高盐和应激致室旁核神经激素兴奋引发血管功能异常和高血压的机制
91439120
2014
H0213.血压调节异常与高血压病
康玉明
重大研究计划
教授
西安交通大学
80万元
血管稳态与重构;炎症;应激;下丘脑室旁核;高血压
2015-01-01到2017-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Relaxin in Paraventricular Nucleus Contributes to Sympathetic Overdrive and Hypertension via PI3K-Akt Pathway | 期刊论文 | Hai-Jian Sun;Dan Chen;Ying Han;Ye-Bo Zhou;Jue-Jin Wang;Qi Chen;Yue-Hua Li;Xing-Ya Gao;Yu-Ming Kang;Guo-Qing Zhu |
| 2 | Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress | 期刊论文 | Xiao-Jing Yu;Dong-Mei Zhang;Lin-Lin Jia;Jie Qi;Xin-Ai Song;Hong Tan;Wei Cui;Wensheng Chen;Guo-Qing Zhu;Da-Nian Qin;Yu-Ming Kang |
| 3 | Endogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates neurohormonal excitation in high salt-induced hypertension | 期刊论文 | Meng Zhang;Da-Nian Qin;Yu-Ping Suo;Qing Su;Hong-Bao Li;Yu-Wang Miao;Jing Guo;Zhi-Peng Feng;Jie Qi;Hong-Li Gao;Jian-Jun Mu;Guo-Qing Zhu;Yu-Ming Kang |
| 4 | Blockade of Salusin-beta in Hypothalamic Paraventricular Nucleus Attenuates Hypertension and Cardiac Hypertrophy in Salt-induced Hypertensive Rats | 期刊论文 | Hong-Bao Li;Da-Nian Qin;Yu-Ping Suo;Jing Guo;Qing Su;Yu-Wang Miao;Wen-Yan Sun;Qiu-Yue Yi;Wei Cui;Kang Cheng;Guo-Qing Zhu;Yu-Ming Kang |
| 5 | Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy | 期刊论文 | Ming-Xia Zhao;Bing Zhou;Li Ling;Xiao-Qing Xiong;Feng Zhang;Qi Chen;Yue-Hua Li;Yu-Ming Kang;Guo-Qing Zhu |
| 6 | GABA in Paraventricular Nucleus Regulates Adipose Afferent Reflex in Rats | 期刊论文 | Lei Ding;Run Gao;Xiao-Qing Xiong;Xing-Ya Gao;Qi Chen;Yue-Hua Li;Yu-Ming Kang;Guo-Qing Zhu |
| 7 | Silencing salusin-β attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats | 期刊论文 | Xing-Sheng Ren;Li Ling;Bing Zhou;Ying Han;Ye-Bo Zhou;Qi Chen;Yue-Hua Li;Yu-Ming Kang;Guo-Qing Zhu |
| 8 | Renin-angiotensin system acting on reactive oxygen species in paraventricular nucleus induces sympathetic activation via AT1R/PKC gamma/Rac1 pathway in salt-induced hypertension | 期刊论文 | Qing Su;Chan-Juan Huo;Hong-Bao Li;Kai-Li Liu;Xiang Li;Qing Yang;Xin-Ai Song;Wen-Sheng Chen;Wei Cui;Guo-Qing Zhu;Xiao-Lian Shi;Jin-Jun Liu;Yu-Ming Kang |
| 9 | 下丘脑室旁核氧化应激在心血管疾病中作用机制的研究 | 奖励 | 康玉明;曹永孝;刘进军;雷霆;孙强;赵秀芳;齐杰;于晓静;宋新爱 |
| 10 | Central blockade of salusin beta attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats | 期刊论文 | Hong-Bao Li;Da-Nian Qin;Kang Cheng;Qing Su;Yu-Wang Miao;Jing Guo;Meng Zhang;Guo-Qing Zhu;Yu-Ming Kang |
| 11 | β-aminoisobutyric Acid Attenuates Hepatic Endoplasmic Reticulum Stress and Glucose/Lipid Metabolic Disturbance in Mice with Type 2 Diabetes | 期刊论文 | Chang-Xiang Shi;Ming-Xia Zhao;Xiao-Dong Shu;Xiao-Qing Xiong;Jue-Jin Wang;Xing-Ya Gao;Qi Chen;Yue-Hua Li;Yu-Ming Kang;Guo-Qing Zhu |
| 12 | NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension | 期刊论文 | Hai-Jian Sun;Xing-Sheng Ren;Xiao-Qing Xiong;Yun-Zhi Chen;Ming-Xia Zhao;Jue-Jin Wang;Ye-Bo Zhou;Ying Han;Qi Chen;Yue-Hua Li;Yu-Ming Kang;Guo-Qing Zhu |
| 13 | PVN Blockade of p44/42 MAPK Pathway Attenuates Salt-induced Hypertension through Modulating Neurotransmitters and Attenuating Oxidative Stress | 期刊论文 | Hong-Li Gao;Xiao-Jing Yu;Kai-Li Liu;Xiao-Lian Shi;Jie Qi;Yan-Mei Chen;Yan Zhang;Juan Bai;Qiu-Yue Yi;Zhi-Peng Feng;Wen-Sheng Chen;Wei Cui;Jin-Jun Liu;Guo-Qing Zhu;Yu-Ming Kang |
| 14 | Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats | 期刊论文 | Juan Bai;Xiao-Jing Yu;Kai-Li Liu;Fang-Fang Wang;Gui-Xia Jing;Hong-Bao Li;Yan Zhang;Chan-Juan Huo;Xiang Li;Hong-Li Gao;Jie Qi;Yu-Ming Kang |
| 15 | FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice. | 期刊论文 | Tong-Yan Liu;Xiao-Qing Xiong;Xing-Sheng Ren;Ming-Xia Zhao;Chang-Xiang Shi;Jue-Jin Wang;Ye-Bo Zhou;Feng Zhang;Ying Han;Xing-Ya Gao;Qi Chen;Yue-Hua Li;Yu-Ming Kang;Guo-Qing Zhu |
| 16 | Reduced lipolysis response to adipose afferent reflex involved in impaired activation of adrenoceptor-cAMP-PKA-hormone sensitive lipase pathway in obesity. | 期刊论文 | Lei Ding;Feng Zhang;Ming-Xia Zhao;Xing-Sheng Ren;Qi Chen;Yue-Hua Li;Yu-Ming Kang;Guo-Qing Zhu |
| 17 | Salusin β within the Nucleus Tractus Solitarii Suppresses Blood Pressure via Inhibiting the Activities of Presympathetic Neurons in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats | 期刊论文 | Hong-Bao Li;Yan Lu;Jin-Jun Liu;Yu-Wang Miao;Tian-Zhen Zheng;Qing Su;Jie Qi;Hong Tan;Zu-Yi Yuan;Guo-Qing Zhu;Yu-Ming Kang |
| 18 | Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus. | 期刊论文 | Yan Zhang;Xiao-Jing Yu;Wen-Sheng Chen;Hong-Li Gao;Kai-Li Liu;Xiao-Lian Shi;Xiao-Yan Fan;Lin-Lin Jia;Wei Cui;Guo-Qing Zhu;Jin-Jun Liu;Yu-Ming Kang |
| 19 | Alpha lipoic acid supplementation attenuates reactive oxygen species in hypothalamic paraventricular nucleus and sympathoexcitation in high salt-induced hypertension. | 期刊论文 | Qing Su;Jin-Jun Liu;Wei Cui;Xiao-Lian Shi;Jing Guo;Hong-Bao Li;Chan-Juan Huo;Yu-Wang Miao;Meng Zhang;Qing Yang;Yu-Ming Kang |
| 20 | Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes | 期刊论文 | Tong-Yan Liu;Chang-Xiang Shi;Run Gao;Hai-Jian Sun;Xiao-Qing Xiong;Lei Ding;Qi Chen;Yue-Hua Li;Jue-Jin Wang;Yu-Ming Kang;Guo-Qing Zhu |
| 21 | FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity | 期刊论文 | Xiao-Qing Xiong;Dan Chen;Hai-Jian Sun;Lei Ding;Jue-Jin Wang;Qi Chen;Yue-Hua Li;Ye-Bo Zhou;Ying Han;Feng Zhang;Xing-Ya Gao;Yu-Ming Kang;Guo-Qing Zhu |
| 22 | Chronic infusion of epigallocatechin-3-O-gallate into the hypothalamic paraventricular nucleus attenuates hypertension and sympathoexcitation by restoring neurotransmitters and cytokines. | 期刊论文 | Qiu-Yue Yi;Hong-Bao Li;Jie Qi;Xiao-Jing Yu;Chan-Juan Huo;Xiang Li;Juan Bai;Hong-Li Gao;Bo Kou;Kai-Li Liu;Dong-Dong Zhang;Wen-Sheng Chen;Wei Cui;Guo-Qing Zhu;Xiao-Lian Shi;Yu-Ming Kang |
| 23 | Oral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus. | 期刊论文 | Hong-Li Gao;Xiao-Jing Yu;Jie Qi;Qiu-Yue Yi;Wang-Hui Jing;Wen-Yan Sun;Wei Cui;Jian-Jun Mu;Zu-Yi Yuan;Xiu-Fang Zhao;Kai-Li Liu;Guo-Qing Zhu;Xiao-Lian Shi;Jin-Jun Liu;Yu-Ming Kang |
| 24 | Targeting Interleukin-1 Betato Suppress Sympathoexcitation in Hypothalamic Paraventricular Nucleus in Dahl Salt-Sensitive Hypertensive Rats | 期刊论文 | Jie Qi;Xiu-Fang Zhao;Xiao-Jing Yu;Qiu-Yue Yi;Xiao-Lian Shi;Hong Tan;Xiao-Yan Fan;Hong-Li Gao;Li-Ying Yue;Zhi-Peng Feng;Yu-Ming Kang |
| 25 | NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1. | 期刊论文 | Jie Qi;Xiao-Jing Yu;Xiao-Lian Shi;Hong-Li Gao;Qiu-Yue Yi;Hong Tan;Xiao-Yan Fan;Yan Zhang;Xin-Ai Song;Wei Cui;Jin-Jun Liu;Yu-Ming Kang |
| 26 | TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension | 期刊论文 | Hong-Bao Li;Xiang Li;Chan-Juan Huo;Qing Su;Jing Guo;Zu-Yi Yuan;Guo-Qing Zhu;Xiao-Lian Shi;Jin-Jun Liu;Yu-Ming Kang |
| 27 | Salusin-β Promotes Vascular Smooth Muscle Cell Migration and Intimal Hyperplasia after Vascular Injury via ROS/NFκB/MMP-9 Pathway | 期刊论文 | Hai-Jian Sun;Ming-Xia Zhao;Xing-Sheng Ren;Tong-Yan Liu;Qi Chen;Yue-Hua Li;Yu-Ming Kang;Jue-Jin Wang;Guo-Qing Zhu |
| 28 | Paraventricular Nucleus Infusion of Epigallocatechin-3-O-Gallate Improves Renovascular Hypertension | 期刊论文 | Qiu-Yue Yi;Jie Qi;Xiao-Jing Yu;Hong-Bao Li;Yan Zhang;Qing Su;Tao Shi;Dong-Mei Zhang;Jing Guo;Zhi-Peng Feng;Mo-Lin Wang;Guo-Qing Zhu;Jin-Jun Liu;Xiao-Lian Shi;Yu-Ming Kang |
| 29 | Tert-butylhydroquinone attenuates oxidative stress and inflammation in hypothalamic paraventricular nucleus in high salt-induced hypertension | 期刊论文 | Juan Bai;Xiao-Jing Yu;Kai-Li Liu;Fang-Fang Wang;Hong-Bao Li;Xiao-Lian Shi;Yan Zhang;Chan-Juan Huo;Xiang Li;Hong-Li Gao;Jie Qi;Jin-Jun Liu;Guo-Qing Zhu;Wen-Sheng Chen;Wei Cui;Yu-Ming Kang |
| 30 | BCL6 attenuates renal inflammation via negativeregulation of NLRP3 transcription | 期刊论文 | Dan Chen;Xiao-Qing Xiong;Ying-Hao Zang;Ying Tong;Bing Zhou;Qi Chen;Yue-Hua Li;Xing-Ya Gao;Yu-Ming Kang;Guo-Qing Zhu |
| 31 | Salusin-β induces foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFκBpathway | 期刊论文 | Hai-Jian Sun;Ming-Xia Zhao;Tong-Yan Liu;Xing-Sheng Ren;Qi Chen;Yue-Hua Li;Yu-Ming Kang;Guo-Qing Zhu |
| 32 | Hydrogen sulfide in paraventricular nucleus attenuates blood pressure by regulating oxidative stress and inflammatory cytokines in high salt-induced hypertension | 期刊论文 | Yan-Feng Liang;Dong-Dong Zhang;Xiao-Jing Yu;Hong-Li Gao;Kai-Li Liu;Jie Qi;Hong-Bao Li;Qiu-Yue Yi;Wen-Sheng Chen;Wei Cui;Guo-Qing Zhu;Yu-Ming Kang |
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