【30830037】RKTG对ERK信号通路的调控和肿瘤生成的影响国家自然基金项目 - 国家自然科学基金查询网

RKTG对ERK信号通路的调控和肿瘤生成的影响

项目批准号： 30830037

批准年份： 2008

学科分类： C0505.蛋白质、多肽与酶生物化学

项目负责人：陈雁

资助类别：重点项目

负责人职称：研究员

依托单位：中国科学院上海营养与健康研究所

资助金额： 190万元

关键词： Carcinogenesis;ERK;animal;Ras;RKTG;models

起止时间： 2009-01-01到2012-12-31

中英文摘要
结题摘要
结题报告
项目成果
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序号	标题	类型	作者
1	Regulation of G protein signaling by RKTG via sequestrating Gbetagamma subunit to Golgi apparatus.	期刊论文	Jiang YH\|Xie XD\|Zhang YX\|Luo XL\|Wang X\|Fan FJ\|Zheng DW\|Wang ZZ\|Chen Y\|
2	Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis.	期刊论文	Luo, X\|Wang, Z\|Chen, Y\|Zhang, Y\|Ruan, X\|Jiang, X\|Zhu, L\|Wang, X\|Ding, Q\|Liu, W\|Pan, Y\|
3	Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition	期刊论文	Jiang, Y\|Xie, X\|Li, Z\|Wang, W\|Zhang, Y\|Ling, Z\|Pan, Y\|Wang. Z\|Chen, Y\|
4	PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110a to the Golgi apparatus.	期刊论文	Xiao Wang\|Walter G. Thomas\|Yan Chen\|Lingdi Wang\|Lu Zhu\|Yi Pan\|Fei Xiao\|Weizhong Liu\|Zhenzhen Wang\|Feifan Guo\|Yong Liu\|
5	Identification of the topology and functional domains of PAQR10	期刊论文	Jin, T\|Xu, D\|Ding, Q\|Zhang, Y\|Mao, C\|Pan, Y\|Wang, Z\|Chen, Y\|
6	PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus	期刊论文	Jin T\| Liu WZ\|Zhang YX\|Pan Y\|Wang ZZ\|Thomas WG\|Chen Y\|Ding QR\|Huang H\| Xu DQ\|Jiang YH\|Zhou B\|Li ZH\|Jiang XM\| He J\|
7	Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and upregulation of UCP1 in brown fat.	期刊论文	Ruan XB\|Li ZH\|Zhang YX\|Yang L\|Pan Y\|Wang ZZ\|Feng GS\|Chen Y\|
8	In Vivo Disruption of TGF-b Signaling by Smad7 in Airway Epithelium Alleviates Allergic Asthma but Aggravates Lung Carcinogenesis in Mouse.	期刊论文	Luo XL\|Chen Y\|Ding QR\|Wang M\|Li ZG\|Mao KR\|Sun B\|Pan Y\|Wang ZZ\|Zang Qin Y\|
9	RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrineVEGF signaling and is downregulated in clear-cell renal cell carcinoma.	期刊论文	Y Zhang\|Z Wang\|J Fang\|Y. Chen\|X Jiang\|X Qin\|D Ye\|Z Yi\|M Liu\|O Bai\|W Liu\|X Xie\|
10	Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury	期刊论文	Zhu, L\|Chen, Y\|Wang, L\|Wang, X\|Luo, X\|Yang, L\|Zhang, R\|Yin, H\|Xie, X\|Pan, Y\|
11	Progesterone and AdipoQ Receptor 11 Links Ras Signaling to Cardiac Development in Zebrafish	期刊论文	Heng Hang\|Yan Chen\|Ting Jin\|Jing He\|Qiurong Ding\|Daqian Xu\|Lingdi Wang\|Yixuan Zhang\|Yi Pan\|Zhenzhen Wang\|
12	The RAS guanyl nucleotide-releasing protein RasGRP1 is involved in lymphatic development in zebrafish	期刊论文	Heng Huang\|Ting Jin\|Lin Wang\| Fulong Wang\| Rui Zhang\| Yi Pan\|Zhenzhen Wang\|Chen Yan\|
13	Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22.	期刊论文	Yang L\|Huang ZH\|Huang YL\|Yan XQ\|Chen Y\|Zhang YX\|Wang LD\|Fan FJ\|Zhu L\|Li ZH\|Ruan XB\|Huang H\|Wang ZZ\|
14	High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22.	期刊论文	Wang, Z\|Wang, ZZ\|Yan, XQ\|Chen, Y\|Yang, L\|Jiang YH\|Ling ZQ\|Li, ZG\|Cheng, Y\|Huang, H\|Wang, L\|Pan, Y\|
15	Tollip, an Intracellular Trafficking Protein, Is a Novel Modulator of the Transforming Growth Factor-beta Signaling Pathway	期刊论文	Lu Zhu\|Lingdi Wang\|Xiaolin Luo\|Yongxian Zhang\|Qiurong Ding\|Xiaomeng Jiang\|Xiao Wang\|Yi Pan\|Yan Chen\|
16	PAQR3 Plays a Suppressive Role in the Tumorigenesis of Colorectal Cancers	期刊论文	Xiao Wang\|Jing Fang\|Yan Chen\|Xuebing Li\|Fengjuan Fan\|Shi Jiao\|Lingdi Wang\|Lu Zhu\|Yi Pan\|Guohao Wu\|Zhi-Qiang Ling\|

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