胆固醇代谢必需膜蛋白固醇Δ8, Δ7异构酶的结构与功能
31870726
2018
C0501.结构生物学
李典范
面上项目
研究员
中国科学院分子细胞科学卓越创新中心
65万元
脂质代谢;脂立方相;酶;膜蛋白;胆固醇代谢
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Thermostabilization of membrane proteins by consensus mutation: a case study for a fungal Δ8-7 sterol isomerase | 期刊论文 | Hebang Yao;Hongmin Cai;Dianfan Li |
| 2 | Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants | 期刊论文 | Tingting Li;Bingjie Zhou;Zhipu Luo;Yanling Lai;Suqiong Huang;Yuanze Zhou;Yaning Li;Anupriya Gautam;Salome Bourgeau;Shurui Wang;Juan Bao;Jingquan Tan;Dimitri Lavillette;Dianfan L |
| 3 | A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2 | 期刊论文 | Hebang Yao;Hongmin Cai;Tingting Li;Bingjie Zhou;Wenming Qin;Dimitri Lavillette;Dianfan Li |
| 4 | Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody | 期刊论文 | Tingting Li;Hongmin Cai;Yapei Zhao;Yanfang Li;Yanling Lai;Hebang Yao;Liu Daisy Liu;Zhou Sun;Martje Fentener van Vlissingen;Thijs Kuiken;Corine H GeurtsvanKessel;Ning Zhang;Bingjie Zhou;Lu Lu;Yuhuan Gong;Wenming Qin;Moumita Mondal;Bowen Duan;Shiqi Xu;Audrey S Richard;Hervé Raoul;JianFeng Chen;Chenqi Xu;Ligang Wu;Haisheng Zhou;Zhong Huang;Xuechao Zhang;Jun Li;Yanyan Wang;Yuhai Bi;Barry Rockx;Junfang Chen;Fei‐Long Meng... |
| 5 | Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2 | 期刊论文 | Tingting Li;Bingjie Zhou;Yaning Li;Suqiong Huang;Zhipu Luo;Yuanze Zhou;Yanling Lai;Anupriya Gautam;Salome Bourgeau;Shurui Wang;Juan Bao;Jingquan Tan;Dimitri Lavillette;Dianfan Li |
| 6 | 抗新型冠状病毒的中和抗体及其制备方法、制剂和用途 | 专利 | Dianfan.LI;谈静泉;迪米特里 拉维莱特 |
| 7 | Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release | 期刊论文 | Yitian Luo;Guoyue Wan;Xuan Zhou;Qiuwen Wang;Yunbin Zhang;Juan Bao;Yao Cong;Yun Zhao;Dianfan Li |
| 8 | An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification | 期刊论文 | Hongmin Cai;Hebang Yao;Tingting Li;Cedric A. J. Hutter;Yanfang Li;Yannan Tang;Markus A. Seeger;Dianfan Li |
| 9 | Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins | 期刊论文 | Yidan Xu;Guowen Jia;Tingting Li;Zixuan Zhou;Yitian Luo;Yulin Chao;Juan Bao;Zhaoming Su;Qianhui Qu;Dianfan Li |
| 10 | Developing a High-Throughput Assay for the Integral Membrane Glycerol 3-Phosphate Acyltransferase | 期刊论文 | Tang Yannan;Li Dianfan |
| 11 | High-level heterologous expression of the transmembrane human sterol Δ8,Δ7-isomerase in Pichia pastoris | 期刊论文 | Hongmin Cai;Hebang Yao;Tingting Li;Yannan Tang;Dianfan Li |
| 12 | Selenourea for Experimental Phasing of Membrane Protein Crystals Grown in Lipid Cubic Phase | 期刊论文 | Zhipu Luo;Weijie Gu;YichaoWan;Yannan Tang;Dianfan Li |
| 13 | Structure and Functional Characterization of Membrane Integral Proteins in the Lipid Cubic Phase | 期刊论文 | Dianfan Li;Martin Caffrey |
| 14 | A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection | 期刊论文 | Tingting Li;Hongmin Cai;Hebang Yao;Bingjie Zhou;Ning Zhang;Martje Fentener van Vlissingen;Thijs Kuiken;Wenyu Han;Corine H.GeurtsvanKessel;Yuhuan Gong;Yapei Zhao;Quan Shen;Wenming Qin;Xiao-Xu Tian;Chao Peng;Yanling Lai;Yanxing Wang;Cedric A. J.Hutter;Shu-Ming Kuo;Juan Bao;Caixuan Liu;Yifan Wang;Audrey S.Richard;Herve Raoul;Jiaming Lan;Markus A.Seeger;Yao Cong;Barry Rockx;Gary Wong;Yuhai Bi;Dimitr iLavillette;Dianfan Li |
| 15 | The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface | 期刊论文 | Bowei Yang;Hebang Yao;Dianfan Li;Zhenfeng Liu |
| 16 | 抗新型冠状病毒 SARS-CoV-2 的纳米抗体及其制备方法和用途 | 专利 | Dianfan.LI;谈静泉;迪米特里 拉维莱特 |
| 17 | Cryo-EM study of Patched in lipid nanodisc suggests a structural basis for its clustering in caveolae | 期刊论文 | Yitian Luo;Guoyue Wan;Xiang Zhang;Xuan Zhou;Qiuwen Wang;Jialin Fan;Hongmin Cai;Liya Ma;Hailong Wu;Qianhui Qu;Yao Cong;Yun Zhao;Dianfan Li |
| 18 | 一种抗新型冠状病毒SARS-CoV-2的抗体及其制备方法和用途 | 专利 | 李典范;李婷婷;李艳芳;赖燕玲;姚贺帮;蔡洪敏;劳蒂米;周冰洁;赵雅佩;孟飞龙;毕玉海;刘浏;张宁;王燕燕;龚玉环;陈剑峰;吴立刚;许琛琦;周海生;陈珺芳;孔庆鑫;孙昼;李钧;张学潮 |
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