MLL家族蛋白调控p53甲基化的分子机制
31900934
2019
C0505.蛋白质、多肽与酶生物化学
黎彦璟
青年科学基金项目
研究员
中国科学院分子细胞科学卓越创新中心
24万元
甲基转移酶;MLL家族蛋白;赖氨酸甲基化;p53
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes | 期刊论文 | Yongxin Zheng;Yinping Huang;Jun Mencius;Yanjing Li;Lijie Zhao;Wanting Luo;Yong Chen;Shu Quan |
| 2 | The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications | 期刊论文 | Yanjing Li;Kexue Ge;Tingting Li;Cai Run;Yong Chen |
| 3 | Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases | 期刊论文 | Yanjing Li;Lijie Zhao;Xiaoxu Tian;Chao Peng;Fan Gong;Yong Chen |
| 4 | Structural basis for product specificities of MLL family methyltransferases | 期刊论文 | Yanjing Li;Lijie Zhao;Yuebin Zhang;Ping Wu;Ying Xu;Jun Mencius;Yongxin Zheng;Xiaoman Wang;Wancheng Xu;Naizhe Huang;Xianwen Ye;Ming Lei;Pan Shi;Changlin Tian;Chao Peng;Guohui Li;Zhijun Liu;Shu Quan;Yong Chen |
| 5 | DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates | 期刊论文 | Lijie Zhao;Naizhe Huang;Jun Mencius;Yanjing Li;Ying Xu;Yongxin Zheng;Wei He;Na Li;Jun Zheng;Min Zhuang;Shu Quan;Yong Chen |
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