参与组蛋白修饰的重要蛋白质和蛋白质复合物的结构与功能研究

30730028
2007
C0505.蛋白质、多肽与酶生物化学
丁建平
重点项目
研究员
中国科学院分子细胞科学卓越创新中心
160万元
分子机制;转录调控;结构和功能;蛋白-蛋白相互作用;组蛋白修饰
2008-01-01到2011-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 期刊论文 Zhou, Yanfeng|Graeter, Frauke|Ding, Jianping|Dong, Xianchi|Luo, Xinping|Baldauf, Carsten|Zhou, Minyun|Springer, Timothy A.|Zhong, Chen|Chen, Hua|
2 Efalizumab binding to the LFA-1 alpha(L) I domain blocks ICAM-1 binding via steric hindrance 期刊论文 Guo, Yajun|Ding, Jianping|Zhang, Daipong|Peng, Baozhen|Hou, Sheng|Wang, Hao|Zhang, Meilan|Li, Sheng|
3 Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans 期刊论文 Ma, Jun|Zha, Manwu|Ding, Jianping|Zhang, Peng|Zhao, Guoping|Zhang, Zilong|Xu, Hai|
4 Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding 期刊论文 Xu, Shutong|Sun, Bingfa|Zhong, Chen|Wu, Jian|Ding, Jianping|
5 Structural modeling and biochemical studies reveal insights into the molecular basis of the recognition of beta-2-microglobulin by antibody BBM.1 期刊论文 Ding, Jianping|Yang, Hui|Peng, Baozhen|Du, Jiamu|
6 Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism 期刊论文 Zhang, Tianlong|Ding, Jianping|Peng, Yingjie|Wang, Bing|
7 Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design 期刊论文 Shen, Ning|Dong, Xianchi|Zhong, Chen|Ding, Jianping|Zhou, Minyun|
8 Structural Basis for the Blockage of IL-2 Signaling by Therapeutic Antibody Basiliximab 期刊论文 Yang, Hui|Guo, Yajun|Peng, Baozhen|Ding, Jianping|Guo, Huaizu|Wang, Jianchuan|Du, Jiamu|Zhang, Dapeng|
9 Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20 期刊论文 Du, Jiamu|Ding, Jianping|Yang, Hui|Guo, Yajun|
10 Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies 期刊论文 Guo, Qing|Ding, Jianping|Zhong, Chen|Yu, Biao|Ou, Ying|Zha, Manwu|Zhang, Yichun|
11 Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans 期刊论文 Zhang, Zilong|Zha, Manwu|Xu, Hai|Zhao, Guoping|Ding, Jianping|Zhang, Peng|Ma, Jun|
12 Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site 期刊论文 Ding, Jianping|Du, Jiamu|Zhang, Peng|Li, Yingjie|
13 Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide 期刊论文 Wang, Hao|Ding, Jianping|Peng, Baozhen|Du, Jiamu|Li, Bohua|Guo, Yajun|Zhang, Meilan|Hou, Sheng|Zhong, Chen|
14 Crystal Structure of the ARL2-GTP-BART Complex Reveals a Novel Recognition and Binding Mode of Small GTPase with Effector 期刊论文 Ding, Jianping|Zhang, Tianlong|Zhang, Yichen|Lai, Zheng|Zhong, Chen|Li, Sheng|
15 Molecular Basis of the Acceleration of the GDP-GTP Exchange of Human Ras Homolog Enriched in Brain by Human Translationally Controlled Tumor Protein 期刊论文 Dong, Xianchi|Zhong, Chen|Li, Yingjie|Yang, Bei|Ding, Jianping|
16 Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer 期刊论文 Wu Lijing|Zhou Jin-qiu|Zhang Tianlong|Zhong Chen|Tao Ye|Ding Jianping|Li Hong-tao|Yang Hui|
17 Molecular Basis of the Interaction of Saccharomyces cerevisiae Eaf3 Chromo Domain with Methylated H3K36 期刊论文 Shen, Xu|Hong, Jing|Dong, Xianchi|Lin, Donghai|Sun, Bingfa|Zhang, Peng|Ding, Jianping|
18 Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states 期刊论文 Yu, Yadong|Dong, Xianchi|Shen, Ning|Ding, Jianping|Zhou, Minyu|Yang, Bei|
19 Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid arthritis 期刊论文 Hou, Sheng|Zhang, Dapeng|Zhong, Chen|Dai, Jianxin|Yang, Hui|Guo, Yajun|Ding, Jianping|Du, Jiamu|Lai, Zheng|Wang, Hao|
20 Structural basis of immunosuppression by the therapeutic antibody daclizumab 期刊论文 Ding, Jianping|Zhong, Chen|Yang, Hui|Zhang, Dapeng|Wang, Jianchuan|Du, Jiamu|Guo, Huaizu|Guo, Yajun|
21 Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H 期刊论文 Ding, Jianping|Peng, Yingjie|Lai, Zheng|Yang, Bei|Zhong, Chen|
22 Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274 期刊论文 Li, Chen|Sun, Bingfa|Tang, Qingyu|Guo, Shunling|Ding, Jianping|Zeng, Rong|Zhong, Chen|Xiong, Zhiqi|
23 Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase 期刊论文 Zhong, Chen|Yang, Bei|Dong, Xianchi|Zhou, Minyun|Ding, Jianping|Shen, Ning|
24 Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism 期刊论文 Wu, Jian|Chang, Yuanyuan|Tong, Xia-Jing|Ding, Jianping|Zhou, Jin-Qiu|
25 Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins 期刊论文 Xu, Shutong|Zhong, Chen|Ding, Jianping|Zhang, Tianlong|
26 Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction 期刊论文 Peng, Yingjie|Zhong, Chen|Ding, Jianping|Huang, Wei|
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