IGF-1信号通路在细胞衰老与肿瘤形成过程中的作用与分子机制研究
81330054
2013
H18.肿瘤学
肖智雄
重点项目
教授
四川大学
290万元
SIRT1;前列腺肿瘤;类胰岛素生长因子-1;细胞衰老;p53
2014-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation | 期刊论文 | Tingjun Lei;Peixuan Zhang;Xudong Zhang;Xue Xiao;Jingli Zhang;Tong Qiu;Qian Dai;Yujun Zhang;Ling Min;Qian Li;Rutie Yin;Ping Ding;Ni Li;Yi Qu;Dezhi Mu;Jun Qin;Xiaofeng Zhu;Zhi-Xiong Xiao;Qintong Li |
| 2 | p53-R273H upregulates neuropilin-2 to promote cell mobility and tumor metastasis | 期刊论文 | Tao Lv;Xianqiang Wu;Lijuan Sun;Qingyong Hu;Yang Wan;Liang Wang;Zhiqiang Zhao;Xiao Tu;Zhi-Xiong Jim Xiao |
| 3 | Delta Np63 alpha activates CD82 metastasis suppressor to inhibit cancer cell invasion | 期刊论文 | Wu J.;Liang S.;Bergholz J.;He H.;Walsh E. M.;Zhang Y.;Xiao Z-X |
| 4 | MDM2/MDMX: Master negative regulators for p53 and RB | 期刊论文 | Linshan Hu;Haibo Zhang;Johann Bergholz;Shengnan Sun;Zhi-Xiong Jim Xiao |
| 5 | Delta Np63 alpha is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis | 期刊论文 | Linshan Hu;Shan Liang;Hu Chen;Tao Lv;Junfeng Wu;Deshi Chen;Min Wu;Shengnan Sun;Haibo Zhang;Han You;Hongbin Ji;Yujun Zhang;Johann Bergholz;Zhi-Xiong Jim Xiao |
| 6 | Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase | 期刊论文 | Yong Yi;Lingfeng Gao;Min Wu;Juan Ao;Chunyan Zhang;Xiaodong Wang;Min Lin;Johann Bergholz;Yujun Zhang;Zhi-Xiong Jim Xiao |
| 7 | Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ΔNp63α and Inhibits Cancer Cell Viability. | 期刊论文 | Yong Yi;Deshi Chen;Juan Ao;Shengnan Sun;Min Wu;Xiaorong Li;Johann Bergholz;Yujun Zhang;Zhi-Xiong Xiao |
| 8 | Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence | 期刊论文 | Tran D;Bergholz J;Zhang H;He H;Wang Y;Zhang Y;Li Q;Kirkland JL;Xiao ZX |
| 9 | p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation | 期刊论文 | Hanbing He;Cheng Wang;Qian Dai;Fengtian Li;Johann Bergholz;Zhonghan Li;Qintong Li;Zhi-Xiong Xiao |
| 10 | SIRT1-T177位点磷酸化在衰老相关疾病中作为生物标记物的用途 | 专利 | 肖智雄;王阳;赵志强;王亮 |
| 11 | Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation. | 期刊论文 | Dai Qian;Luan Guangxin;Deng Li;Lei Tingjun;Kang Han;Song Xu;Zhang Yujun;Xiao Zhi-Xiong;Li Qintong |
| 12 | MDMX exerts its oncogenic activity via suppression of retinoblastoma protein | 期刊论文 | Haibo Zhang;Linshan Hu;Wei Qiu;Tao Deng;Yujun Zhang;Johann Bergholz;Zhi-Xiong Xiao |
| 13 | Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage. | 期刊论文 | Tong Y;Ying H;Liu R;Li L;Bergholz J;Xiao Z-X |
| 14 | A Distinct Expression Pattern of Cyclin K in Mammalian Testes Suggests a Functional Role in Spermatogenesis. | 期刊论文 | Xiang X;Deng L;Zhang J;Zhang. X;Lei T;Luan G;Yang C;Xiao ZX;Li Q;Li Q |
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