利用CRISPR技术构建显性遗传的色素性视网膜炎模型和修复致病突变的研究
31901047
2019
C2104.共性生物技术
胥春龙
青年科学基金项目
副研究员
中国科学院脑科学与智能技术卓越创新中心
23万元
定点修复;基因敲入;基因治疗;基因编辑;常染色体显性遗传性色素性视网膜炎
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos | 期刊论文 | Yinghui Wei;Zhifang Li;Kui Xu;Hu Feng;Long Xie;Di Li;Zhenrui Zuo;Meiling Zhang;Chunlong Xu;Hui Yang;Erwei Zuo |
| 2 | Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor | 期刊论文 | Qingquan Xiao;Zhijiao Xu;Yuanyuan Xue;Chunlong Xu;Chunlong Xu;Lei Han;Yuanhua Liu;Fang Wang;Runze Zhang;Shuang Han;Xing Wang;Geng-Lin Li;Huawei Li;Hui Yang;Yilai Shu |
| 3 | Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes | 期刊论文 | Chunlong Xu;Yingsi Zhou;Qingquan Xiao;Bingbing He;Guannan Geng;Zikang Wang;Birong Cao;Xue Dong;Weiya Bai;Yifan Wang;Xiang Wang;Dongming Zhou;Tanglong Yuan;Xiaona Huo;Jinsheng Lai;Hui Yang |
| 4 | Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE | 期刊论文 | Yinghui Wei;Chunlong Xu;Hu Feng;Kui Xu;Zhifang Li;Jing Hu;Ling Zhou;YuWei;Zhenrui Zuo;Erwei Zuo;Wen Li;Hui Yang;Meiling Zhang |
| 5 | High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects | 期刊论文 | Huawei Tong;Jia Huang;Qingquan Xiao;Bingbing He;Xue Dong;Yuanhua Liu;Xiali Yang;Dingyi Han;Zikang Wang;Xuchen Wang;Wenqin Ying;Runze Zhang;Yu Wei;Chunlong Xu;Yingsi Zhou;Yanfei Li;Minqing Cai;Qifang Wang;Mingxing Xue;Guoling Li;Kailun Fang;Hainan Zhang;Hui Yang |
| 6 | Mini-dCas13X–mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy | 期刊论文 | Guoling Li;Ming Jin;Zhifang Li;Qingquan Xiao;Jiajia Lin;Dong Yang;Yuanhua Liu;Xing Wang;Long Xie;Wenqin Ying;Haoqiang Wang;Erwei Zuo;Linyu Shi;Ning Wang;Wanjin Chen;Chunlong Xu;Chunlong Xu;Hui Yang |
| 7 | Develop an efficient and specific AAV-based labeling system for Muller glia in mice | 期刊论文 | Yanxia Gao;Kailun Fang;Zixiang Yan;Haiwei Zhang;Guannan Geng;Weiwei Wu;Ding Xu;Heng Zhang;Na Zhong;Qifang Wang;Minqing Cai;Erwei Zuo;Hui Yang |
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