【30970696】计算机模拟蒽环类抗癌药物与DNA相互作用的分子对接模型研究国家自然基金项目

计算机模拟蒽环类抗癌药物与DNA相互作用的分子对接模型研究

项目批准号： 30970696

批准年份： 2009

学科分类： C0504.物理生物学

项目负责人：崔凤灵

资助类别：面上项目

负责人职称：教授

依托单位：河南师范大学

资助金额： 28万元

关键词：相互作用;对接模型;蒽环类药物;DNA

起止时间： 2010-01-01到2012-12-31

中英文摘要
结题摘要
结题报告
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序号	标题	类型	作者
1	Calf thymus DNA binding studies of the new neodymium-naproxen complex	期刊论文	Huo, Ruina\|Xu, Guiqing\|Jiang, Xiaoying\|Ge, Yao\|Xue, Zaikun\|Cui, Fengling\|
2	1,4-二羟基-9-10-蒽醌-2-醛缩-4-氟苯基氨基硫脲探针测定生物样品中蛋白质含量的光谱法	期刊论文	安鑫\|时蕾\|郝二军\|张巍耀\|崔凤灵\|AN Xin,SHI Lei,HAO Er-jun,ZHANG Wei-yao,Cui Feng-l\|
3	N-(6-嘌呤)-蛋氨酸探针测定生物样品中蛋白质含量	期刊论文	崔凤灵\|邢卫卫\|江晓莹\|张晓丽\|程姗\|霍瑞娜\|
4	磺胺嘧啶钠探针分析生物样品中蛋白质含量的研究	期刊论文	惠广全\|贠嫣茹\|崔凤灵\|余望舒\|
5	8-溴鸟苷探针测定生物样品中蛋白质含量的光谱法研究	期刊论文	程姗\|崔凤灵\|贠嫣如\|邢卫卫\|霍瑞娜\|
6	光谱法研究ODNR与小牛胸腺DNA的相互作用	会议论文	霍瑞娜\|崔凤灵\|
7	新型柔红霉素衍生物与DNA相互作用的研究	会议论文	惠广全\|崔凤灵\|谢建平\|Guangquan Hui1,Fengling Cui1,*,Jianping Xie 2 1 Sc\|
8	硫脲新试剂探针测定唾液中蛋白质含量研究	期刊论文	刘清玲\|崔凤灵\|
9	Synthesis of biological active thiosemicarbazone and characterization of the interaction with human serum albumin	期刊论文	Yu, Wangshu\|Shi, Lei\|Hui, Guangquan\|Cui, Fengling\|
10	阿糖胞苷与人血清白蛋白相互作用的荧光法研究	会议论文	余望舒\|崔凤灵\|
11	A study on the interaction between 5-Methyluridine and human serum albumin using fluorescence quenching method and molecular modeling	期刊论文	Cui, Feng-Ling\|Yan, Ying-Hua\|Zhang, Qiang-Zhai\|Qu, Gui-Rong\|Du, Juan\|Yao, Xiao-Jun\|
12	茜素红荷移分光光度法测定阿米卡星	期刊论文	陈粤华\|孙爱丽\|冯素玲\|崔凤灵\|
13	Interaction of 2-(9H-purin-6-ylamino)-4-(methylthio) Butanoic Acid with Human Serum Albumin: Fluorescence and Modeling Studies	奖励	崔凤灵\|
14	6-氯嘌呤与人血清白蛋白的相互作用及分析应用	期刊论文	耿韶光\|贠嫣茹\|江晓莹\|崔凤灵\|郭海明\|
15	Synthesis of N-(2-chloro purin-6-yl) aza-18-crown-6 and its interaction with human serum albumin	期刊论文	Li, Cui\|Cui, Fengling\|Mao, Runze\|Huo, Ruina\|Qu, Guirong\|
16	金纳米微粒共振瑞利散射光谱法测定四环素类抗生素	期刊论文	陈粤华\|郝二军\|冯素玲\|崔凤灵\|
17	The binding characteristics of the interaction between 3-(2-cyanoethyl) cytosine and human serum albumin	期刊论文	Cui, Feng-Ling\|Hui, Guang-Quan\|Huo, Rui-Na\|Qu, Gui-Rong\|
18	Determination of bismuth in pharmaceutical products using phosphoric acid as molecular probe by resonance light scattering	期刊论文	Yun, Yanru\|Cui, Fengling\|Geng, Shaoguang\|Jin, Jianhua\|
19	DETERMINATION OF LEAD AT NANOGRAM LEVEL IN WATER SAMPLES BY RESONANCE LIGHT SCATTERING TECHNIQUE USING TETRABUTYL AMMONIUM BROMIDE AS A MOLECULAR PROBE	期刊论文	Cui, Fengling\|Yun, Yanru\|Hui, Guangquan\|Wang, Yi\|
20	Study of the Interaction of Aglycon of Daunorubicin with Human Serum Albumin by Spectroscopy and Modeling	奖励	崔凤灵\|
21	抗癌药物4'-O-(α-L-夹竹桃糖基)柔红霉素与小牛胸腺DNA的相互作用的荧光光谱	期刊论文	崔凤灵\|霍瑞娜\|张贵生\|邢卫卫\|
22	A concise approach to 1,11-didechloro-6-methyl-4’-O-demethyl rebeccemycin and its binding to human serum albumin: Fluorescence spectroscopy and molecular modeling method	奖励	崔凤灵\|
23	Investigations on the interactions of diclofenac sodium with HSA and ctDNA using molecular modeling and multispectroscopic methods	期刊论文	Yanrui Cui\|Erjun Hao\|Guangquan Hui\|Wei Guo\|Fengling Cui\|
24	Interaction of 2-(9H-purin-6-ylamino)-4-(methylthio) Butanoic Acid with Human Serum Albumin: Fluorescence and Modeling Studies	期刊论文	Cui, Fengling\|Yan, Yinghua\|Zhang, Qiangzhai\|Du, Juan\|Yao, Xiaojun\|Qu, Guirong\|Lu, Yan\|
25	快速测定生物样品中蛋白含量的同步荧光法研究	期刊论文	闫迎华\|杨艳杰\|万笑云\|崔凤灵\|张强斋\|党晓云\|渠桂荣\|
26	Study on the interaction between aglycon of daunorubicin and calf thymus DNA by spectroscopy	期刊论文	Cui, Fengling\|Huo, Ruina\|Hui, Guangquan\|Lv, Xinxin\|Jin, Jianhua\|Zhang, Guisheng\|Xing, Weiwei\|
27	光谱法研究N-丁基-N'-(对氨基苯磺酸钠)硫脲与人血清白蛋白的相互作用及其分析应用	期刊论文	崔凤灵\|霍瑞娜\|程姗\|毛润泽\|薛载坤\|
28	光谱法及分子模拟对接研究3'-脱氧-3'-叠氮阿霉素与小牛胸腺DNA的相互作用	会议论文	耿韶光\|崔凤灵\|卢雁\|
29	Fe~(3+)-H_2O_2-二氯荧光素化学发光体系测定药物中的扑热息痛	期刊论文	樊雪梅\|王书民\|尹治民\|苏智魁\|陈凤英\|王宪生\|崔凤灵\|
30	Determination of protein with Thioguanine (6-TG) as a probe by synchronous fluorescence technique	期刊论文	Hui, Guangquan1\|Zhang, Yuncheng2\|Cui, Fengling1\|Qu, Guirong1\|
31	Molecular interaction of ctDNA and HSA with sulfadiazine sodium by multispectroscopic methods and molecular modeling	期刊论文	Shaoguang Geng\|Guosheng Liu\|Wei Li\|Fengling Cui\|
32	Fluorescent investigation of the interactions between N-(p-chlorophenyl)-N’-(1-naphthyl) thiourea and serum albumin: Synchronous fluorescence determination of serum albumin	奖励	崔凤灵\|
33	Interaction of 3 '-azido-3 '-deamino daunorubicin with DNA: Multispectroscopic and molecular modeling	期刊论文	Cui, Fengling\|Hui, Guangquan\|Jiang, Xiaoying\|Zhang, Guisheng\|
34	An improved synthetic approach to 7[3-amino-4-O-(alpha-L-mycarosyl)-2,3,6-trideoxy-alpha-L-lyxo-hexopyrano syl]daunorubicinone and its interaction with human serum albumin	期刊论文	Dang, Xiaoyun\|Liu, Qingfeng\|Cui, Fengling\|Qin, Lixia\|Zhang, Guisheng\|Yao, Xiaojun\|Du, Juan\|
35	Interaction of 3 '-azido-3 '-deamino daunorubicin with human serum albumin: Investigation by fluorescence spectroscopy and molecular modeling methods	期刊论文	Lu, Yan\|Feng, Qingqin\|Cui, Fengling\|Xing, Weiwei\|Zhang, Guisheng\|Yao, Xiaojun\|
36	探针N-戊基-N′-(对氨基苯磺酸钠)硫脲快速测定血清样品中蛋白质含量的光谱法研究	期刊论文	张强斋\|贠嫣茹\|崔凤灵\|郭军霞\|
37	白藜芦醇探针同步荧光法测定蛋白质含量	期刊论文	邢卫卫\|崔凤灵\|毛润泽\|程姗\|霍瑞娜\|
38	DETERMINATION OF CINNAMIC ACID IN HUMAN URINE BY FLOW INJECTION CHEMILUMINESCENCE	期刊论文	Fan, Xuemei\|Wang, Shumin\|Su, Zhikui\|Chen, Fengying\|Liu, Yanfeng\|Liu, Ping\|Zheng, Xingwang\|Cui, Fengling\|
39	阿糖尿苷探针同步荧光法快速测定生物样品中的蛋白含量	期刊论文	余望舒\|张运成\|崔凤灵\|惠广全\|YU Wang-shu1,ZHANG Yun-cheng2,CUI Feng-ling1 and H\|2.Department of Chemical Engineering,Anyang Vocati\|
40	Spectroscopic and Molecular Modeling Studies of the Interaction Between 4 '-O-(alpha-L-Oleandrosyl)daunorubicin and Human Serum Albumin and Its Analytical Application	期刊论文	Huo, Ruina\|Li, Cui\|Cui, Fengling\|Zhang, Guisheng\|Liu, Qingfeng\|Yao, Xiaojun\|
41	邻菲啰啉-Fe(Ⅱ)光度法间接测定盐酸吡硫醇	期刊论文	过治军\|石灵\|冯素玲\|崔凤灵\|

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