孤雄单倍体胚胎干细胞携带CRISPR-Cas9文库用于筛选胚胎发育关键因子的研究
31530048
2015
C1201.干细胞基础研究
李劲松
重点项目
研究员
中国科学院分子细胞科学卓越创新中心
278万元
遗传筛选;CRISPR-Cas9技术;孤雄单倍体胚胎干细胞;单倍剂量不足;半克隆技术
2016-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1 | 期刊论文 | Qi Yin;Hongye Wang;Na Li;Yifu Ding;Zhenfei Xie;Lifang Jin;Yan Li;Qiong Wang;Xinyi Liu;Liuqing Xu;Qing Li;Yongjian Ma;Yanbo Cheng;Kai Wang;Cuiqing Zhong1;Qian Yu;Wei Tang;Wanjin Chen;Wenjun Yang;Fan Zhang;Chen Ding;Lan Bao;Bin Zhou;Ping Hu;Jinsong Li |
| 2 | CRISPR-Cas9-mediated genome-editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development | 期刊论文 | Wang L;Li MY;Qu C;Miao WY;Yin Q;Liao J;Cao HT;Huang M;Wang K;Zuo E;Peng G;Zhang SX;Chen G;Li Q;Tang K;Yu Q;Li Z;Wong C;Xu G;Jing N;Yu X;Li Jinsong |
| 3 | 2019年上海市科技精英提名奖 | 奖励 | 李劲松 |
| 4 | Haploid embryonic stem cells can be enriched and maintained by simple filtration | 期刊论文 | Qu Chao;Yan Meng;Yang Suming;Wang Lingbo;Yin Qi;Liu Yuan;Chen Yeguang;Li Jinsong |
| 5 | Efficient generation of the mouse model with a defined point mutation through haploid cell-mediated gene-editing | 期刊论文 | Wei L;Wang X;Yang S;Yuan W;Li Jinsong |
| 6 | In vitro expansion of human sperm through nuclear transfer | 期刊论文 | Xiaoyu Merlin Zhang;Keliang Wu;Yuxuan Zheng;Han Zhao;Junpeng Gao;Zhenzhen Hou;Meiling Zhang;Jiaoyang Liao;Jingye Zhang;Yuan Gao;Yuanyuan Li;Lin Li;Fuchou Tang;Zi-Jiang Chen;Li Jinsong |
| 7 | 2017年“上海市自然科学一等奖”《卵子介导细胞重编程的基础与应用研究》 | 奖励 | 李劲松 |
| 8 | Generation and application of mammalian haploid embryonic stem cells | 期刊论文 | Bai M;Wu Y;Li Jinsong |
| 9 | CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development | 期刊论文 | Li Qing;Li Y;Yang S;Huang S;Yan M;Ding Y;Tang W;Lou X;Yin Q;Sun Z;Lu L;Shi H;Wang H;Chen Y;Li Jinsong |
| 10 | 2017年中国科学院优秀导师奖 | 奖励 | 李劲松 |
| 11 | 2016年细胞生物学会干细胞分会“干细胞社会公益奖” | 奖励 | 李劲松 |
| 12 | 2016中组部万人计划 | 奖励 | 李劲松 |
| 13 | PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis | 期刊论文 | Wang Xiukun;Kang Jun Yan;Wei Leixin;Yang Xiaogan;Sun Hongduo;Yang Suming;Lu Lei;Yan Meng;Bai Meizhu;Chen Yanyan;Long Juanjuan;Li Na;Li Dangsheng;Huang Jing;Lei Ming;Shao Zhen;Yuan Wen;Zuo Erwei;Lu Kehuan;Liu Mo Fang;Li Jinsong |
| 14 | Efficient generation of gene-modified mice by haploid embryonic stem cell-mediated semi-cloned technology | 期刊论文 | Zhong C;Li Jinsong |
| 15 | 哺乳动物单倍体胚胎干细胞的建立与应用 | 期刊论文 | 丁一夫;李劲松;周琪 |
| 16 | The evolving CRISPR technology | 期刊论文 | Yan Meng;Li Jinsong |
| 17 | Spermatogenic cell-specific gene mutation in mice via CRISPR-Cas9 | 期刊论文 | Bai M;Liang D;Wang Y;Li Q;Wu Y;Li Jinsong |
| 18 | Temporal regulation of prenatal embryonic development by paternal imprinted loci. | 期刊论文 | Li Qing;Li Yuanyuan;Yin Qi;Huang Shuo;Wang Kai;Zhuo Liangchai;Li Wei;Chang Boran;Li Jinsong |
| 19 | 2019年中国科学院朱李月华优秀教师奖 | 奖励 | 李劲松 |
| 20 | 2016年中组部“万人计划” | 奖励 | 李劲松 |
| 21 | CRISPR/Cas9系统应用于早期胚胎编辑和基因治疗 | 期刊论文 | 张晓宇;唐蔚;李劲松 |
| 22 | Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development | 期刊论文 | Bai Meizhu;Han Yujiao;Wu Yuxuan;Liao Jiaoyang;Li Lin;Wang Lijun;Li Qing;Xing Wenhui;Chen Luonan;Zou Weiguo;Li Jinsong |
| 23 | An intermediate cell state allows rerouting of cell fate | 期刊论文 | Wang Xiukun;Li Jinsong |
| 24 | Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development | 期刊论文 | Yang Xianfa;Hu Boqiang;Liao Jiaoyang;Qiao Yunbo;Chen Yingying;Qian Yun;Feng Su;Yu Fang;Dong Ji;Hou Yu;Xu He;Wang Ran;Peng Guangdun;Li Jinsong;Tang Fuchou;Jing Naihe |
| 25 | Technical advances contribute to the study of genomic imprinting | 期刊论文 | Li Yuanyuan;Li Jinsong |
| 26 | Genome tagging project: tag every protein in mouse through “artificial spermatids” | 期刊论文 | Jiang Jin;Yan Meng;Li Dangsheng;Li Jinsong |
| 27 | 2016年光华工程科技奖 | 奖励 | 李劲松 |
| 28 | 2019年(第十八届)上海市医学科技奖一等奖《女性生殖障碍疾病防治和辅助生殖助孕策略优化及推广应用》 | 奖励 | 孙贇;杜艳芝;胡双纲;朱琴玲;齐家;金颖;李劲松;杨辉;章美玲;洪燕 |
| 29 | CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells | 期刊论文 | Wang Y;Ding Y;Li Jinsong |
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