以 DNA 编码分子库为工具的活细胞表面 G-蛋白偶联受体的动态修饰以及小分子拮抗剂与激动剂的研究

91953119
2019
B0704.化学遗传学
李笑宇
重大研究计划
研究员
香港大学深圳研究院
60万元
小分子与生物大分子相互作用;高通量筛选;DNA编码分子库;膜蛋白;化学遗传学
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Selection of DNA-Encoded Dynamic Chemical Libraries for Direct Inhibitor Discovery 期刊论文 Deng Yuqing;Peng Jianzhao;Xiong Feng;Song Yinan;Zhou Yu;Zhang Jianfu;Lam Fong Sang;Xie Chao;Shen Wenyin;Huang Yiran;Meng Ling;Li Xiaoyu
2 Recent advances in DNA-encoded dynamic libraries 期刊论文 Bingbing Shi;Yu Zhou;Xiaoyu Li
3 Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library 期刊论文 Zhou Yu;Shen Wenyin;Peng Jianzhao;Deng Yuqing;Li Xiaoyu
4 Selection of DNA-encoded Chemical Libraries Against Endogenous Membrane Proteins on Live Cells 期刊论文 Yiran Huang;Ling Meng;Qigui Nie;Yu Zhou;Langdong Chen;Shilian Yang;Yi Man Eva Fung;Xiaomeng Li;Cen Huang;Yan Cao;Yizhou Li;Xiaoyu Li
5 Introducing aldehyde functionality to proteins using ligand-directed affinity labeling 期刊论文 Song Yinan;Xiong Feng;Peng Jianzhao;Fung Yi Man Eva;Huang Yiran;Li Xiaoyu
6 Converting Double-Stranded DNA-Encoded Libraries (DELs) to Single-Stranded Libraries for More Versatile Selections 期刊论文 Yuhan Gui;Clara Shania Wong;Guixian Zhao;Chao Xie;Rui Hou;Yizhou Li;Gang Li;Xiaoyu Li
7 Recent Advances on the Selection Methods of DNA-encoded Libraries 期刊论文 Yiran Huang;Xiaoyu Li
8 Evolution of the Selection Methods of DNA-encoded Chemical Libraries 期刊论文 Yinan Song;Xiaoyu Li
9 Psoralen as an interstrand DNA crosslinker in the selection of DNA-Encoded dynamic chemical library 期刊论文 Yu Zhou;Jianzhao Peng;Wenyin Shen;Xiaoyu Li
10 Identification of Histone deacetylase (HDAC)-Associated Proteins with DNA-Programmed Affinity Labeling 期刊论文 Zhang Jianfu;Peng Jianzhao;Huang Yiran;Meng Ling;Li Qingrong;Xiong Feng;Li Xiaoyu
11 Selection Strategies in DNA-Encoded Libraries 专著 Yuhan Gui;Xiaoyu Li
12 Strategies for developing DNA-encoded libraries beyond binding assays 期刊论文 Yiran Huang;Yizhou Li;Xiaoyu Li
13 Future challenges with DNA-encoded chemical libraries in the drug discovery domain 期刊论文 Zhao Guixian;Huang Yiran;Zhou Yu;Li Yizhou;Li Xiaoyu
14 Direct ligand screening against membrane proteins on live cells enabled by DNA-programmed affinity labelling 期刊论文 Yiran Huang;Yuqing Deng;Jianfu Zhang;Ling Meng;Xiaoyu Li
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