基于粒径智能调节、具有肿瘤微环境响应的脑转移瘤靶向递药系统研究

81402866
2014
H3408.药剂学
高会乐
青年科学基金项目
教授
四川大学
23万元
靶向递药系统;粒径可智能化调节;脑转移瘤;肿瘤微环境响应性
2015-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. 期刊论文 Ruan Shaobo;Cao Xi;Cun Xingli;Hu Guanlian;Zhou Yi;Zhang Yijia;Lu Libao;He Qin;Gao Huile
2 Noninvasive In Vivo Diagnosis of Brain Glioma Using RGD-Decorated Fluorescent Carbonaceous Nanospheres. 期刊论文 Ruan Shaobo;Chen Jiantao;Cun Xingli;Long Yang;Tang Jie;Qian Jun;Shen Shun;Jiang Xinguo;Zhu Jianhua;He Qin;Gao Huile
3 Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma. 期刊论文 Ruan Shaobo;He Qin;Gao Huile
4 新型药物递释系统的研究进展 期刊论文 高会乐;蒋新国
5 Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer 期刊论文 Ruan S;Zhang L;Chen J;Cao T;Yang Y;Liu Y;He Q;Gao F;Gao H
6 肿瘤靶向递药新策略的研究进展 期刊论文 高会乐;蒋新国
7 Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment. 期刊论文 Hu Guanlian;Chun Xingli;Wang Yang;He Qin;Gao Huile
8 Tumor homing cell penetrating peptide decorated nanoparticles used for enhancing tumor targeting delivery and therapy 期刊论文 Gao Huile;Zhang Qianyu;Yang Yuting;Jiang Xinguo;He Qin
9 A simple one-step synthesis of melanin-originated red shift emissive carbonaceous dots for bioimaging. 期刊论文 Hu Chuan;Liu Yongmei;Chen Jiantao;He Qin;Gao Huile
10 Non-invasive imaging of breast cancer using RGDyK functionalized fluorescent carbonaceous nanospheres 期刊论文 Ruan Shaobo;Qian Jun;Shen Shun;Chen Jiantao;Cun Xingli;Zhu Jianhua;Jiang Xinguo;He Qin;Gao Huile
11 Melanin-originated carbonaceous dots for triple negative breast cancer diagnosis by fluorescence and photoacoustic dual-mode imaging. 期刊论文 Xiao Wei;Li Yuan;Hu Chuan;Huang Yuan;He Qin;Gao Huile
12 豆荚蛋白酶响应的功能化金纳米粒用于皮下移植瘤靶向药物递送和治疗 期刊论文 阮少波;何勤;高会乐
13 Integrin-mediated active tumor targeting and tumor microenvironment response dendrimer-gelatin nanoparticles for drug delivery and tumor treatment. 期刊论文 Hu Guanlian;Zhang Huiqing;Zhang Li;Ruan Shaobo;He Qin;Gao Huile
14 Multistage drug delivery system based on microenvironment-responsive dendrimer-gelatin nanoparticles for deep tumor penetration 期刊论文 Hu Guanlian;Wang Yang;He Qin;Gao Huile
15 Normalizing Tumor Vessels To Increase the Enzyme-Induced Retention and Targeting of Gold Nanoparticle for Breast Cancer Imaging and Treatment. 期刊论文 Xiao Wei;Ruan Shaobo;Yu Wenqi;Wang Ranran;Hu Chuan;Liu Rui;Gao Huile
16 In vitro and in vivo toxicology of bare and PEGylated fluorescent carbonaceous nanodots in mice and zebrafish: the potential relationship with autophagy 期刊论文 Chen Jiantao;Sun Huaqin;Ruan Shaobo;Wang Yang;Shen Shun;Xu Wenming;He Qin;Gao Huile
17 A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan. 期刊论文 Cun Xingli;Ruan Shaobo;Chen Jiantao;Zhang Li;Li Jianping;He Qin;Gao Huile
18 Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles. 期刊论文 Hu Guanlian;Cun Xingli;Ruan Shaobo;Shi Kairong;Wang Yang;Kuang Qifang;Hu Chuan;Xiao Wei;He Qin;Gao Huile
19 Perspectives on Dual Targeting Delivery Systems for Brain Tumors. 期刊论文 Gao Huile
20 Ligand-Mediated and Enzyme-Directed Precise Targeting and Retention for the Enhanced Treatment of Glioblastoma. 期刊论文 Ruan Shaobo;Xiao Wei;Hu Chuan;Zhang Huajin;Rao Jingdong;Wang Sihan;Wang Xiao;He Qin;Gao Huile
21 Shaping Tumor Microenvironment for Improving Nanoparticle Delivery. 期刊论文 Gao Huile
22 Matrix metalloproteases-responsive nanomaterials for tumor targeting diagnosis and treatment. 期刊论文 Xiong Jingyuan;Gao Huile
23 Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy. 期刊论文 Yang Shu;Gao Huile
24 Glioma cell-targeting doxorubicin delivery and redox-responsive release using angiopep-2 decorated carbonaceous nanodots 期刊论文 Chen Jiantao;Cun Xingli;Ruan Shaobo;Wang Yang;Zhang Yanling;He Qin;Gao Huile
25 Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation. 期刊论文 Ruan Shaobo;Hu Chuan;Tang Xian;Cun Xingli;Xiao Wei;Shi Kairong;He Qin;Gao Huile
26 Polyethylene glycol modification decreases the cardiac toxicity of carbonaceous dots in mouse and zebrafish models. 期刊论文 Chen Jian-tao;Sun Hua-qin;Wang Wei-liang;Xu Wen-ming;He Qin;Shen Shun;Qian Jun;Gao Hui-le
27 A Novel Strategy through Combining iRGD Peptide with Tumor-Microenvironment-Responsive and Multistage Nanoparticles for Deep Tumor Penetration. 期刊论文 Cun Xingli;Chen Jiantao;Ruan Shaobo;Zhang Li;Wan Jingyu;He Qin;Gao Huile
28 Progress and perspectives on targeting nanoparticles for brain drug delivery. 期刊论文 Gao Huile
29 Ligand-Mediated and Enzyme-Directed Precise Targeting and Retention for the Enhanced Treatment of Glioblastoma. 期刊论文 Ruan Shaobo;Xiao Wei;Hu Chuan;Zhang Huajin;Rao Jingdong;Wang Sihan;Wang Xiao;He Qin;Gao Huile
30 Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation. 期刊论文 Ruan Shaobo;Hu Chuan;Tang Xian;Cun Xingli;Xiao Wei;Shi Kairong;He Qin;Gao Huile
31 A Novel Strategy through Combining iRGD Peptide with Tumor-Microenvironment-Responsive and Multistage Nanoparticles for Deep Tumor Penetration. 期刊论文 Cun Xingli;Chen Jiantao;Ruan Shaobo;Zhang Li;Wan Jingyu;He Qin;Gao Huile
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