基于纹状体富集酪氨酸磷酸酶的小分子调控剂的设计与化学干预

92053105
2020
B0701.生物体系分子探针
方浩
重大研究计划
教授
山东大学
70万元
信号通路;分子探针设计;纹状体富集酪氨酸磷酸酶;阿尔茨海默症
2021-01-01到2023-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Design, synthesis and biological evaluation of hydantoin derivatives as Mcl-1 selective inhibitors 期刊论文 Xiao Liang;Xue Li;Zhiyuan Zhao;Yiming Nie;Zefu Yao;Wandi Ren;Xinying Yang;Xuben Hou;Hao Fang
2 Targeting histone deacetylases for cancer therapy: Trends and challenges 期刊论文 Tao Liang;Fengli Wang;Reham M. Elhassan;Yongmei Cheng;Xiaolei Tang;Wengang Chen;Hao Fang;Xuben Hou
3 Structure, Function and Modulation of Striatal-enriched Protein Tyrosine Phosphatase (STEP) 期刊论文 Xiao Liang;Xuben Hou;Hao Fang
4 Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors 期刊论文 Liang Tao;Xue Junxin;Yao Zefu;Ye Yang;Yang Xinying;Hou Xuben;Fang Hao
5 An in-line method for high-throughput screening of protein tyrosine phosphatase receptor type O inhibitors by capillary electrophoresis based on electrophoretically mediated microanalysis 期刊论文 Xueting Qiu;Xuben Hou;Yue Yang;Hao Fang;Fei Cui;Xinying Yang
6 Design, synthesis and bioactivity evaluations of 8-substituted-quinoline-2-carboxamide derivatives as novel histone deacetylase (HDAC) inhibitors 期刊论文 Yunpeng Zhao;Zefu Yao;Wandi Ren;Xinying Yang;Xuben Hou;Shengda Cao;Hao Fang
7 Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer 期刊论文 Hanzhi Liang;Yue Zhu;Zhiyuan Zhao;Jintong Du;Xinying Yang;Hao Fang;Xuben Hou
8 Design, synthesis and biological evaluations of novel farnesoid X receptor (FXR) agonists 期刊论文 Yuanju Zhu;Jay Zhang;Feng Min;Xinying Yang;Li Li;Yan Zhang;Xuben Hou;Hao Fang
9 Strategies to overcome drug resistance using SHP2 inhibitors 期刊论文 Meng Liu;Shan Gao;Reham M. Elhassan;Xuben Hou;Hao Fang
10 苯并呋喃类淋巴特异性酪氨酸磷酸酶抑制剂及制备方法和应用 专利 侯旭奔;方浩;梁啸
11 Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity 期刊论文 Chen Chen;Li Xue;Zhao Huajun;Liu Meng;Du Jintong;Zhang Jian;Yang Xinying;Hou Xuben;Fang Hao
12 Discovery of benzofuran-2-carboxylic acid derivatives as lymphoid tyrosine phosphatase (LYP) inhibitors for cancer immunotherapy 期刊论文 Xiao Liang;Huajun Zhao;Jintong Du;Xue Li;Kangshuai Li;Zhongcheng Zhao;Wenchao Bi;Xiaotong Zhang;Dian Yu;Jian Zhang;Hao Fang;Xuben Hou
13 Development of QSRR model for hydroxamic acids using PCA-GA-BP algorithm incorporated with molecular interaction-based features 期刊论文 Yiming Nie;Jia Li;Xinying Yang;Xuben Hou;Hao Fang
14 嘌呤胺衍生物类CDK2抑制剂及其制备方法和应用 专利 侯旭奔;赵致远;方浩;梁翰之;朱月;杜金童
15 SHP2/HDAC双靶点抑制剂及其制备方法和应用 专利 方浩;刘蒙;侯旭奔;杨新颖
16 Deciphering the Allosteric Activation Mechanism of SIRT6 Using Molecular Dynamics Simulations 期刊论文 Zhiyuan Zhao;Jintong Du;Yu Du;Yuan Gao;Mingxuan Yu;Yingkai Zhang;Hao Fang;Xuben Hou
17 Discovery of Novel Src Homology-2 Domain-Containing Phosphatase 2 and Histone Deacetylase Dual Inhibitors with Potent Antitumor Efficacy and Enhanced Antitumor Immunity. 期刊论文 Meng Liu;Shan Gao;Tao Liang;Xueting Qiu;Xinying Yang;Hao Fang;Xuben Hou
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