双硫仑抗癌机理启发构建pH/H2O2双级响应纳米药物用于癌症的联合治疗

51903172
2019
E0308.生物医用有机高分子材料
蒲雨吉
青年科学基金项目
副研究员
四川大学
26万元
双硫仑;肿瘤微环境;联合治疗;氧化应激放大;高分子纳米药物
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Reversal of cisplatin chemotherapy resistance by glutathione-resistant copper-based nanomedicine via cuproptosis 期刊论文 Yao Lu;Qingqing Pan;Wenxia Gao;Yuji Pu;Bin He
2 Copper-based metal–organic frameworks for biomedical applications 期刊论文 Ju-E Cun;Xi Fan;Qingqing Pan;Wenxia Gao;Kui Luo;Bin He;Yuji Pu
3 Reversing Chemotherapy Resistance by a Synergy between Lysosomal pH-Activated Mitochondrial Drug Delivery and Erlotinib-Mediated Drug Efflux Inhibition 期刊论文 Furong Cheng;Qingqing Pan;Wenxia Gao;Yuji Pu;Kui Luo;Bin He
4 In-situ drug generation and controllable loading: rational design of copper-based nanosystems for chemo-photothermal cancer therapy 期刊论文 Qingqing Pan;Xinyu Peng;Ju-E Cun;Junhua Li;Yuji Pu;Bin He
5 Leveraging a polycationic polymer to direct tunable loading of an anticancer agent and photosensitizer with opposite charges for chemo-photodynamic therapy 期刊论文 Zhao Mingying;Wan Shiyu;Peng Xinyu;Zhang Boya;Pan Qingqing;Li Sai;He Bin;Pu Yuji
6 Two birds with one stone: Copper metal-organic framework as a carrier of disulfiram prodrug for cancer therapy 期刊论文 Qingqing Pan;Li Xie;Rong Liu;Yuji Pu;Di Wu;Wenxia Gao;Kui Luo;Bin He
7 Combination of PEG-decorated black phosphorus nanosheets and immunoadjuvant for photoimmunotherapy of melanoma 期刊论文 Wan Shiyu;Zhang Boya;Li Sai;He Bin;Pu Yuji
8 Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease 期刊论文 Yuji Pu;Xi Fan;Zhuangzhuang Zhang;Zhaoyuan Guo;Qingqing Pan;Wenxia Gao;Kui Luo;Bin He
9 Photo-enhanced upcycling H2O2 into hydroxyl radicals by IR780-embedded Fe3O4@MIL-100 for intense nanocatalytic tumor therapy 期刊论文 Ju-E Cun;Yang Pan;Zhuangzhuang Zhang;Yao Lu;Jiangfeng Li;Qingqing Pan;Wenxia Gao;Kui Luo;Bin He;Yuji Pu
10 Copper-olsalazine metal−organic frameworks as a nanocatalyst and epigenetic modulator for efficient inhibition of colorectal cancer growth and metastasis 期刊论文 Junhua Li;Bin He;Jing Li;Ju-E Cun;Qingqing Pan;Wenxia Gao;Kui Luo;Bin He;Zhongwei Gu;Yuji Pu
11 A reactive oxygen species-replenishing coordination polymer nanomedicine disrupts redox homeostasis and induces concurrent apoptosis-ferroptosis for combinational cancer therapy 期刊论文 Zhuangzhuang Zhang;Yang Pan;Ju-E Cun;Junhua Li;Zhaoyuan Guo;Qingqing Pan;Wenxia Gao;Yuji Pu;Kui Luo;Bin He
12 Poly(ester-thioether) microspheres co-loaded with erlotinib and alpha-tocopheryl succinate for combinational therapy of non-small cell lung cancer 期刊论文 Cheng Furong;Peng Xinyu;Meng Guolong;Pu Yuji;Luo Kui;He Bin
13 Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens 期刊论文 Yao Lu;Qingqing Pan;Wenxia Gao;Yuji Pu;Kui Luo;Bin He;Zhongwei Gu
14 Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity 期刊论文 Zhang Boya;Wan Shiyu;Peng Xinyu;Zhao Mingying;Li Sai;Pu Yuji;He Bin
15 一种水相制备高Cu(DTC)2载药量抗肿瘤蛋白纳米药物的方法 专利 蒲雨吉;潘晴晴;彭新豫;何斌
16 Polymer-directed supramolecular assembly of photosensitizers: Evocation of photothermal effect and highly efficient loading of disulfiram for chemo-phototherapy of cancer 期刊论文 Xinyu Peng;Qingqing Pan;Jing Li;Wangwei Zhu;Nan Zhang;Yuji Pu;Kui Luo;Bin He
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