基于Bcl-2家族蛋白-蛋白相互作用网络研究的多靶标抗肿瘤活性化合物

81430083
2014
H34.药物学
王任小
重点项目
研究员
中国科学院上海有机化学研究所
340万元
多靶标药物;Bcl-2蛋白家族;网络药理学;小分子调控剂;蛋白-蛋白相互作用
2015-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Mechanism of Mcl-1 Conformational Regulation Upon Small Molecule Binding Revealed by Molecular Dynamic Simulation 期刊论文 Wang Anhui;Song Ting;Wang Ziqian;Liu Yubo;Fan Yudan;Zhang Yahui;Zhang Zhichao
2 Experimental Characterization of the Binding Affinities between Proapoptotic BH3 Peptides and Antiapoptotic Bcl-2 Proteins 期刊论文 Wenna Kong;Mi Zhou;Qing Li;Wenjie Fan;Haixia Lin;Renxiao Wang
3 Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl‑2 Derived from Nonselective Target Binding Ligands 期刊论文 Ziqian Wang;Zhichao Zhang
4 Substituted indole Mcl-1 inhibitors: a patent evaluation (WO2015148854A1) 期刊论文 Song Ting;Wang Ziqian;Zhang Zhichao
5 Proteome-wide identification of on- and off-targets of Bcl-2 inhibitors in native biological systems using affinity-based probes (AfBPs) 期刊论文 Ziqian Wang;Zhichao Zhang
6 AutoT&T v.2: An Efficient and Versatile Tool for Lead Structure Generation and Optimization 期刊论文 Li Yan;Zhao Zhixiong;Liu Zhihai;Su Minyi;Wang Renxiao
7 Discovery of asmall-molecule pBcl-2 inhibitor that overcomes pBcl-2-mediated resistance toapoptosis 期刊论文 Zhichao Zhang
8 Systems analysis of phosphorylation regulated Bcl 2 interactions establishes a model to reconcile the controversy over the significance of Bcl-2 phosphorylation 期刊论文 Ting Song;Zhichao Zhang
9 Discovery of selective Mcl-1 inhibitors via structure-based design and structure-activity relationship analysis 期刊论文 Nianzhe He;Zhichao Zhang
10 4‑取代萘酰亚胺类化合物及其应用 专利 张志超
11 3-氰基非那烯酮类化合物及其应用 专利 张志超
12 一种噻唑酰胺类化合物、其制备方法、药物组合物及应用 专利 王任小;俞飚;李杨峰;李嫣;徐耀春;周宓;李晴;孔文娜;李婕
13 Bcl-2/MDM2 Dual Inhibitors Based on Universal Pyramid-Like alpha-Helical Mimetics 期刊论文 Wang Ziqian;Song Ting;Feng Yingang;Guo Zongwei;Fan Yudan;Xu Wenjie;Liu Lu;Wang Anhui;Zhang Zhichao
14 A Novel Bioavailable BH3 Mimetic Efficiently Inhibits Colon Cancer via Cascade Effects of Mitochondria 期刊论文 Wang Xuefeng;Zhang Chen;Yan Xiangming;Lan Bin;Wang Jianyong;Wei Chongyang;Cao Xingxin;Wang Renxiao;Yao Jianhua;Zhou Tao;Zhou Mi;Liu Qiaoling;Jiang Biao;Jiang Pengfei;Kesari Santosh;Lin Xinjian;Guo Fang
15 Short Linear Motifs (SLiMs): New Functionally Diverse Modules Regulating Protein-protein Interactions 期刊论文 Liu Lu;Zhang Zhi-Chao
16 Fragment-Based Design, Synthesis, and Biological Evaluation of 1-Substituted-indole-2-carboxylic Acids as Selective Mcl-1 Inhibitors 期刊论文 Wang Ziqian;Xu Wenjie;Song Ting;Guo Zongwei;Liu Lu;Fan Yudan;Wang Anhui;Zhang Zhichao
17 苯基噻吩磺酰胺类化合物、药物组合物、其制备方法和应用 专利 王任小;洪然;田杰;樊文杰;李嫣;周宓;李晴;孔文娜;李扬峰;李婕
18 Structure‐based design, synthesis, and evaluation of Bcl‐2/Mcl‐1 dual inhibitors 期刊论文 Junjie Zhu;Zhichao Zhang
19 Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination 期刊论文 Song Ting;Wang Ziqian;Ji Fangling;Feng Yingang;Fan Yudan;Chai Gaobo;Li Xiangqian;Li Zhiqiang;Zhang Zhichao
20 Bcl-2 phosphorylation confers resistance on chronic lymphocytic leukaemia cells to the BH3 mimetics ABT-737, ABT-263 and ABT-199 by impeding direct binding 期刊论文 Song Ting;Chai Gaobo;Liu Yubo;Yu Xiaoyan;Wang Ziqian;Zhang Zhichao
21 Efficient synthesis of rottlerin and its two subunits 期刊论文 Li Yangfeng;Yu Biao;Wang Renxiao
22 A novel turn-on fluorescent probe for selective sensing and imaging of glutathione in live cells and organisms 期刊论文 Xiaodong Zhang;Zhichao Zhang
23 一种苯基吡唑类化合物、药物组合物、其制备方法及应用 专利 王任小;柳红;俞飚;李扬峰;李淳朴;李嫣;周宓;李晴;苏敏仪
24 Synthesis of (1,3,4-thiadiazol-2-yl)-acrylamide derivatives as potential antitumor agents against acute leukemia cells 期刊论文 Qing Li;Ran An;Yaochun Xu;Mi Zhou;Yan Li;Chun Guo;Renxiao Wang
25 Current Experimental Methods for Characterizing Protein-Protein Interactions 期刊论文 Zhou Mi;Li Qing;Wang Renxiao
26 A “Three‐in‐One” Multifunctional Probe for Bcl‐2/Mcl‐1 Profiling and Visualizing in Situ 期刊论文 Xiaodong Zhang;Zhichao Zhang
27 Efficient synthesis of baicalin and its analogs 期刊论文 Li Yang-Feng;Yu Biao;Sun Jian-Song;Wang Ren-Xiao
28 The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients 期刊论文 Zongwei Guo;Zhichao Zhang
29 硫/氧代萘酰亚胺类化合物及其应用 专利 张志超
30 一类1,5-二苯基吡唑-3-羧酸类化合物及其应用 专利 张志超
31 一种苯基噻吩磺酰胺类化合物、药物组合物、其制备方法和应用 专利 王任小;洪然;樊文杰;田杰;李嫣;周宓;李晴;孔文娜;李杨峰;李婕
32 Identification of the Apoptosis and Autophagy Bi-functional Proteins 期刊论文 Peiran Wang;Zhichao Zhang
33 Using CETSA assay and a mathematical model to reveal dual Bcl-2/Mcl-1 inhibition and on-target mechanism for ABT-199 and S1 期刊论文 Zongwei Guo;Zhichao Zhang
34 Targeting the Allosteric Pathway That Interconnects the Core- Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl‑2 期刊论文 Ziqian Wang;Zhichao Zhang
35 Identification of JNK1 as a predicting biomarker for ABT-199 and paclitaxel combination treatment 期刊论文 Ting Song;Zhichao Zhang
36 螺环吲哚酮类化合物、制备方法、药物组合物及用途 专利 王任小;吕龙;冯骁;周宓;李杨峰;李晴
37 一类非那烯酮类化合物及其应用 专利 张志超
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