饮食胆固醇吸收的分子机制与功能调控
31230020
2012
C0506.糖、脂生物化学
宋保亮
重点项目
教授
中国科学院分子细胞科学卓越创新中心
309万元
小肠;高脂血症;NPC1L1;动脉粥样硬化;饮食胆固醇吸收;脂筏
2013-01-01到2017-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling. | 期刊论文 | Xiao Xu;Tang Jing-Jie;Peng Chao;Wang Yan;Fu Lin;Qiu Zhi-Ping;Xiong Yue;Yang Lian-Fang;Cui Hai-Wei;He Xiao-Long;Yin Lei;Qi Wei;Wong Catherine C L;Zhao Yun;Li Bo-Liang;Qiu Wen-Wei;Song Bao-Liang |
| 2 | Routes and mechanisms of post-endosomal cholesterol trafficking: A story that never ends. | 期刊论文 | Luo Jie;Jiang Luyi;Yang Hongyuan;Song Bao-Liang |
| 3 | The clathrin adaptor proteins ARH, Dab2, and numb play distinct roles in Niemann-Pick C1-Like 1 versus low density lipoprotein receptor-mediated cholesterol uptake. | 期刊论文 | Wei Jian;Fu Zhen-Yan;Li Pei-Shan;Miao Hong-Hua;Li Bo-Liang;Ma Yi-Tong;Song Bao-Liang |
| 4 | The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes. | 期刊论文 | Wei Jian;Zhang Ying-Yu;Luo Jie;Wang Ju-Qiong;Zhou Yu-Xia;Miao Hong-Hua;Shi Xiong-Jie;Qu Yu-Xiu;Xu Jie;Li Bo-Liang;Song Bao-Liang |
| 5 | The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. | 期刊论文 | Li Pei-Shan;Fu Zhen-Yan;Zhang Ying-Yu;Zhang Jin-Hui;Xu Chen-Qi;Ma Yi-Tong;Li Bo-Liang;Song Bao-Liang |
| 6 | Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis. | 期刊论文 | Jiang Wei;Tang Jing-Jie;Miao Hong-Hua;Qu Yu-Xiu;Qin Jie;Xu Jie;Yang Jinbo;Li Bo-Liang;Song Bao-Liang |
| 7 | 2‑羟丙基‑β‑环化糊精在制备治疗X‑连锁肾上腺脑白质退化症的药物中的应用 | 专利 | 宋保亮;储贝贝;廖雅成 |
| 8 | AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease. | 期刊论文 | Xie Chang;Gong Xue-Min;Luo Jie;Li Bo-Liang;Song Bao-Liang |
| 9 | Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation. | 期刊论文 | Wang Yong-Jian;Bian Yan;Luo Jie;Lu Ming;Xiong Ying;Guo Shu-Yuan;Yin Hui-Yong;Lin Xu;Li Qin;Chang Catherine C Y;Chang Ta-Yuan;Li Bo-Liang;Song Bao-Liang |
| 10 | Cholesterol transport through lysosome-peroxisome membrane contacts. | 期刊论文 | Chu Bei-Bei;Liao Ya-Cheng;Qi Wei;Xie Chang;Du Ximing;Wang Jiang;Yang Hongyuan;Miao Hong-Hua;Li Bo-Liang;Song Bao-Liang |
| 11 | Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome. | 期刊论文 | Xie Chang;Zhang Ya-Ping;Song Lu;Luo Jie;Qi Wei;Hu Jialu;Lu Danbo;Yang Zhen;Zhang Jian;Xiao Jian;Zhou Bin;Du Jiu-Lin;Jing Naihe;Liu Yong;Wang Yan;Li Bo-Liang;Song Bao-Liang;Yan Yan |
| 12 | Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice. | 期刊论文 | Li Na;Zhou Zhang-Sen;Shen Yang;Xu Jie;Miao Hong-Hua;Xiong Ying;Xu Feng;Li Bo-Liang;Luo Jie;Song Bao-Liang |
| 13 | Routes and mechanisms of post-endosomal cholesterol trafficking: A story that never ends. | 期刊论文 | Luo Jie;Jiang Luyi;Yang Hongyuan;Song Bao-Liang |
| 14 | Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice. | 期刊论文 | Li Na;Zhou Zhang-Sen;Shen Yang;Xu Jie;Miao Hong-Hua;Xiong Ying;Xu Feng;Li Bo-Liang;Luo Jie;Song Bao-Liang |
| 15 | Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome. | 期刊论文 | Xie Chang;Zhang Ya-Ping;Song Lu;Luo Jie;Qi Wei;Hu Jialu;Lu Danbo;Yang Zhen;Zhang Jian;Xiao Jian;Zhou Bin;Du Jiu-Lin;Jing Naihe;Liu Yong;Wang Yan;Li Bo-Liang;Song Bao-Liang;Yan Yan |
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