以活性（抗肿瘤和抗感染）与作用机制研究为导向的硫肽类抗生素的生物合成

31430005
2014
C0102.微生物生理与生化
刘文
重点项目
研究员
中国科学院上海有机化学研究所
338万元
硫肽类抗生素;作用机制;生物活性;生物合成;组合生物合成
2015-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Metabolic Coupling of Two Small-Molecule Thiols Programs the Biosynthesis of Lincomycin A 期刊论文 Qunfei Zhao;Min Wang;Dongxiao Xu;Qinglin Zhang;Wen Liu
2 Biosynthesis of Lincosamide Antibiotics: Reactions Associated with Degradation and Detoxification Pathways Play a Constructive Role 期刊论文 Zhang Daozhong;Tang Zhijun;Liu Wen
3 万人计划 奖励 刘文
4 Isolation, Structure Elucidation, and Biosynthesis of a Cysteate-Containing Nonribosomal Peptide in Streptomyces lincolnensis 期刊论文 Wang Min;Chen Dandan;Zhao Qunfei;Liu Wen
5 A KAS-III Heterodimer in Lipstatin Biosynthesis Nondecarboxylatively Condenses C-8 and C-14 Fatty Acyl-CoA Substrates by a Variable Mechanism during the Establishment of a C-22 Aliphatic Skeleton 期刊论文 Zhang Daozhong;Zhang Fang;Liu Wen
6 1, 19-Seco-Avermectin Analogues from a ΔaveCDE Mutant Streptomyces avermectinius Strain 期刊论文 Peng Sun;Qunfei Zhao;Zhuhua Wu;Wen Zhang;Wen Liu
7 Biosynthesis of the Central Piperidine Nitrogen Heterocycle in Series a Thiopeptides 期刊论文 Liu Jingyu;Lin Zhi;Chen Hua;Guo Heng;Tao Jiang;Liu Wen
8 Processing 2-Methyl-L-Tryptophan through Tandem Transamination and Selective Oxygenation Initiates Indole Ring Expansion in the Biosynthesis of Thiostrepton 期刊论文 Zhi Lin;Jia Ji;Shuaixiang Zhou;Fang Zhang;Jiequn Wu;Yinlong Guo;Wen Liu
9 一种短链脱氢酶TsrU的功能及其应用 专利 刘文;段炼;王守锋;廖日晶
10 Discovery of New Thioviridamide-Like Compounds with Antitumor Activities 期刊论文 Li Yuqing;Liu Jingyu;Tang Haoyu;Qiu Yanping;Chen Dandan;Liu Wen
11 An Enzymatic [4+2] Cyclization Cascade Creates the Pentacyclic Core of Pyrroindomycins 期刊论文 Zhenhua Tian;Peng Sun;Yan Yan;Zhuhua Wu;Qingfei Zheng;Shuaixiang Zhou;Hua Zhang;Futao Yu;Xinying Jia;Dandan Chen;Attila Mandi;Tibor Kurtan;Wen Liu
12 Insights into the thioamidation of thiopeptins to enhance the understanding of the biosynthetic logic of thioamide-containing thiopeptides 期刊论文 Liu Jingyu;Lin Zhi;Li Yuqing;Zheng Qingfei;Chen Dandan;Liu Wen
13 Target-Oriented Design and Biosynthesis of Thiostrepton-Derived Thiopeptide Antibiotics with Improved Pharmaceutical Properties 期刊论文 Shoufeng Wang;Qingfei Zheng;Jianfeng Wang;Zhixiong Zhao;Qingye Li;Yunsong Yu;Renxiao Wang;Wen Liu
14 Recent Advances in Understanding the Enzymatic Reactions of [4+2] Cycloaddition and Spiroketalization 期刊论文 Qingfei Zheng;Zhenhua Tian;Wen Liu
15 Thiolation Protein-Based Transfer of Indolyl to a Ribosomally Synthesized Polythiazolyl Peptide Intermediate during the Biosynthesis of the Side-Ring System of Nosiheptide 期刊论文 Qiu Yanping;Du Yanan;Zhang Fang;Liao Rijing;Zhou Shuaixiang;Peng Chao;Guo Yinlong;Liu Wen
16 NosP-Regulated Nosiheptide Production Responds to Both Peptidyl and Small-Molecule Ligands Derived from the Precursor Peptide 期刊论文 Li Jingjing;Li Yue;Niu Guoqing;Guo Heng;Qiu Yanping;Lin Zhi;Liu Wen;Tan Huarong
17 Concurrent Modifications of the C-Terminus and Side Ring of Thiostrepton and Their Synergistic Effects with Respect to Improving Antibacterial Activities 期刊论文 Shoufeng Wang;Qingfei Zheng;Jianfeng Wang;Dandan Chen;Yunsong Yu;Wen Liu
18 Discovery of caerulomycin/collismycin-type 2,2-bipyridine natural products in the genomic era 期刊论文 Chen Dandan;Zhao Qunfei;Liu Wen
19 The Versatile Low-Molecular-Weight Thiols: Beyond Cell Protection 期刊论文 Min Wang;Qunfei Zhao;Wen Liu
20 Differences in PLP-Dependent Cysteinyl Processing Lead to Diverse S‑Functionalization of Lincosamide Antibiotics 期刊论文 Min Wang;Qunfei Zhao;Qinglin Zhang;Wen Liu
21 Post-Translational Modifications Involved in the Biosynthesis of Thiopeptide Antibiotics 期刊论文 Qingfei Zheng;Hui Fang;Wen Liu
22 新型硫链丝菌素类似物及其制法和用途 专利 王守锋;段炼;廖日晶;刘文
23 天然药物研究中的合成生物学 期刊论文 庞博;郑庆飞;刘文
24 Structural Insights into a Flavin-Dependent [4+2] Cyclase that Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis 期刊论文 Qingfei Zheng;Yukang Gong;Yujiao Guo;Zhixiong Zhao;Zhuhua Wu;Zixuan Zhou;Dandan Chen;Lifeng Pan;Wen Liu
25 新型硫链丝菌素类似物及其制法和用途 专利 王守锋;陈单丹;郑庆飞;刘文
26 Bio-Inspired Engineering of Thiopeptide Antibiotics Advances the Expansion of Molecular Diversity and Utility 期刊论文 Zhi Lin;Qingli He;Wen Liu
27 Biosynthesis-Based Artificial Evolution of Microbial Natural Products 期刊论文 Zhi Lin;Dandan Chen;Wen Liu
28 Biosynthesis and Molecular Engineering of Templated Natural Products 期刊论文 Ming Chen;Jingyu Liu;Panpan Duan;Mulin Li;Wen Liu
29 Precursor-Directed Mutational Biosynthesis Facilitates the Functional Assignment of Two Cytochromes P450 in Thiostrepton Biosynthesis 期刊论文 Qingfei Zheng;Shoufeng Wang;Rijing Liao;Wen Liu
30 An alpha/beta-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization 期刊论文 Zheng Qingfei;Wang Shoufeng;Duan Panpan;Liao Rijing;Chen Dandan;Liu Wen
31 Optimal design of thiostrepton-derived thiopeptide antibiotics and their potential application against oral pathogens 期刊论文 Wang Jian;Lin Zhi;Bai Xuebing;Tao Jiang;Liu Wen
32 Molecular Engineering of Thiostrepton via Single "Base"-Based Mutagenesis to Generate Side Ring-Derived Variants 期刊论文 Panpan Duan;Qingfei Zheng;Zhi Lin;Shoufeng Wang;Dandan Chen;Wen Liu
33 以生物合成为基础的红霉素A的产量提高和结构改造 期刊论文 陈单丹;吴杰群;刘文
34 4-Alkyl-l-(Dehydro)proline Biosynthesis in Actinobacteria Involves N-Terminal Nucleophile-Hydrolase Activity of g-Glutamyltranspeptidase Homolog for C-C Bond Cleavage 期刊论文 Guannan Zhong;Qunfei Zhao;Qinglin Zhang;Wen Liu
35 Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe 期刊论文 Qingfei Zheng;Qinglan Wang;Shoufeng Wang;Jiequn Wu;Qian Gao;Wen Liu
36 Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4 期刊论文 Qingfei Zheng;Yujiao Guo;Linlin Yang;Zhixiong Zhao;Zhuhua Wu;Hua Zhang;Jianping Liu;Xiaofang Cheng;Jiequn Wu;Huaiyu Yang;Hualiang Jiang;Lifeng Pan;Wen Liu
37 Radical S-Adenosylmethionine Protein NosN Forms the Side Ring System of Nosiheptide by Functionalizing the Polythiazolyl Peptide S-Conjugated lndolic Moiety 期刊论文 Qiu Yanping;Du Yanan;Wang Shoufeng;Zhou Shuaixiang;Guo Yinlong;Liu Wen
38 Cyclization of Polyketides and Non-Ribosomal Peptides on and off Their Assembly Lines 期刊论文 Bo Pang;Min Wang;Wen Liu
39 A Linear Hydroxymethyl Tetramate Undergoes an Acetylation-Elimination Process for Exocyclic Methylene Formationin the Biosynthetic Pathway of Pyrroindomycins 期刊论文 Qingfei Zheng;Zhuhua Wu;Peng Sun;Dandan Chen;Zhenhua Tian;Wen Liu
40 Enzymatic Competition and Cooperation Branch the Caerulomycin Biosynthetic Pathway Toward Different 2,2'-Bipyridine Members 期刊论文 Ming Chen;Yipeng Zhang;Yanan Du;Qunfei Zhao;Qinglin Zhang;Jiequn Wu;Wen Liu
41 Characterization of the Metallo-Dependent Amidohydrolases Responsible for "Auxiliary" Leucinyl Removal in the Biosynthesis of 2,2'-Bipyridine Antibiotics 期刊论文 Ming Chen;Bo Pang;Yanan Du;Yipeng Zhang;Wen Liu
42 高产盐屋霉素及其类似物的产生菌、盐屋霉素及其类似物的制法及其用途 专利 刘文;段盼盼
43 Molecular Engineering of Thiostrepton via Single "Base"-Based Mutagenesis to Generate Side Ring-Derived Variants 期刊论文 Panpan Duan;Qingfei Zheng;Zhi Lin;Shoufeng Wang;Dandan Chen;Wen Liu
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