【81001357】新骨架结构的CXCR4和FAK双靶点抑制剂的设计、合成和抗肿瘤活性研究国家自然基金项目

新骨架结构的CXCR4和FAK双靶点抑制剂的设计、合成和抗肿瘤活性研究

项目批准号： 81001357

批准年份： 2010

学科分类： H3401.合成药物化学

项目负责人：何谷

资助类别：青年科学基金项目

负责人职称：研究员

依托单位：四川大学

资助金额： 17万元

关键词：趋化因子受体;抗肿瘤;双靶点抑制剂;粘着斑激酶

起止时间： 2011-01-01到2013-12-31

中英文摘要
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序号	标题	类型	作者
1	Discovery of Novel Focal Adhesion Kinase Inhibitors Using a Hybrid Protocol of Virtual Screening Approach Based on Multicomplex-Based Pharmacophore and Molecular Docking	期刊论文	Wu Fengbo\|Xu Ting\|He Gu\|Ouyang Liang\|Han Bo\|Peng Cheng\|Song Xiangrong\|Xiang Mingli\|
2	Asymmetric synthesis of a structurally and stereochemically complex spirooxindole pyran scaffold through an organocatalytic multicomponent cascade reaction	期刊论文	Xie, Xin\|Peng, Cheng\|He, Gu\|Leng, Hai-Jun\|Wang, Biao\|Huang, Wei\|Han, Bo\|
3	Development of a novel biocompatible poly(ethylene glycol)-block-poly(gamma-cholesterol-l-glutamate) as hydrophobic drug carrier	期刊论文	He, Gu\|Li, Bo\|Yu, Yiyi\|Zhang, Ying\|Wu, Yang\|Ren, Wen\|Zheng, Yu\|He, Jun\|Xie, Yongmei\|
4	Novel Hybrid Virtual Screening Protocol Based on Molecular Docking and Structure-Based Pharmacophore for Discovery of Methionyl-tRNA Synthetase Inhibitors as Antibacterial Agents	期刊论文	Liu, Chi\|He, Gu\|Jiang, Qinglin\|Han, Bo\|Peng, Cheng\|
5	Synthesis, Characterization and In Vitro Evaluation of Self-Assembled poly(ethylene glycol)-glycyrrhetinic Acid Conjugates	期刊论文	Gu He\|Zhiyao He\|Xi Zheng\|Junmin Li\|Chi Liu\|Xiangrong Song\|Liang Ouyang\|Fengbo Wu\|
6	Analysis of furo[3,2-c]tetrahydroquinoline and pyrano[3,2-c]tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry	期刊论文	Li, Rui\|Luo, Hao\|Zhong, Hao\|Wu, Feng\|Zhou, Meng\|Zhang, Wenjuan\|Han, Xuan\|Yan, Guoyi\|Zhang, Mengqi\|
7	Synthesis and characterization of a novel methoxy poly(ethylene glycol)-Tat peptide-chitosan copolymers	期刊论文	Li, Bo\|Ma, Qing\|He, Gu\|Song, Xiangrong\|Wu, Fengbo\|Zheng, Yu\|Zeng, Shi\|Liu, Chi\|Ren, Wen\|
8	Preparation, antibacterial evaluation and preliminary structure–activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives	期刊论文	Ouyang Liang\|Huang Yuhui\|Zhao Yuwei\|He Gu\|Xie Yongmei\|Liu Jie\|He Jun\|Liu Bo\|Wei Yuquan\|
9	Multicomplex-Based Pharmacophore-Guided 3D-QSAR Studies of N-Substituted 2'-(Aminoaryl)Benzothiazoles as Aurora-A Inhibitors	期刊论文	He, Gu\|Qiu, Minghua\|Li, Rui\|Ouyang, Liang\|Wu, Fengbo\|Song, Xiangrong\|Cheng, Li\|Xiang, Mingli\|Yu, Luoting\|
10	芳基磺酰胺类丙酮酸激酶M2激动剂的基于多复合物的药效团模型和定量构效关系	期刊论文	陈正军\|蒋庆琳\|何谷\|韩波\|郭丽\|
11	Biocompatible poly(ethylene glycol)-poly(γ-cholesterol-L-glutamate) copolymers: Synthesis, characterization, and in vitro studies	期刊论文	Yang Wu\|Qing Ma\|Xiangrong Song\|Yu Zheng\|Wen Ren\|Jinkun Zhang\|Liang Ouyang\|Fengbo Wu\|Gu He\|
12	Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold	期刊论文	Han, Bo\|Yang, Lei\|Peng, Cheng\|Xie, Xin\|Leng, Hai-Jun\|Wang, Biao\|Tang, Zheng-Wei\|He, Gu\|Ouyang, Liang\|
13	螺环吲哚类MDM2抑制剂的分子对接、定量构效关系和分子动力学模拟	期刊论文	李博\|周锐\|何谷\|郭丽\|黄维\|
14	Molecular Dynamics Simulation of Tryptophan Hydroxylase-1: Binding Modes and Free Energy Analysis to Phenylalanine Derivative Inhibitors	期刊论文	Zhong, Hao\|Huang, Wei\|He, Gu\|Peng, Cheng\|Wu, Fengbo\|Ouyang, Liang\|
15	Combined Structure-Based Pharmacophore and 3D-QSAR Studies on Phenylalanine Series Compounds as TPH1 Inhibitors	期刊论文	Ouyang Liang\|He Gu\|Huang Wei\|Song Xiangrong\|Wu Fengbo\|Xiang Mingli\|
16	Combined structure-based pharmacophore, virtual screening, and 3D-QSAR studies of structural diverse dehydrosqualene synthase inhibitors	期刊论文	He, Gu\|Peng, Aihua\|Luo, Youfu\|Huang, Wei\|Han, Bo\|Yang, Xiaoyan\|Ang, Wei\|Yang, Tao\|Xiang, Mingli\|
17	SYNTHESIS OF CISOR TRANS4-HETEROAROMATIC SUBSTITUTED FURANO AND PYRANO[3,2-c]TETRAHYDROQUINOLINES BY ONE-POT IMINO DIELS-ALDER REACTIONS	期刊论文	何谷\|黄维\|任闻\|郭丽\|曾实\|刘攀\|欧阳亮\|宋相容\|彭成\|
18	Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids	期刊论文	周锐\|郭丽\|彭成\|何谷\|欧阳亮\|黄维\|
19	Synthesis of novel spirooxindolo-pyrrolidines, pyrrolizidines, and pyrrolothiazoles via a regioselective three-component [3+2] cycloaddition and their preliminary antimicrobial evaluation	期刊论文	Wu, Guansheng\|Ouyang, Liang\|Liu, Jie\|Zeng, Shi\|Huang, Wei\|Han, Bo\|Wu, Fengbo\|He, Gu\|Xiang, Mingli\|
20	Synthesis, Characterization, and Evaluation of a Novel Amphiphilic Polymer RGD-PEG-Chol for Target Drug Delivery System	期刊论文	曾实\|吴逢波\|李博\|宋相容\|郑瑀\|何谷\|彭成\|黄维\|
21	Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug	期刊论文	吴逢波\|徐铤\|刘驰\|陈灿\|宋相容\|郑瑀\|何谷\|

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