大气细颗粒物暴露引发心肌功能失常的作用和分子机制
91743104
2017
B0607.环境毒理与健康
陆忠兵
重大研究计划
教授
中国科学院大学
80万元
炎症;氧化应激;心肌肥厚;单磷酸腺苷活化蛋白激酶;大气细颗粒
2018-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. | 期刊论文 | Wang Yue;Lei Tong;Yuan Juntao;Wu Yongguang;Shen Xiyue;Gao Junling;Feng Wei;Lu Zhongbing |
| 2 | TMT-Based Quantitative Proteomics Analysis Reveals Airborne PM2.5-Induced Pulmonary Fibrosis | 期刊论文 | Liu Shan;Zhang Wei;Zhang Fang;Roepstorff Peter;Yang Fuquan;Lu Zhongbing;Ding Wenjun |
| 3 | GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation | 期刊论文 | Guo Yuting;Wang Huiwen;Tang Yinglong;Wang Yue;Zhang Mengqi;Yang Zhiguang;Nyirimigabo Eric;Wei Bin;Lu Zhongbing;Ji Guangju |
| 4 | The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis | 期刊论文 | Wang Hongyun;Shen Xiyue;Liu Jingli;Wu Chunyan;Gao Junling;Zhang Zezhong;Zhang Fang;Ding Wenjun;Lu Zhongbing |
| 5 | Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy | 期刊论文 | Yue Wenhui;Tong Lei;Liu Xiaohong;Weng Xinyu;Chen Xiaoyu;Wang Dongzhi;Dudley Samuel C;Weir E Kenneth;Ding Wenjun;Lu Zhongbing;Xu Yawei;Chen Yingjie |
| 6 | GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. | 期刊论文 | Liu Shasha;Yuan Juntao;Yue Wenhui;Bi Yanwei;Shen Xiyue;Gao Junling;Xu Xin;Lu Zhongbing |
| 7 | AMPK alpha 2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction | 期刊论文 | Wang Hongyun;Shen Xiyue;Tian Guoxiong;Shi Xili;Huang Wei;Wu Yongguang;Sun Lei;Peng Can;Liu Shasha;Huang Ying;Chen Xiaoyu;Zhang Fang;Chen Yingjie;Ding Wenjun;Lu Zhongbing |
| 8 | YAP promotes breast cancer metastasis by repressing growth differentiation factor-15 | 期刊论文 | Wang Ting;Mao Beibei;Cheng Chi;Zou Zhuangzhi;Gao Junling;Yang Yanglu;Lei Tong;Qi Xiaolong;Yuan Zengqiang;Xu Wentong;Lu Zhongbing |
| 9 | GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress | 期刊论文 | Feng Wei;Lei Tong;Wang Yue;Feng Run;Yuan Juntao;Shen Xiyue;Wu Yongguang;Gao Junling;Ding Wenjun;Lu Zhongbing |
| 10 | Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha 2 | 期刊论文 | Gao Junling;Yuan Juntao;Wang Qiao'e;Lei Tong;Shen Xiyue;Cui Bingqing;Zhang Fang;Ding Wenjun;Lu Zhongbing |
| 11 | 式I化合物在制备治疗肥胖及相关病症的药中的用途 | 专利 | 陆忠兵 |
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