红;王贯
18 Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment 期刊论文 Ouyang Liang;Zhang Lan;Zhang Shouyue;Yao Dahong;Zhao Yuqian;Wang Guan;Fu Leilei;Lei Peng;Liu Bo
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