花色苷类植物化学物抗动脉粥样硬化效应及分子机制研究

30730079
2007
H3003.人类营养
凌文华
重点项目
教授
中山大学
160万元
动脉粥样硬化;炎性反应;花色苷;胆固醇逆向转运;核受体
2008-01-01到2011-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Protocatechuic acid, a metabolite of anthocyanins, inhibits monocyte adhesion and reduces atherosclerosis in apolipoprotein E-deficient mice. 期刊论文 Wang D, Wei X, Yan X, Jin T, Ling W|
2 Cyanidin-3-O -β-glucoside upregulates hepatic cholesterol 7-hydroxylase expression and reduces hypercholesterolemia in mice. 期刊论文 1. Wang DL, Xia M, Gao S, Li D, Zhang Y, Ling WH|
3 Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity. 期刊论文 Wei X, Wang D, Yang Y, Xia M, Li D, Li G, Zhu Y|
4 动脉粥样硬化的病理机制以及花色苷防治研究 奖励 凌文华|
5 Cyanidin-3-O-beta-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IkappaBalpha phosphorylation in THP-1 cells. 期刊论文 Zhang Y, Lian F, Zhu Y, Xia M, Wang Q, Ling W|
6 Cyanidin-3-O-β-glucoside with the aid of its metabolite protocatechuic acid, reduces monocyte infiltration in apolipoprotein E-deficient mice. 期刊论文 Wang D, Zou T, Yang Y, Yan X, Ling W|
7 动脉粥样硬化的病理机制以及花色苷防治研究 奖励 凌文华|
8 Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages. 期刊论文 Wang Q, Xia M, Liu C, Ling W|
9 植物花色苷 专著 凌文华，郭红辉|
10 Anthocyanin inhibits high glucose- induced hepatic mitochondrial glycerol-sn-3-phosphate acyltransferase 1 activation and prevents fatty acid synthesis through protein kinase C zeta. 期刊论文 Guo H, Li D, Ling W, Feng X, Xia M|
11 Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. 期刊论文 Li D, Zhang Y, Ma J, Ling WH, Xia M|
12 Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. 期刊论文 Qin Y, Xia M, Ma J, Hao Y, Liu J, Mou H, Ling W|
13 Phosphoinositide 3-kinase mediates CD40 ligand- induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2. 期刊论文 Xia M, Li G, Ma J, Ling W|
14 Relationship between lipid profiles and plasma total homocysteine, cysteine and the risk of coronary artery disease in coronary angiographic subjects. 期刊论文 Xiao Y, Zhang Y, Lv X, Xia M, Qiu J, Ling W, Ma J|
15 Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. 期刊论文 Zhu Y, Xia M, Yang Y, Liu F, Hao Y, Mi M, Ling W|
16 Structural requirements of anthocyanins in relation to inhibition of endothelial injury induced by oxidized low-density lipoprotein and correlation with radical scavenging activity 期刊论文 Yi L, Chen CY, Jin X, Mi MT, Yu B, Ling WH|
17 Adenosine monophosphate- activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. 期刊论文 Li D, Wang D, Wang Y, Ling W, Feng X, Xia M|
18 Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet–fed and db/db mice via the transcription factor FoxO1. 期刊论文 Guo HH, Xia M, Zhou TB, Ling WH, Zhong RM, Zha|
19 Delphinidin attenuates stress injury induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells. 期刊论文 Chen CY, Yi L, Jin X, Mi MT, Zhang T, Ling WH, |
20 全国优秀博士学位论文指导教师 奖励 凌文华|
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