基于序列和结构特征的人类蛋白酶底物裂解的生物信息学研究

61202167
2012
F0213.生物信息计算与数字健康
宋江宁
青年科学基金项目
研究员
中国科学院天津工业生物技术研究所
25万元
蛋白酶;底物特异性;序列分析;底物裂解位点;机器学习
2013-01-01到2015-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets 期刊论文 Tan, Hao|Akutsu, Tatsuya|Whisstock, James C.|Song, Jiangning|
2 Computational characterization of parallel dimeric and trimeric coiled-coils using effective amino acid indices. 期刊论文 Wang, Xiao-Feng|Chen, Zhen|Zhang, Ziding|Song, Jiangning|
3 Accurate in silico identification of species-specific acetylation sites by integrating protein sequence-derived and functional features. 期刊论文 Tan, Hao|Zhang, Ziding|Webb, Geoffrey I|Song, Jiangning|
4 Identifying Coevolution Between Amino Acid Residues in Protein Families Advances in the Improvement and Evaluation of Correlated Mutation Algorithms 期刊论文 Haisong Xu|Xiaoqin Li|Ziding Zhang|Jiangning Song|
5 Towards more accurate prediction of ubiquitination sites: a comprehensive review of current methods, tools and features. 期刊论文 Chen, Zhen|Zhou, Yuan|Zhang, Ziding|Song, Jiangning|
6 An integrative computational framework based on a two-step random forest algorithm improves prediction of zinc-binding sites in proteins. 期刊论文 Takemoto, Kazuhiro|Akutsu, Tatsuya|Zhang, Ziding|Song, Jiangning|
7 Predicting Protein N-Terminal Signal Peptides Using Position-Specific Amino Acid Propensities and Conditional Random Fields 期刊论文 Fan, Yong-Xian|Song, Jiangning|Xu, Chen|Shen, Hong-Bin|
8 Prediction of protein-RNA residue-base contacts using two-dimensional conditional random field with the lasso 期刊论文 Hayashida, Morihiro|Kamada, Mayumi|Song, Jiangning|Akutsu, Tatsuya|
9 Towards more accurate prediction of protein folding rates: a review of the existing Web-based bioinformatics approaches. 期刊论文 Chang, Catherine Ching Han|Tey, Beng Ti|Song, Jiangning|Ramanan, Ramakrishnan Nagasundara|
10 Bioinformatics approaches for improved recombinant protein production in Escherichia coli: protein solubility prediction 期刊论文 Catherine Ching Han Chang|Jiangning Song|BengTi Tey|Ramakrishnan Nagasundara Ramanan|
11 Towards more accurate prediction of ubiquitination sites: a comprehensive review of current methods, tools and features. 期刊论文 Chen, Zhen|Zhou, Yuan|Zhang, Ziding|Song, Jiangning|
12 hCKSAAP_UbSite: Improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties 期刊论文 Chen, Zhen|Zhou, Yuan|Song, Jiangning|Zhang, Ziding|
13 Computational enzyme design approaches with significant biological outcomes: progress and challenges. 期刊论文 Li, Xiaoman|Zhang, Ziding|Song, Jiangning|
14 GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome. 期刊论文 Webb, Geoffrey I|Zhang, Yang|Whisstock, James C|Song, Jiangning|
15 Towards more accurate prediction of protein folding rates: a review of the existing web-based bioinformatics approaches. 期刊论文 Chang, Catherine Ching Han|Tey, Beng Ti|Song, Jiangning|Ramanan, Ramakrishnan Nagasundara|
16 Structural propensities of human ubiquitination sites: accessibility, centrality and local conformation 期刊论文 Yuan Zhou|Sixue Liu|Jiangning Song|Ziding Zhang|
17 PredPPCrys: accurate prediction of sequence cloning, protein production, purification and crystallization propensity from protein sequences using multi-step heterogeneous feature fusion and selection. 期刊论文 Tan, Hao|Li, Yuan|Zhang, Ziding|Song, Jiangning|
18 Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets 期刊论文 Hao Tan|Tatsuya Akutsu|James C. Whisstock|Jiangning Song|
19 ZincExplorer: an accurate hybrid method to improve the prediction of zinc-binding sites from protein sequences 期刊论文 Wang, Yanying|Zhai, Ya-Feng|Song, Jiangning|Zhang, Ziding|
20 Recent Advances in Predicting Functional Impact of Single Amino Acid Polymorphisms A Review of Useful Features, Computational Methods and Available Tools 期刊论文 Mingjun Wang|Zhongwei Sun|Tatsuya Akutsu|Jiangning Song|
21 GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome. 期刊论文 Webb, Geoffrey I|Zhang, Yang|Whisstock, James C|Song, Jiangning|
22 Towards more accurate prediction of protein folding rates: a review of the existing Web-based bioinformatics approaches. 期刊论文 Chang, Catherine Ching Han|Tey, Beng Ti|Song, Jiangning|Ramanan, Ramakrishnan Nagasundara|
23 Accurate in silico identification of species-specific acetylation sites by integrating protein sequence-derived and functional features. 期刊论文 Tan, Hao|Zhang, Ziding|Webb, Geoffrey I|Song, Jiangning|
24 Towards more accurate prediction of protein folding rates: a review of the existing web-based bioinformatics approaches. 期刊论文 Chang, Catherine Ching Han|Tey, Beng Ti|Song, Jiangning|Ramanan, Ramakrishnan Nagasundara|
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