用基因手段来研究内质网中GPI锚定蛋白的质量控制机制

31770853
2017
C0506.糖、脂生物化学
藤田盛久
面上项目
教授
江南大学
55万元
蛋白质折叠;糖基磷酸化肌醇化蛋白（GPI蛋白）;调控机制
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 N-Glycan-dependent protein folding and endoplasmic reticulum retention regulate GPI-anchor processing 期刊论文 Liu Yi-Shi;Guo Xin-Yu;Hirata Tetsuya;Rong Yao;Motooka Daisuke;Kitajima Toshihiko;Murakami Yoshiko;Gao Xiao-Dong;Nakamura Shota;Kinoshita Taroh;Fujita Morihisa
2 Construction of green fluorescence protein mutant to monitor STT3B-dependent N-glycosylation 期刊论文 Kitajima Toshihiko;Xue Wei;Liu Yi Shi;Wang Chun Di;Liu Si Si;Fujita Morihisa;Gao Xiao Dong
3 Global mapping of glycosylation pathways in human-derived cells 期刊论文 Huang Y. F;Aoki K;Akase S;Ishihara M;Liu Y. S;Yang G;Kizuka Y;Mizumoto S;Tiemeyer M;Gao X. D;Aoki-Kinoshita K. F;Fujita M
4 Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit 期刊论文 Liu S. S;Jin F;Liu Y. S;Murakami Y;Sugita Y;Kato T;Gao X. D;Kinoshita T;Hattori M;Fujita M
5 一种利用含硒代半胱氨酸的GPI锚定蛋白表达系统及高表达重组蛋白的细胞 专利 藤田盛久;柳艺石
6 Cell engineering for the production of hybrid-type N-glycans in HEK293 cells 期刊论文 Leng J. X.;Ren W. W.;Li Y.;Yang G.;Fujita M.
7 Selecting cells expressing high levels of recombinant proteins using the GPI-anchored protein with selenocysteine system 期刊论文 Liu Y. S;Matabaro E;Gao X. D;Fujita M
8 Structural Remodeling and Shedding of GPI-Anchors 期刊论文 Fujita Morihisa
9 Alternative routes for synthesis of N-linked glycans by Alg2 mannosyltransferase 期刊论文 Li Sheng Tao;Wang Ning;Xu Xin Xin;Fujita Morihisa;Nakanishi Hideki;Kitajima Toshihiko;Dean Neta;Gao Xiao Dong
10 MON2 Guides Wntless Transport to the Golgi through Recycling Endosomes 期刊论文 Zhao Shen-Bao;Dean Neta;Gao Xiao-Dong;Fujita Morihisa
11 用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途 专利 藤田盛久;金则成;喜多岛敏彦;张慧杰;高晓冬
12 Structural and functional analysis of Alg1 beta-1,4 mannosyltransferase reveals the physiological importance of its membrane topology 期刊论文 Xu Xin Xin;Li Sheng Tao;Wang Ning;Kitajima Toshihiko;Yoko o Takehiko;Fujita Morihisa;Nakanishi Hideki;Gao Xiao Dong
13 Glycoengineering of HEK293 cells to produce high-mannose-type N-glycan structures 期刊论文 Ren Wei-Wei;Jin Ze-Cheng;Dong Weijie;Kitajima Toshihiko;Gao Xiao-Dong;Fujita Morihisa
14 Calnexin mediates the maturation of GPI-anchors through ER retention 期刊论文 Guo X. Y;Liu Y. S;Gao X. D;Kinoshita T;Fujita M
15 Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans 期刊论文 Li Sheng Tao;Lu Tian Tian;Xu Xin Xin;Ding Yi;Li Zijie;Kitajima Toshihiko;Dean Neta;Wang Ning;Gao Xiao Dong
16 Establishment of DHFR-deficient HEK293 cells for high yield of therapeutic glycoproteins 期刊论文 Mensah Emmanuel Osei;Guo Xin-Yu;Gao Xiao-Dong;Fujita Morihisa
17 Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network 期刊论文 Zhao Shen Bao;Suda Yasuyuki;Nakanishi Hideki;Wang Ning;Yoko o Takehiko;Gao Xiao Dong;Fujita Morihisa
18 Mammalian GPI-anchor modifications and the enzymes involved 期刊论文 Liu Yi-Shi;Fujita Morihisa
19 Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles 期刊论文 Huang Y. F;MIzumoto S;Fujita M
20 Human SND2 mediates ER targeting of GPI-anchored proteins with low hydrophobic GPI attachment signals 期刊论文 Yang J;Hirata T;Liu Y. S;Guo X. Y;Gao X. D;Kinoshita T;Fujita M
21 Genetic disruption of multiple alpha1,2-mannosidases generates mammalian cells producing recombinant proteins with high-mannose-type N-glycans 期刊论文 Jin Ze-Cheng;Kitajima Toshihiko;Dong Weijie;Huang Yi-Fan;Ren Wei-Wei;Guan Feng;Chiba Yasunori;Gao Xiao-Dong;Fujita Morihisa
22 PiggyBac-based screening identified BEM4 as a suppressor to rescue growth defects in och1-disrupted yeast cells 期刊论文 Mutumwinka Diane;Zhao Shen Bao;Liu Yi Shi;Mensah Emmanuel Osei;Gao Xiao Dong;Fujita Morihisa
23 A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins 期刊论文 Liu S. S;Liu Y. S;Guo X. Y;Murakami Y;Yang G;Gao X. D;Kinoshita T;Fujita M
24 Sulfation of a FLAG tag mediated by SLC35B2 and TPST2 affects antibody recognition 期刊论文 Guo X. Y;Gao X. D;Fujita M
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