原肠运动过程中外胚层的命运决定及表观遗传调控
31430058
2014
C1203.早期胚胎发育及细胞谱系建立
景乃禾
重点项目
研究员
中国科学院分子细胞科学卓越创新中心
344万元
外胚层;表观遗传修饰;原肠运动;小鼠胚胎;细胞谱系
2015-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models | 期刊论文 | Yue Wei;Li Yuanyuan;Zhang Ting;Jiang Man;Qian Yun;Zhang Min;Sheng Nengyin;Feng Su;Tang Ke;Yu Xiang;Shu Yousheng;Yue Chunmei;Jing Naihe |
| 2 | Derivation of Haploid Neurons from Mouse Androgenetic Haploid Embryonic Stem Cells | 期刊论文 | Xu He;Yue Chunmei;Zhang Ting;Li Yuanyuan;Guo Ao;Liao Jiaoyang;Pei Gang;Li Jinsong;Jing Naihe |
| 3 | Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development | 期刊论文 | Xianfa Yang et. al.;Naihe jing |
| 4 | TGF-beta signaling pathway in early mouse development and embryonic stem cells | 期刊论文 | Liu Chang;Peng Guangdun;Jing Naihe |
| 5 | 从上胚层干细胞建立外胚层干细胞的方法 | 专利 | 景乃禾;刘畅 |
| 6 | Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation. | 期刊论文 | Friedman Clayton E;Nguyen Quan;Lukowski Samuel W;Helfer Abbigail;Chiu Han Sheng;Miklas Jason;Levy Shiri;Suo Shengbao;Han Jing-Dong Jackie;Osteil Pierre;Peng Guangdun;Jing Naihe;Baillie Greg J;Senabouth Anne;Christ Angelika N;Bruxner Timothy J;Murry Charles E;Wong Emily S;Ding Jun;Wang Yuliang;Hudson James;Ruohola-Baker Hannele;Bar-Joseph Ziv;Tam Patrick P L;Powell Joseph E;Palpant Nathan J |
| 7 | The promise of stem cells in the therapy of Alzheimer's disease. | 期刊论文 | Yue Chunmei;Jing Naihe |
| 8 | Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells | 期刊论文 | Liu Chang;Wang Ran;Yang Xianfa;Chen Jun;Cui Guizhong;Guo Wenke;Chen Yingying;Peng Guangdun;Jing Naihe;He Zhisong;Osteil Pierre;Wilkie Emilie;Tam Patrick P. L.;Wilkie Emilie;Yang Xianfa;Guo Wenke;Chen Yingying;Jing Naihe;Tam Patrick P. L.;Jing NH;Jing NH |
| 9 | Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq | 期刊论文 | Chen Jun;Suo Shengbao;Tam Patrick P L;Han Jing Dong J;Peng Guangdun;Jing Naihe |
| 10 | Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency | 期刊论文 | Tan Fangzhi;Qian Cheng;Tang Ke;Abd Allah Saber Mohamed;Jing Naihe |
| 11 | Molecular architecture of lineage allocation and tissue organization in early mouse embryo. | 期刊论文 | Peng Guangdun;Suo Shengbao;Cui Guizhong;Yu Fang;Wang Ran;Chen Jun;Chen Shirui;Liu Zhiwen;Chen Guoyu;Qian Yun;Tam Patrick P L;Han Jing Dong J;Jing Naihe |
| 12 | Genome-wide ChIP-seq and RNA-seq analyses of Pou3f1 during mouse pluripotent stem cell neural fate commitment. | 期刊论文 | Song Lu;Sun Na;Peng Guangdun;Chen Jun;Han Jing-Dong Jackie;Jing Naihe |
| 13 | AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation. | 期刊论文 | Qiao Yunbo;Wang Xiongjun;Wang Ran;Li Yuanyuan;Yu Fang;Yang Xianfa;Song Lu;Xu Guoliang;Chin Y Eugene;Jing Naihe |
| 14 | Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development | 期刊论文 | Han Xue;Luo Sai;Peng Guangdun;Lu J. Yuyang;Cui Guizhong;Liu Lichao;Yan Pixi;Yin Yafei;Liu Wei;Wang Ran;Zhang Jiejie;Ai Shanshan;Chang Zai;Na Jie;He Aibin;Jing Naihe;Shen Xiaohua |
| 15 | Lineage specification of early embryos and embryonic stem cells at the dawn of enabling technologies | 期刊论文 | Peng Guangdun;Tam Patrick P. L.;Jing Naihe |
| 16 | 建立自外周血单核细胞的神经前体细胞及其构建方法 | 专利 | 景乃禾;张婷 |
| 17 | The genome-wide molecular regulation of mouse gastrulation embryo | 期刊论文 | Peng Guangdun;Jing Naihe |
| 18 | TGF beta signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs | 期刊论文 | Yang Xianfa;Wang Ran;Cai Guoqing;Qian Yun;Feng Su;Jing Naihe;Yang Xianfa;Wang Ran;Cai Guoqing;Qian Yun;Feng Su;Jing Naihe;Yang Xianfa;Tan Fangzhi;Huang Xingxu;Jing Naihe;Wang Xiongjun;Chen Kun;Tang Ke;Qiao Yunbo;Jing NH;Jing NH;Jing NH;Qiao YB |
| 19 | Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells. | 期刊论文 | Li Yuanyuan;Wang Ran;Qiao Nan;Peng Guangdun;Zhang Ke;Tang Ke;Han Jing-Dong J;Jing Naihe |
| 20 | Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling | 期刊论文 | Song Lu;Chen Jun;Peng Guangdun;Tang Ke;Jing Naihe |
| 21 | Human Neural Stem Cells Reinforce Hippocampal Synaptic Network and Rescue Cognitive Deficits in a Mouse Model of Alzheimer's Disease | 期刊论文 | Ting Zhang et. al.;Naihe Jing |
| 22 | Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning | 期刊论文 | Guizhong Cui;Shengbao Suo;Ran Wang;Yun Qian;Jing‐Dong J. Han;Guangdun Peng;Patrick P. L. Tam;Naihe Jing |
| 23 | Hedgehog信号通路抑制剂治疗自闭症的用途 | 专利 | 景乃禾;张轲;唐珂 |
| 24 | Comments on 'Molecular architecture of lineage allocation and tissue organization in early mouse embryo'. | 期刊论文 | Guizhong Cui;Naihe Jing;Guangdun Peng |
| 25 | Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate | 期刊论文 | Liu Pingyu;Dou Xiaoyang;Liu Chang;Wang Lingbo;Xing Can;Peng Guangdun;Chen Jun;Yu Fang;Qiao Yunbo;Song Lu;Wu Yuxuan;Yue Chunmei;Li Jinsong;Han Jing-Dong J.;Tang Ke;Jing Naihe |
| 26 | 从多潜能干细胞诱导胆碱能神经元的方法 | 专利 | 景乃禾;岳伟 |
| 27 | Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages | 期刊论文 | Yang Xianfa;Hu Boqiang;Hou Yu;Qiao Yunbo;Wang Ran;Chen Yingying;Qian Yun;Feng Su;Chen Jun;Liu Chang;Peng Guangdun;Tang Fuchou;Jing Naihe |
| 28 | A gene regulatory network anchored by LIM homeobox 1 for embryonic head development | 期刊论文 | Tennille Sibbritt;Chi K. Ip;Poh‐Lynn Khoo;Emilie Wilkie;Vanessa Jones;Jane Q. J. Sun;Joanne X. Shen;Guangdun Peng;Jing‐Dong J. Han;Naihe Jing;Pierre Osteil;Mirana Ramialison;Patrick P. L. Tam;Nicolas Fossat |
| 29 | Genome-wide analysis of histone acetylation dynamics during mouse embryonic stem cell neural differentiation. | 期刊论文 | Liu Pingyu;Dou Xiaoyang;Peng Guangdun;Han Jing-Dong Jackie;Jing Naihe |
| 30 | BMP信号在中枢神经系统发育中的作用机制 | 奖励 | 景乃禾;白戈;张克兢;程乐平;陈德桂 |
| 31 | Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo | 期刊论文 | Peng Guangdun;Suo Shengbao;Chen Jun;Chen Weiyang;Liu Chang;Yu Fang;Wang Ran;Chen Shirui;Sun Na;Cui Guizhong;Song Lu;Tam Patrick P. L.;Han Jing-Dong J.;Jing Naihe |
| 32 | Epigenetic regulation of early neural fate commitment | 期刊论文 | Qiao Yunbo;Yang Xianfa;Jing Naihe |
| 33 | Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling | 期刊论文 | Li Lingyu;Song Lu;Liu Chang;Chen Jun;Peng Guangdun;Wang Ran;Liu Pingyu;Tang Ke;Rossant Janet;Jing Naihe |
| 34 | Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation. | 期刊论文 | Qiao Yunbo;Wang Ran;Yang Xianfa;Tang Ke;Jing Naihe |
| 35 | 银杏内酯A治疗自闭症的用途 | 专利 | 景乃禾;张轲;唐珂 |
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