【81172632】Nrf2-AREs和NF-κB信号通路及其交互作用在低水平砷诱导细胞凋亡中的作用国家自然基金项目

Nrf2-AREs和NF-κB信号通路及其交互作用在低水平砷诱导细胞凋亡中的作用

项目批准号： 81172632

批准年份： 2011

学科分类： H3001.环境卫生

项目负责人：张遵真

资助类别：面上项目

负责人职称：教授

依托单位：四川大学

资助金额： 70万元

关键词： Nrf2;谷胱甘肽;NF-κB;细胞凋亡;砷

起止时间： 2012-01-01到2015-12-31

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序号	标题	类型	作者
1	Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich’s Ataxia	期刊论文	Shyama Ramjagsingh\|Irina U. Agoulnik\|Yuan Liu\|zunzhen Zhang\|
2	Resveratrol ProtectsAgainst Arsenic Trioxide-Induced Oxidative Damage Through Maintenance ofGlutathione Homeostasis and Inhibition of Apoptotic progression	期刊论文	Jiang Xuejun\|Lai Yanhao\|Liu Yuan\|Zhang Zunzhen\|
3	DNA 聚合酶β表达水平对苯代谢物氢醌致细胞凋亡及线粒体膜电位的影响	期刊论文	杨沫\|张遵真\|吴媚\|邓雯文\|
4	Instability of CTG Repeats Is Governed by the Position of a DNA Base Lesion through Base Excision Repair	期刊论文	Lai, Yanhao\|Xu, Meng\|Zhang, Zunzhen\|Liu, Yuan\|
5	外源性还原型谷胱甘肽对亚砷酸钠诱导遗传毒性及氧化应激的保护作用	期刊论文	陈承志\|蒋学君\|张遵真\|
6	凋亡诱导因子AIF基因真核表达载体的构建及表达	期刊论文	邓雯文\|刘蜀坤\|张遵真\|
7	Critical role of cellular glutathione homeostasis for trivalentinorganic arsenite-induced oxidative damage in human bronchial epithelial cells	期刊论文	Chengzhi Chen\|Yuan Liu\|Ping Zhang\|zunzhen Zhang\|
8	A systematic assessment ofgenotoxicity on pivaloylacylation-7ADCA-a wide existing antibiotic impurity	期刊论文	Qingying Luo\|Yang Li\|Zunzhen Zhang\|
9	亚砷酸钠和三氧化二砷对人正常肝细胞增殖与凋亡效应的影响	期刊论文	赵巍\|陈承志\|蒋学君\|张遵真\|
10	三氧化二砷诱导肿瘤细胞死亡的分子机制研究进展	期刊论文	罗擎英\|李洋\|张遵真\|
11	砷剂在肿瘤治疗中的现代应用	期刊论文	李洋\|罗擎英\|张遵真\|
12	Sodium arsenite and arsenic trioxide differently affect the oxidative stress, genotoxicity and apoptosis in A549 cells: An implication for the paradoxical mechanism	期刊论文	Jiang, Xuejun\|Chen, Chengzhi\|Zhao, Wei\|Zhang, Zunzhen\|
13	Sodium arsenite and arsenic trioxide differently affect the oxidative stress, genotoxicity and apoptosis in A549 cells: An implication for the paradoxical mechanism	期刊论文	Xuejun Jiang\|Chengzhi Chen\|Wei Zhao\|zunzhenZhang\|
14	Dual role of resveratrol in modulation of genotoxicity induced by sodium arsenite via oxidative stress and apoptosis	期刊论文	Chen, Chengzhi\|Jiang, Xuejun\|Zhao, Wei\|Zhang, ZunZhen\|
15	PARP-1 抑制剂4-氨基-1，8-萘二胺增加阿霉素对小鼠胚胎成纤维细胞敏感性的研究	期刊论文	邓雯文\|赵巍\|吴媚\|张遵真\|
16	亚砷酸钠和三氧化二砷对人正常肝细胞增殖与凋亡效应的影响	期刊论文	赵巍\|陈承志\|蒋学君\|张遵真\|
17	Deregulated expression of DNA polymerase β is involved in the progression of genomic instability	期刊论文	Shukun Liu\|Mei Wu\|Yuan Liu\|Zunzhen Zhang\|
18	油菜秸杆外壳对水溶液中六价铬的吸附作用	期刊论文	刘新\|冷言冰\|谷仕艳\|张遵真\|
19	抗生素杂质头孢呋辛内酯的遗传毒性研究	期刊论文	赵巍\|康晓熙\|邓雯文\|张遵真\|
20	Resveratrol Synergistically Triggers Apoptotic Cell Death with Arsenic Trioxide via Oxidative Stress in Human Lung Adenocarcinoma A549 Cells	期刊论文	Shiyan Gu\|Chengzhi Chen\|Xuejun Jiang\|zunzhen Zhang\|
21	Resveratrol Protects Against Arsenic Trioxide-Induced Oxidative Damage Through Maintenance of Glutathione Homeostasis and Inhibition of Apoptotic progression	期刊论文	Xuejun Jiang\|Yanhao Lai\|Yuan Liu\|zunzhen Zhang\|
22	Arsenic Trioxide Co-exposure Potentiates Benzo(a)pyrene Genotoxicity by Enhancing the Oxidative Stress in Human Lung Adenocarcinoma Cell	期刊论文	Chengzhi Chen\|Xuejun Jiang\|Ren Yaou\|Zhangzunzhen\|
23	三氧化二砷诱导肝癌细胞凋亡的机制研究	期刊论文	胡亚男\|蒋学君\|陈承志\|张遵真\|
24	Involvement of DNA polymerase beta overexpression in the malignant transformation induced by benzo[a]pyrene	期刊论文	Lai, Yanhao\|Deng, Wenwen\|Liu, Yuan\|Zhang, Zunzhen\|
25	DNA polymerase beta is involved in the protection against the cytotoxicity and genotoxicity of cigarette smoke.	期刊论文	Xin Xu\|Mo Yang\|Yaou Ren\|Zunzhen Zhang\|
26	Dual role of resveratrol in modulation of genotoxicity induced by sodium arsenite via oxidative stress and apoptosis	期刊论文	Chengzhi Chen\|Xuejun Jiang\|Wei Zhao\|zunzhen zhang\|
27	The Protective Role of Resveratrol in the Sodium Arsenite-Induced Oxidative Damage via Modulation of Intracellular GSH Homeostasis	期刊论文	Chengzhi Chen\|Xuejun Jiang\|Yanan Hu\|zunzhenZhang\|
28	4-氨基-1,8-萘二胺对三氧化二砷在肝癌细胞中的增敏作用研究	期刊论文	李洋\|罗擎英\|邓建军\|张遵真\|
29	苯并[a]芘诱导的恶性转化细胞中DNA聚合酶β高表达的机制研究	期刊论文	赵巍\|吴媚\|杨沫\|张遵真\|
30	三氧化二砷诱导肿瘤细胞死亡的分子机制研究进展	期刊论文	罗擎英\|李洋\|张遵真\|

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