利用高通量测序和蛋白质组学技术寻找金属抗肿瘤配合物在细胞内的作用靶点

21778078
2017
B0706.药物化学生物学
谭彩萍
面上项目
教授
中山大学
64万元
蛋白质组学;抗肿瘤;靶点确认;高通量测序;金属配合物
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Anticancer Cyclometalated Iridium(III) Complexes with Planar Ligands: Mitochondrial DNA Damage and Metabolism Disturbance 期刊论文 Cao Jian Jun;Zheng Yue;Wu Xiao Wen;Tan Cai Ping;Chen Mu He;Wu Na;Ji Liang Nian;Mao Zong Wan
2 Real-Time Tracking of ER Turnover during ERLAD by a Rhenium Complex via Lifetime Imaging 期刊论文 Hao Liang;Ling Yu-Yi;Huang Zhi-Xin;Pan Zheng-Yin;Tan Cai-Ping;Mao Zong-Wan
3 Mitochondria-Targeted Cyclometalated Rhodium(III) Complexes: Synthesis, Characterization and Anticancer Research 期刊论文 Peng Yan-Bo;He Wei;Niu Qiang;Tao Can;Zhong Xiao-Lan;Tan Cai-Ping;Zhao Ping
4 Inhibition of Autophagic Flux by Cyclometalated Iridium(III) Complexes through Anion Transportation 期刊论文 Chen Mu He;Zheng Yue;Cai Xiong Jie;Zhang Hang;Wang Fang Xin;Tan Cai Ping;Chen Wen Hua;Ji Liang Nian;Mao Zong Wan
5 Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal-Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging 期刊论文 Zhang Dong-Yang;Zheng Yue;Zhang Hang;Sun Jing-Hua;Tan Cai-Ping;He Liang;Zhang Wei;Ji Liang-Nian;Mao Zong-Wan
6 Phosphorescent Metal Complexes as Theranostic Anticancer Agents: Combining Imaging and Therapy in a Single Molecule 期刊论文 Tan Cai-Ping;Zhong Yan-Mei;Ji Liang-Nian;Mao Zong-Wan
7 Mitochondria-Accumulating Rhenium(I) Tricarbonyl Complexes Induce Cell Death via Irreversible Oxidative Stress and Glutathione Metabolism Disturbance 期刊论文 Wang Fang Xin;Liang Jin Hao;Zhang Hang;Wang Ze Hua;Wan Qin;Tan Cai Ping;Ji Liang Nian;Mao Zong Wan
8 Folate Receptor-Targeted Theranostic IrSx Nanoparticles for Multimodal Imaging-Guided Combined Chemo-Photothermal Therapy 期刊论文 Zhang Dong-Yang;Zheng Yue;Zhang Hang;Yang Gang-Gang;Tan Cai-Ping;He Liang;Ji Liang-Nian;Mao Zong-Wan
9 Redirecting Cisplatin and Doxorubicin to Mitochondria Affords Highly Effective Platinum(IV) Prodrug Against Triple Negative Breast Cancer. 期刊论文 Muhammad Nafees;Tan Cai-Ping;Nasreen Sadia;Mao Zong-Wan
10 Acidity-responsive phosphorescent metal complexes for cancer imaging and theranostic applications 期刊论文 Hao Liang;Zhong Yan-Mei;Tan Cai-Ping;Mao Zong-Wan
11 Regulating Tumor N(6) -Methyladenosine Methylation Landscape using Hypoxia-Modulating OsS(x) Nanoparticles. 期刊论文 Zheng Yue;Ling Yuyi;Zhang Dong-Yang;Tan Cai-Ping;Zhang Hang;Yang Gang-Gang;Wang Hongsheng;Ji Liang-Nian;Mao Zong-Wan
12 Recoding the Cancer Epigenome by Intervening in Metabolism and Iron Homeostasis with Mitochondria-Targeted Rhenium(I) Complexes 期刊论文 Pan Zheng-Yin;Tan Cai-Ping;Rao Lu-Si;Zhang Hang;Zheng Yue;Hao Liang;Ji Liang-Nian;Mao Zong-Wan
13 Anion-Responsive Manganese Porphyrin Facilitates Chloride Transport and Induces Immunogenic Cell Death 期刊论文 Wang Fang-Xin;Liu Jie-Wei;Hong Xiao-Qiao;Tan Cai-Ping;Zhang Li;Chen Wen-Hua;Sadler Peter J.;Mao Zong-Wan
14 Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer 期刊论文 Muhammad Nafees;Tan Cai-Ping;Nawaz Uroosa;Wang Jie;Wang Fang-Xin;Nasreen Sadia;Ji Liang-Nian;Mao Zong-Wan
15 Photodamaging of Mitochondrial DNA to Overcome Cisplatin Resistance by a Ru(II)-Pt(II) Bimetallic Complex 期刊论文 Zheng Yue;Zhang Dong-Yang;Zhang Hang;Cao Jian-Jun;Tan Cai-Ping;Ji Liang-Nian;Mao Zong-Wan
16 Quantitative Tracking of Endoplasmic Reticulum Viscosity during Ferroptosis by an Iiridium Complex via TPPLM. 期刊论文 Hao Liang;Zhong Yan-Mei;Tan Cai-Ping;Mao Zong-Wan
17 A Tailored Multifunctional Anticancer Nanodelivery System for Ruthenium-Based Photosensitizers: Tumor Microenvironment Adaption and Remodeling 期刊论文 Liang Jin-Hao;Zheng Yue;Wu Xiao-Wen;Tan Cai-Ping;Ji Liang-Nian;Mao Zong-Wan
18 Monitoring Mitochondrial Viscosity with Anticancer Phosphorescent Ir(III) Complexes via Two-Photon Lifetime Imaging 期刊论文 Hao Liang;Li Zhi-Wei;Zhang Dong-Yang;He Liang;Liu Wen-Ting;Yang Jing;Tan Cai-Ping;Ji Liang-Nian;Mao Zong-Wan
19 Anticancer Ir(III)-Aspirin Conjugates for Enhanced Metabolic Immuno-Modulation and Mitochondrial Lifetime Imaging 期刊论文 Wu Xiao Wen;Zheng Yue;Wang Fang Xin;Cao Jian Jun;Zhang Hang;Zhang Dong Yang;Tan Cai Ping;Ji Liang Nian;Mao Zong Wan
20 Induction and Monitoring of DNA Phase Separation in Living Cells by a Light-Switching Ruthenium Complex. 期刊论文 Wang Wen-Jin;Mu Xia;Tan Cai-Ping;Wang Yu-Jian;Zhang Yuebin;Li Guohui;Mao Zong-Wan
21 Mitochondria-Targeting Monofunctional Platinum(II)-Lonidamine Conjugates for Cancer Cell De-Energization 期刊论文 Muhammad Nafees;Tan Cai-Ping;Muhammad Kamran;Wang Jie;Sadia Nasreen;Pan Zheng-Yin;Ji Liang-Nian;Mao Zong-Wan
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