感光细胞特异性表达基因NDRG2协同雌激素阻断MNU诱导视网膜色素变性的分子机制研究

81870676
2018
H1305.视网膜、脉络膜及玻璃体相关疾病
俞小瑞
面上项目
教授
西安交通大学
57万元
MNU;感光细胞;视网膜色素变性;雌激素;NDRG2
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 17β-Oestradiol Attenuates the Photoreceptor Apoptosis in Mice with Retinitis Pigmentosa by Regulating N-myc Downstream Regulated Gene 2 Expression 期刊论文 Ye-Cheng Xiong;Tao Chen;Xiao-Bei Yang;Chun-Lei Deng;Qi-Lan Ning;Rui Quan;Xiao-Rui Yu(通讯作者)
2 Bone progeria diminished the therapeutic effects of bone marrow mesenchymal stem cells on retinal degeneration 期刊论文 Chun-Lei Deng;Cheng-Biao Hu;Bao-Ying Wang;Ye-Cheng Xiong;Tao Chen;Na Zhao;Li-Hui Bao;Rui Quan;Fang-Ying Du;Bing-Dong Sui;Xiao- Rui Yu(通讯作者)
3 βE2上调Nrf2通路抵抗光诱导大鼠视网膜功能损伤 期刊论文 杜芳英;朱春晖;邓春雷;陈涛;熊业城;胡成虎;俞小瑞(通讯作者)
4 17β-雌二醇对N-甲基-N-亚硝脲诱导大鼠视网膜损伤的保护效应 期刊论文 朱春晖;朱若晨;熊业城;陈 涛;俞小瑞(通讯作者)
5 雌激素拮抗MNU诱导661W细胞凋亡机制的研究 会议论文 权蕊;熊业城;邓春雷;胡成虎;俞小瑞(通讯作者)
6 NDRG2 suppression as a molecular hallmark of photoreceptor-specific cell death in the mouse retina 期刊论文 Cheng-Biao Hu;Bing-Dong Sui;Bao-Ying Wang;Gao Li;Cheng-Hu Hu;Chen-Xi Zheng;Fang-Ying Du;Chun-Hui Zhu;Hong-Bo Li;Yan Feng;Yan Jin;Xiao-Rui Yu(通讯作者)
7 17β-Estradiol Attenuates Apoptosis of Photoreceptor Cells in Retinitis Pigmentosa Model by Regulating NDRG2 Expression 会议论文 Xiong Yecheng;Chen Tao;Deng Chunlei;Yu Xiaorui(通讯作者)
8 P-STAT3 mediates NDRG2 to regulate TIMP3 and resists photoreceptor apoptosis in RP model induced by MNU 会议论文 Tao Chen;Ye-cheng Xiong;Chun-lei Deng;Xiao-rui Yu(通讯作者)
9 Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration 期刊论文 Chun-Lei Deng;Cheng-Biao Hu;Sheng-Tao Ling;Na Zhao;Li-Hui Bao;Feng Zhou;Ye-Cheng Xiong;Tao Chen;Bing-Dong Sui;Xiao-Rui Yu(通讯作者);Cheng-Hu Hu
10 Intravitreous Delivery of Exosomes from Bone Mesenchymal Stem Cells Ameliorates N-Methyl-N-Nitrosourea Induced Photoreceptor Degeneration in Mice 会议论文 Deng chunlei;Hu Chenghu;Xiong Yecheng;Quan Rui;Chen Tao;Zhu Chunhui;Yang Xiaobei;Wang Baoying;Du Fangying;Yu Xiaorui(通讯作者)
11 NDRG2通过调控TIMP3发挥抵抗MNU诱导视网膜色素变性感光细胞凋亡的作用 会议论文 陈涛;熊业城;邓春雷;俞小瑞(通讯作者)
12 Exosomes from BMSC Ameliorates N-Methyl-N-Nitrosourea Induced Retinitis Pigmentosa 会议论文 Chun-Lei Deng;Cheng-Hu Hu;Ye-Cheng Xiong;Tao Chen;Xiao-Rui Yu(通讯作者)
13 Molecular mechanism of NDRG2 resistance to MNU-induced apoptosis of photoreceptors in retinitis pigmentosa 会议论文 Tao Chen;Ye-Cheng Xiong;Chun-Lei Deng;Xiao-rui Yu(通讯作者)
14 NDRG2在中枢神经系统疾病中的作用 期刊论文 陈 涛;熊业城;邓春雷;宁启兰;李孟星;俞小瑞(通讯作者)
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