α-突触核蛋白与脂质互作的结构基础及在帕金森病中的病理意义
31872716
2018
C0502.分子生物物理
刘聪
面上项目
研究员
中国科学院上海有机化学研究所
65万元
相互作用;电子衍射技术;蛋白错误折叠;脂质;帕金森病
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation | 期刊论文 | Jinxia Lu;Qin Cao;Chuchu Wang;Jing Zheng;Feng Luo;Jingfei Xie;Yichen Li;Xiaojuan Ma;Lin He;David Eisenberg;James Nowick;Lin Jiang;Dan Li |
| 2 | Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding. | 期刊论文 | Long Houfang;Zheng Weitong;Liu Yang;Sun Yunpeng;Zhao Kun;Liu Zhenying;Xia Wencheng;Lv Shiran;Liu Zhengtao;Li Dan;He Kai-Wen;Liu Cong |
| 3 | The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure. | 期刊论文 | Sun Yunpeng;Zhao Kun;Xia Wencheng;Feng Guoqin;Gu Jinge;Ma Yeyang;Gui Xinrui;Zhang Xia;Fang Yanshan;Sun Bo;Wang Renxiao;Liu Cong;Li Dan |
| 4 | The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3. | 期刊论文 | Wu Xialian;Ma Yeyang;Zhao Kun;Zhang Jing;Sun Yunpeng;Li Yichen;Dong Xingqi;Hu Hong;Liu Jing;Wang Jian;Zhang Xia;Li Bing;Wang Huayi;Li Dan;Sun Bo;Lu Junxia;Liu Cong |
| 5 | Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson's disease familial A53T mutation. | 期刊论文 | Sun Yunpeng;Hou Shouqiao;Zhao Kun;Long Houfang;Liu Zhenying;Gao Jing;Zhang Yaoyang;Su Xiao-dong;Li Dan;Liu Cong |
| 6 | Conformational change of a-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson’s disease | 期刊论文 | Yun Fan;Yunpeng Sun;Wenbo Yu;Youqi Tao;Wencheng Xia;Yiqi Liu;Qinyue Zhao;Yilin Tang;Yimin Sun;Fengtao Liu;Qin Cao;Jianjun Wu;Cong Liu;Jian Wang;Dan Li |
| 7 | Parkinson's disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure. | 期刊论文 | Zhao Kun;Li Yaowang;Liu Zhenying;Long Houfang;Zhao Chunyu;Luo Feng;Sun Yunpeng;Tao Youqi;Su Xiao-dong;Li Dan;Li Xueming;Liu Cong |
| 8 | Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders | 期刊论文 | Fan Yun;Zhao Qinyue;Xia Wencheng;Tao Youqi;Yu Wenbo;Chen Mingjia;Liu Yiqi;Zhao Jue;Shen Yan;Sun Yunpeng;Si Chenfang;Zhang Shenqing;Zhang Yaoyang;Li Wensheng;Liu Cong;Wang Jian;Li Dan |
| 9 | Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation. | 期刊论文 | Zhu Guangya;Xie Jingjing;Kong Wenna;Xie Jingfei;Li Yichen;Du Lin;Zheng Qiangang;Sun Lin;Guan Mingfeng;Li Huan;Zhu Tianxin;He Hao;Liu Zhenying;Xia Xi;Kan Chen;Tao Youqi;Shen Hong C;Li Dan;Wang Siying;Yu Yongguo;Yu Zhi-Hong;Zhang Zhong-Yin;Liu Cong;Zhu Jidong |
| 10 | Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect–based chemical-enrichment method | 期刊论文 | Qi Wang;Zhouxian Li;Shenqing Zhang;Yichen Li;Yan Wang;Zheng Fang;Yanni Ma;Zhen Liu;Weibing Zhang;Dan Li;Cong Liu;Mingliang Ye |
| 11 | Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules | 期刊论文 | Zhou Heng;Luo Feng;Luo Zhipu;Li Dan;Liu Cong;Li Xueming |
| 12 | Different Heat Shock Proteins Bind α-Synuclein With Distinct Mechanisms and Synergistically Prevent Its Amyloid Aggregation | 期刊论文 | Chunyu Jia;Xiaojuan Ma;Zhenying Liu;Jinge Gu;Xiang Zhang;Dan Li;Shengnan Zhang |
| 13 | The mouse nicotinamide mononucleotide adenylyltransferase (NMNAT) chaperones diverse pathological amyloid client proteins | 期刊论文 | Chengan Huang;Jinxia Lu;Xiaojuan Ma;Jiali Qiang;Chuchu Wang;Cong Liu;Yanshan Fang;Yaoyang Zhang;Lin Jiang;Dan Li;Shengnan Zhang |
| 14 | Structural diversity of amyloid fibrils and advances in their structure determination | 期刊论文 | Dan Li;Cong Liu |
| 15 | Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation | 期刊论文 | Yichen Li;Jinge Gu;Chen Wang;Jiaojiao Hu;Shenqing Zhang;Cong Liu;Shengnan Zhang;Yanshan Fang;Dan Li |
| 16 | Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly. | 期刊论文 | Wang Chuchu;Tu Jia;Zhang Shengnan;Cai Bin;Liu Zhenying;Hou Shouqiao;Zhong Qinglu;Hu Xiao;Liu Wenbin;Li Guohui;Liu Zhijun;He Lin;Diao Jiajie;Zhu Zheng-Jiang;Li Dan;Liu Cong |
| 17 | A high-throughput method for exploring the parameter space of protein liquid-liquid phase separation | 期刊论文 | Yichen Li;Jinge Gu;Cong Liu;Dan Li |
| 18 | Structural insights of Fe3+ induced α-synuclein fibrillation in Parkinson’s disease | 期刊论文 | Qinyue Zhao;Youqi Tao;Kun Zhao;Yeyang Ma;Qianhui Xu;Cong Liu;Shengnan Zhang;Dan Li |
| 19 | Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases | 期刊论文 | Dan Li;Cong Liu |
| 20 | Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology | 期刊论文 | Youqi Tao;Yunpeng Sun;Shiran Lv;Wencheng Xia;Zhen Huang;Qianhui Xu;Qinyue Zhao;Lin He;Weidong Le;Yong Wang;Cong Liu;Dan Li |
| 21 | Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation. | 期刊论文 | Gu Jinge;Wang Chen;Hu Rirong;Li Yichen;Zhang Shengnan;Sun Yunpeng;Wang Qiangqiang;Li Dan;Fang Yanshan;Liu Cong |
| 22 | Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology | 期刊论文 | Shengnan Zhang;Yi Zhu;Jinxia Lu;Zhenying Liu;Amanda G Lobato;Wen Zeng;Jiaqi Liu;Jiali Qiang;Shuyi Zeng;Yaoyang Zhang;Cong Liu;Jun Liu;Zhuohao He;R. Grace Zhai;Dan Li |
| 23 | Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates | 期刊论文 | Teng Wang;Jiaojiao Hu;Yanan Li;Lulu Bi;Lijuan Guo;Xinshuo Jia;Xia Zhang;Dan Li;Xi-Miao Hou;Mauro Modesti;Xu-Guang Xi;Cong Liu;BO SUN |
| 24 | The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein. | 期刊论文 | Sun Yunpeng;Long Houfang;Xia Wencheng;Wang Kun;Zhang Xia;Sun Bo;Cao Qin;Zhang Yaoyang;Dai Bin;Li Dan;Liu Cong |
| 25 | Molecular structure of an amyloid fibril formed by FUS low-complexity domain | 期刊论文 | Yunpeng Sun;Shenqing Zhang;Jiaojiao Hu;Youqi Tao;Wencheng Xia;Jinge Gu;Yichen Li;Qin Cao;Dan Li;Cong Liu |
| 26 | Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. | 期刊论文 | Gu Jinge;Liu Zhenying;Zhang Shengnan;Li Yichen;Xia Wencheng;Wang Chen;Xiang Huaijiang;Liu Zhijun;Tan Li;Fang Yanshan;Liu Cong;Li Dan |
| 27 | Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease | 期刊论文 | Li Dan;Liu Cong |
| 28 | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly | 期刊论文 | Gui Xinrui;Luo Feng;Li Yichen;Zhou Heng;Qin Zhenheng;Liu Zhenying;Gu Jinge;Xie Muyun;Zhao Kun;Dai Bin;Shin Woo Shik;He Jianhua;He Lin;Jiang Lin;Zhao Minglei;Sun Bo;Li Xueming;Liu Cong;Li Dan |
| 29 | Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM. | 期刊论文 | Zhao Kun;Lim Yeh-Jun;Liu Zhenying;Long Houfang;Sun Yunpeng;Hu Jin-Jian;Zhao Chunyu;Tao Youqi;Zhang Xing;Li Dan;Li Yan-Mei;Liu Cong |
| 30 | Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure | 期刊论文 | Xiang Li;Shenqing Zhang;Zhengtao Liu;Youqi Tao;Wencheng Xia;Yunpeng Sun;Cong Liu;Weidong Le;Bo Su;Dan Li |
| 31 | Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia | 期刊论文 | Houfang Long;Shengnan Zhang;Shuyi Zeng;Yilun Tong;Jun Liu;Cong Liu;Dan Li |
| 32 | A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism. | 期刊论文 | Tao Youqi;Xie Jingfei;Zhong Qinglu;Wang Yongyao;Zhang Shengnan;Luo Feng;Wen Fengcai;Xie Jingjing;Zhao Jiawei;Sun Xiaoou;Long Houfang;Ma Junfeng;Zhang Qian;Long Jiangang;Fang Xianyang;Lu Ying;Li Dan;Li Ming;Zhu Jidong;Sun Bo;Li Guohui;Diao Jiajie;Liu Cong |
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