链霉菌源四氢异喹啉生物碱的生物合成与抗癌新药合成生物学研究

31330003
2013
C0102.微生物生理与生化
唐功利
重点项目
研究员
中国科学院上海有机化学研究所
294万元
链霉菌;生物合成;合成生物学;四氢异喹啉生物碱;抗癌药物
2014-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis 期刊论文 Wu Long-Fei;He Hai-Yan;Pan Hai-Xue;Han Li;Wang Renxiao;Tang Gong-Li
2 Hydroxylregioisomerization of anthracycline catalyzed by a four-enzyme cascade. 期刊论文 Zhang Z.;Gong Y.-K.;Zhou Q.;Hu Y.;Ma H.-M.;Chen Y.-S.;Igarashi Y.;Pan L.;Tang G.-L.
3 双环霉素生物合成中六个氧化酶的功能及其应用 专利 唐功利;孟松;潘海学;赵娟
4 Catalysis of Extracellular Deamination by a FAD-Linked Oxidoreductase after Prodrug Maturation in the Biosynthesis of Saframycin A 期刊论文 Song Li-Qiang;Zhang Ying-Ying;Pu Jin-Yue;Tang Man-Cheng;Tang Gong-Li;Peng Chao;Tang GL
5 A six-oxidase cascade for tandem C-H bond activation revealed by reconstitution of bicyclomycin biosynthesis 期刊论文 Meng S.;Hang W.;Zhao J.;Jian X.-H.;Pan H.-X.;Tang G.-L.
6 Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis. 期刊论文 Zhang Y.;Wen W.-H.;Pu J.-Y.;Tang M.-C.;Zhang L.;Peng C.;Xu Y.;Tang G.-L.
7 An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis 期刊论文 He Hai-Yan;Yuan Hua;Tang Man-Cheng;Tang Gong-Li
8 Ferrousiron and α-ketoglutarate-dependent dioxygenases in the biosynthesis ofmicrobial natural products. 期刊论文 Wu L.-F.;Meng S.;Tang G.-L.
9 Biosynthesisof tetrahydroisoquinoline antibiotics. 期刊论文 Tang G.-L.;Tang M.-C.;Song L.-Q.;Zhang Y.
10 Cis -double bond formation by thioesterase and transfer by ketosynthase in FR901464 biosynthesis 期刊论文 He Hai-Yan;Tang Man-Cheng;Zhang Feng;Tang Gong-Li
11 天然产物生物合成与抗肿瘤药物合成生物学研究 期刊论文 潘海学;袁华;蹇晓红;唐功利
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