系统性研究癌症中RNA剪接异常的病理功能和分子机理
31730110
2017
C0602.基因表达及非编码序列调控
王泽峰
重点项目
研究员
中国科学院上海营养与健康研究所
290万元
癌症;RNA结合蛋白/剪接因子;基因表达调控;可变剪接;转录组分析
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Study of circular RNA translation using reporter systems in living cells | 期刊论文 | Chen Chuyun;Yang Yun;Wang Zefeng |
| 2 | Up-regulated YB-1 protein promotes glioblastoma growth through an YB-1/CCT4/mLST8/mTOR pathway | 期刊论文 | Jin-Zhu Wang;Hong Zhu;Pu You;Hui Liu;Wei-Kang Wang;Xiaojuan Fan;Yun Yang;Keren Xu;Yingfeng Zhu;Qunyi Li;Ping Wu;Chao Peng;Catherine C.L.Wong;Kaicheng Li;Yufeng Shi;Nu Zhang;Xiuxing Wang;Rong Zeng;Ying Huang;Liusong Yang;Zefeng Wang;Jingyi Hui |
| 3 | Programmable RNA base editing with a single gRNA-free enzyme | 期刊论文 | Wenjian Han;Wendi Huang;Tong Wei;Yanwen Ye;Miaowei Mao;Zefeng Wang |
| 4 | Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets | 期刊论文 | Yongbo Wang;Yufang Bao;S.H. Zhang;Zefeng Wang |
| 5 | A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation | 期刊论文 | Wei Huan-Huan;Fan Xiao-Juan;Hu Yue;Tian Xiao-Xu;Guo Meng;Mao Miao-Wei;Fang Zhao-Yuan;Wu Ping;Gao Shuai-Xin;Peng Chao;Yang Yun;Wang Zefeng |
| 6 | Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells | 期刊论文 | Esgleas Miriam;Falk Sven;Forne Ignasi;Thiry Marc;Najas Sonia;Zhang Sirui;Mas-Sanchez Aina;Geerlof Arie;Niessing Dierk;Wang Zefeng;Imhof Axel;Goetz Magdalena |
| 7 | 利用人工构建RNA编辑酶进行RNA定点编辑及相关应用 | 专利 | 王泽峰;韩文建 |
| 8 | IRES-mediated cap-independent translation, a path leading to hidden proteome | 期刊论文 | Yun Yang;Zefeng Wang |
| 9 | SIRT1 regulatess, sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B | 期刊论文 | Fan Wei;Tang Shuang;Fan Xiaojuan;Fang Yi;Xu Xiaojiang;Li Leping;Xu Jian;Li Jian-Liang;Wang Zefeng;Li Xiaoling |
| 10 | Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity | 期刊论文 | Adam C O'Neill;Fatma Uzbas;Giulia Antognolli;Florencia Merino;Kalina Draganova;Alex Jäck;Sirui Zhang;Giorgia Pedini;Julia Schessner;Kimberly Cramer;Aloys Schepers;Fabian Metzger;Miriam Esgleas;Pawel Smialowski;Renzo Guerrini;Sven Falk;Regina Feederle;Saskia Freytag;Zefeng Wang;Melanie Bahlo;Ralf Jungmann;Claudia Bagni;Georg H. H. Borner;Stephen P. Robertson;Stefanie M. Hauck;Magdalena Götz |
| 11 | 利用癌症中剪接异常的短外显子辅助癌症诊断和预后 | 专利 | 王泽峰;张思蕊 |
| 12 | TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence | 期刊论文 | Wendi Huang;Yunchao Ling;S.H. Zhang;Qiguang Xia;Ruifang Cao;Xiaojuan Fan;Zhaoyuan Fang;Zefeng Wang;Guoqing Zhang |
| 13 | A widespread length-dependent splicing dysregulation in cancer | 期刊论文 | Sirui Zhang;Miaowei Mao;Yuesheng Lv;Yingqun Yang;Weijing He;Yongmei Song;Yongbo Wang;Yun Yang;Muthana Al Abo;Jennifer A. Freedman;Steven R. Patierno;Yang Wang;Zefeng Wang |
| 14 | Pervasive translation of circular RNAs driven by short IRES-like elements | 期刊论文 | Xiaojuan Fan;Yun Yang;Chuyun Chen;Zefeng Wang |
| 15 | 利用环形RNA进行蛋白翻译及相关应用 | 专利 | 王泽峰;杨赟;樊晓娟 |
| 16 | RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H | 期刊论文 | Zhang Sirui;Bao Yufang;Shen Xianfeng;Pan Yunjian;Sun Yue;Xiao Man;Chen Kexuan;Wei Huanhuan;Zuo Ji;Saffen David;Zong Wei-Xing;Sun Yihua;Wang Zefeng;Wang Yongbo |
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