基于抗骨质疏松新靶点TPH1的药物设计合成、结构优化与活性筛选

81102325
2011
H3401.合成药物化学
欧阳亮
青年科学基金项目
研究员
四川大学
22万元
TPH1抑制剂;五羟色胺;结构优化;抗骨质疏松
2012-01-01到2014-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives 期刊论文 Ouyang, Liang|Huang, Yuhui|Zhao, Yuwei|He, Gu|Xie, Yongmei|Liu, Jie|He, Jun|Liu, Bo|Wei, Yuquan|
2 Selective bone targeting 5-fluorouracil prodrugs: Synthesis and preliminary biological evaluation 期刊论文 He, Dongsheng|Zhang, Jing|He, Gu|Jiang, Bo|Wang, Qiang|Chen, Zhengjun|Pan, Junzhu|Li, Yanhua|Guo, Li|
3 Design, synthesis and biological evaluation of enzymatically cleavable NSAIDs prodrugs derived from self-immolative dendritic scaffolds for the treatment of inflammatory diseases 期刊论文 Wei, Jinbao|Shi, Jianyou|Zhang, Jing|He, Gu|Pan, Junzhu|He, Jun|Zhou, Rui|Guo, Li|Ouyang, Liang|
4 Molecular Dynamics Simulation of Tryptophan Hydroxylase-1: Binding Modes and Free Energy Analysis to Phenylalanine Derivative Inhibitors 期刊论文 Zhong, Hao|Huang, Wei|He, Gu|Peng, Cheng|Wu, Fengbo|Ouyang, Liang|
5 Combined Structure-Based Pharmacophore and 3D-QSAR Studies on Phenylalanine Series Compounds as TPH1 Inhibitors 期刊论文 Ouyang, Liang|He, Gu|Huang, Wei|Song, Xiangrong|Wu, Fengbo|Xiang, Mingli|
6 Synthesis of novel spirooxindolo-pyrrolidines, pyrrolizidines, and pyrrolothiazoles via a regioselective three-component [3+2] cycloaddition and their preliminary antimicrobial evaluation 期刊论文 Wu, Guansheng|Ouyang, Liang|Liu, Jie|Zeng, Shi|Huang, Wei|Han, Bo|Wu, Fengbo|He, Gu|Xiang, Mingli|
7 A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction 期刊论文 He, Jun|Ouyang, Guang|Yuan, Zhixiang|Tong, Rongsheng|Shi, Jianyou|Ouyang, Liang|
8 Organocatalytic Diastereoselective Multicomponent Domino Knoevenagel/Diels-Alder Reaction: Synthesis of Densely Functionalized Spiro[5.5]undecane 期刊论文 Liu, Pan|Chen, Duoyuan|Zhang, Shouyue|Zhou, Rui|Ren, Wen|Ouyang, Liang|He, Gu|
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