【30930027】准确无损地测定脑代谢物浓度和pH值的1H和31P磁共振频谱成像研究国家自然基金项目

准确无损地测定脑代谢物浓度和pH值的1H和31P磁共振频谱成像研究

项目批准号： 30930027

批准年份： 2009

学科分类： C1005.生物成像、电子与探针

项目负责人：吴仁华

资助类别：重点项目

负责人职称：教授

依托单位：汕头大学

资助金额： 164万元

关键词：脑pH值图;磁共振频谱;脑ATP图;定量检测;频谱成像

起止时间： 2010-01-01到2013-12-31

中英文摘要
结题摘要
结题报告
项目成果
项目参与人

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序号	标题	类型	作者
1	9.4T~1 H-MRS定量分析三种乳腺癌细胞的水溶性代谢物	期刊论文	张苗苗\|章杰\|徐志峰\|陈耀文\|陈义兵\|吴仁华\|
2	Quantititave analysis of brain metabolites in patients with vascular cognitive impairment no dementia	会议论文	Z. Yang\|Y. Liu\|Z. Cao\|Z. Shen\|W. Chen\|R. Wu\|
3	MR Image segmentation based on modified ant colony algorithm	会议论文	Luo, W.M\|Liu, W.W\|Shen, Z.W\|Huang, J.X\|Qui, Q.C\|Chen, Y.W\|Wu, R.H\|
4	基于体素的形态测量学观察两种亚型血管性认知障碍患者脑灰质萎缩的差异	期刊论文	沈智威, 杨忠现, 肖叶玉,\|吴仁华\|
5	Human umbilical mesenchymal stem cell and its adipogenic differentiation profiling by nuclear magnetic resonance spectroscopy.	期刊论文	Xu ZF\|Pan AZ\|Yong F\|Shen CY\|Chen YW\|Wu RH\|
6	Hippocampal Neurochemical Changes in Senescent Mice Induced with Chronic Injection of D-Galactose and NaNO2: An in vitro High-Resolution NMR Spectroscopy Study at 9.4T	期刊论文	Lin Y\|Yao JL\|Chen YW\|Pang L\|Li HH\|Cao Z\|You KZ\|Dai HY\|Wu RH\|
7	Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress	期刊论文	Wu, R\|Abdallah CG\|Chen Y\|Huang T\|Huang Q\|Xu C\|Xiao Y\|Liu Y\|Ding Y\|
8	Helical CT findings and clinicopathologic features in malignant gastrointestinal stromal tumors: the correlation between radiologic appearance and malignant potential	期刊论文	Xu ZF\|Pan AZ\|Yong F\|Chen Y\|Li B\|Gao Qiang\|Wu RH\|
9	代谢综合征患者的MR扩散张量成像研究	期刊论文	陈薇\|容宇\|杨忠现\|张尤桥\|杨杰华\|郑晓红\|吴仁华\|
10	磁共振频谱检测GABA的模拟和临床模型研究	期刊论文	林月娟\|沈智威\|肖叶玉\|邱庆春\|吴仁华\|陈耀文\|
11	Quantification of Choline Concentration Following Liver Cell Apoptosis using1 H Magnetic Resonance Spectroscopy: in vivo Rabbit Study	期刊论文	Shen ZW\|Cao Z\|You KZ\|Yang ZX\|Xiao YY\|Cheng XF\|Chen YW\|Wu RH\|
12	正常人海马短回波~1H-MRS0.5～2.05ppm区域特征性研究	期刊论文	徐志锋, 潘爱珍, 肖叶玉, 沈智威, 庞丽, 成小芳, 郭秀琴\|吴仁华\|
13	Optimized amide proton transfer imaging of ischemic stroke	会议论文	Z. Dai\|G. Yan\|S. Li\|G. Xiao\|Z. Shen\|G. Zhang\|R. Wu\|
14	Quantitative 1H-MRS of human precentral gyrus and hippocampus: absolute concentrations of metabolites	会议论文	Cheng, X.\|Wu, R. H.\|
15	颅内肿瘤磁共振波谱谷氨酸/谷氨酰胺复合物定量研究	会议论文	赵芝弘\|沈智威\|吴仁华\|
16	7.0 T MRI 体外标记 Gd-DTPA 对骨髓间充质干细胞的实验研究	期刊论文	耿宽, 贾岩龙, 黄得, 易美芝, 杨忠现, 林艳,\|吴仁华\|
17	医学影像学教学中激励医学生自主学习的探索	期刊论文	吴仁华\|肖叶玉\|黄恺\|
18	MRS双量子相干滤波技术在体检测GABA和GSH的研究现状	期刊论文	黄璜\|沈智威\|霍珊珊\|肖叶玉\|邱庆春\|吴仁华\|陈耀文\|
19	Multi-voxel MR spectroscopic study of cingulate gyrus in patients with mild cognitive impairment	会议论文	Yang Z\|Wu R\|
20	非痴呆型血管性认知功能损害和轻度认知功能损害患者颅内代谢物的定量研究	期刊论文	刘艳艳\|杨忠现\|沈智威\|曹震\|陈薇\|吴仁华\|
21	Quantitative multivoxel proton MR spectroscopy study of brain metabolites in patients with amnestic mild cognitive impairment: a pilot study	期刊论文	Wu RH\|Huo SS\|Cheng XF\|Xu ZF\|Cao Z\|Zeng JX\|Xiao YY\|You KZ\|Chen W\|
22	Metabolic Imaging of Human Brain Tumor Based on Amide Proton Transfer at 1.5 T	会议论文	Chen Y\|Wu R.\|
23	电针刺激穴位的脊髓fMRI初步研究	期刊论文	陈业晞\|沈智威\|肖叶玉\|李志扬\|吴仁华\|孔抗美\|
24	Early experience of using pH-weighted MRI to detect the ischaemic penumbra at 1.5 Tesla	会议论文	W. Yang\|Z. Shen\|G. Xiao\|R. Wu\|
25	Pharmacokinetics and bio-distribution of new Gd-complexes of DTPA-bis (amide) (L3) in a rat model	会议论文	G. Yan\|Y. Xuan\|D.S. Kang\|R. Wu\|
26	Image-guided percutaneous lipiodol-pingyangmycin suspension injection therapy for sacral chordoma	期刊论文	Huang D\|Chen Y\|Zeng Q\|Wu R\|Li Y\|
27	Pre-clinical Experiment of pH-weighted Magnetic Resonance Imaging in Human Brain Tumor at 1.5 Tesla	会议论文	Zhuozhi Dai\|Maobin Wei\|Zhiwei Shen\|Gang Xiao\|Renhua Wu\|Qingchun Qiu\|Yaowen Chen\|
28	铜代谢紊乱对脑神经系统疾病的影响	期刊论文	李琦\|张源\|易美芝\|刘少文\|庄东红\|吴仁华\|陈耀文\|
29	Measurement of extracellular-pH based iopamidol chemical exchange saturation transfer imaging at 7T	会议论文	Wang, L\|Shen, Z\|Xiao, G\|Sun, Z\|Wu, R\|
30	Quantification of brain metabolite concentration of frontal cortex and posterior cingulate gyrus in the healthy mid-life and elderly persons through proton magnetic resonance spectroscopy	会议论文	P. Zhang\|Z.W Shen\|H.Y. Dai\|*Y.Y. Xiao\|R.H. Wu\|
31	应用~1H-MRS技术结合LCmodel软件定量分析正常成人中央前回及海马脑代谢物浓度	期刊论文	成小芳\|曹震\|徐志锋\|肖叶玉\|沈智威\|庞丽\|郭绣琴\|吴仁华\|
32	Electrophysiological correlates of proactive interference in the 'Recent Probes' verbal working memory task	期刊论文	Zhang, John X.\|Wu, Renhua\|Kong, Lingyue\|Weng, Xuchu\|Du, Yingchun\|
33	Spinal Cord Functional MR Imaging OF Healthy Volunteers Using Electrical Stimulation.	会议论文	Shen Z\|Chen Y\|Xiao Y\|Wu R\|
34	Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment: A 1 H magnetic resonance spectroscopy study	期刊论文	Chen LP\|Dai HY\|Dai ZZ\|Xu CT\|Wu RH\|
35	中华中医药学会科学技术奖三等奖（第五参与）	奖励	吴仁华\|
36	AN IMPROVED LOCALLY LINEAR EMBEDDING FOR SPARSE DATA SETS	会议论文	Wen Y\|Zhou ZY\|Wang XH\|Zhang YD\|Wu RH\|
37	基于pH值敏感的磁化传递技术在1．5T磁共振成像上的研究	期刊论文	韦茂彬\|沈智威\|肖刚\|邱庆春\|陈耀文\|吴仁华\|
38	The surface fitting approach for correction of magnetisation transfer imaging bias field	会议论文	G. Xiao\|M. Wei\|Z. Dai\|R. Wu\|
39	脊髓针刺效应的f-MRI机制与脊柱影像基础的系列应用性研究	奖励	李振鹏\|王伟东\|王新家\|齐伟力\|吴仁华\|姚关峰\|陈育春\|陈业晞\|肖叶玉\|
40	Extraction methods-based analysis of the human umbilical cord mesenchymal stem cells on 9.4 T high-resolution 1H NMR spectroscopy	期刊论文	Dai HY,\|Hong BK\|Xu ZF\|Yang YP\|Chen YW\|Xiao YY\|Wu RH\|
41	Behavioral and neurochemical alterations in C57BL/6 mice exposed to cuprizone: An in vivo 1H-MRS STUDY at 7.0 T	会议论文	G. Yan\|Z. Dai\|Z. Shen\|R. Wu\|
42	Chemical Exchange Saturation Transfer (CEST) Imaging of pH	期刊论文	Zhi-wei Shen\|Lv-hao Wang\|Zhuo-zhi Dai\|Gang Xiao\|Yin Wu\|Ren-hua Wu\|
43	1H-MR Spectroscopy Quantification Using LCModel with the Simulated Basis-set Created by Software Vespa	会议论文	Qiang Xue\|Zhiwei Shen\|Hui Wang\|Yaowen Chen\|Renhua Wu\|
44	Detecting Human Mesenchymal Stem Cell Death Using 9.4T MRS	会议论文	Dai, H.Y\|Xiao, Y.Y\|Wu, R.H\|
45	Quantification of N-acetylaspartate concentration of hippocampus in vivo by multivoxel 1H MR spectroscopy: comparison with singlevoxel method	会议论文	Shen, Z. W.\|Pang, L.\|Guo, X. Q.\|Chen, X. F.\|Ning, L.\|Xu, Z.\|Chen, Y. W.\|Qiu, Q. C.\|Wu, R. H.\|
46	化学交换饱和转移在磁共振pH成像方面的应用	期刊论文	宁立波\|邱庆春\|肖叶玉\|吴仁华 (通讯作者)\|
47	设计MEGA-PRESS序列在体检测脑内γ-氨基丁酸的研究	会议论文	曾戴月\|林月娟\|沈智威\|邱庆春\|吴仁华\|陈耀文\|
48	压缩感知技术及其在 MRI 上的应用	期刊论文	张桂珊, 肖刚, 戴卓智, 沈智威, 李胜开,\|吴仁华\|
49	9.4T MRS观察人脐带间充质干细胞代谢特征	期刊论文	代海洋, 肖叶玉, 洪璧楷, 陈耀文, 谢庆东\|吴仁华\|
50	Influence of STEAM and PRESS sequences on absolute quantitation of 1H MR spectroscopy and comparison of three post-processing technologies	会议论文	Guo, X. Q.\|Xiao, Y.\|Shen, Z. W.\|Xu, Z.\|Pang, L.\|You, K.\|Ning, L.\|Wu, R. H.\|
51	The signal intensity changes of cervical spinal cord fMRI ith electrical stimulation	会议论文	Z. Shen\|Y. Chen\|W. Yang\|Y. Xiao\|
52	Advanced nasopharyngeal carcinoma radiotherapy with volumetric modulated arcs and the potential role of flattening filter-free beams	期刊论文	Zhuang, Mingzan\|Zhang, Tuodan\|Chen, Zhijian\|Lin, Zhixiong\|Li, Derui\|Peng, Xun\|Qiu, Qingchun\|Wu, Renhua\|
53	9.4T MRS观察阿尔茨海默病模型小鼠海马代谢物早期变化.	期刊论文	姚建莉, 陈耀文, 庞丽, 李海红, 尤克增, 曹震, 代海洋\|吴仁华\|
54	Study of pH-sensitive magnetisation transfer imaging in hyperacute brain infarction using a clinical 1.5 Tesla scanner	会议论文	T. Lin\|M. Wei\|G. Xiao\|Z. Shen\|P.Z. Sun\|R. Wu\|
55	应用64层螺旋CT定量局部左室功能正常参考值	期刊论文	程英\|张远芳\|金阳\|关计添\|吴仁华\|蔡新琦\|
56	The Feasibility Study of Magnetization Transfer pH Imaging at 1.5 T	会议论文	Wei, M\|Shen, Z\|Xiao, G\|Wu, R\|
57	Investigation of improved Double Quantum Coherence Filter for Localized Detection of Brain gamma-Aminobutyric Acid at 1.5T	会议论文	Huang H\|Shen ZW\|Zeng DY\|Lin Y\|Shen H\|Wu RH\|Chen YW\|
58	广东省科学技术进步奖二等奖（第三参与）	奖励	吴仁华\|
59	A fast method for determination of the parameters of pulsed-CEST MRI	会议论文	G. Xiao\|Z. Dai\|P.Z. Sun\|R. Wu\|
60	MR Spectroscopy in Metabolic Profiling Studies of Stem Cells	期刊论文	Xu ZF\|Gao MY\|Yong F\|Tian Y\|Chen YY\|Gao Q\|Ai-Zhen Pan\|Ren-Hua Wu\|
61	Investigation of pH imaging using magnetization transfer to a 1.5T clinical scanner	会议论文	Ning, L.\|Qiu, Q. C.\|Shen, Z. W.\|Wu, R. H.\|
62	Transarterial embolization using pingyangmycin lipiodol emulsion and polyvinyl alcohol for the treatment of focal nodular hyperplasia of the liver	期刊论文	Huang DX\|Chen Y\|Zeng QL\|Zhao JB\|Wu XZ\|Li YH\|Wu RH\|
63	Glutamate changes in animal models of Alzheimer's disease by means of 9.4T magnetic resonance	会议论文	Wu R\|Pang L\|
64	平山病颈椎 MRI 影像学分析	期刊论文	翟少智, 代海洋, 刘国荣, 肖叶玉, 洪璧楷,\|吴仁华\|
65	Detection of CEST MRI using magnetization Transfer pre-saturation sequence at 1.5 T scan	会议论文	Xiao, G\|Dai, Z\|Sun, P. Z\|Wu, R\|
66	A pH Regulation Mathematical Model OF The Glial Cell	会议论文	Xiao G\|Wu RH\|
67	1H-Proton Magnetic Resonance Spectroscopy Differentiates Dementia with Lewy Bodies from Alzheimer’s Disease	期刊论文	Ning YP\|Shi SH\|Shen ZW\|Hou L\|Luo XN\|Chen XR\|Liu S\|Zheng D\|Zhang YF\|
68	磁共振pH成像的研究	会议论文	吴仁华\|沈智威\|宁立波\|邱庆春\|
69	Imaging pH Phantoms Using Magnetization Transfer Technology at 1.5 Tesla	会议论文	Maobin Wei\|Zhiwei Shen\|Gang Xiao\|Qingchun Qiu\|Yaowen Chen\|Renhua Wu\|
70	Noninvasive pH imaging in human brain tumour at 1.5 Tesla	会议论文	Z.Z Dai\|M.B. Wei\|Z.W. Shen\|G. Xiao\|R.H. Wu\|
71	磁共振频谱数据定量后处理技术比较	期刊论文	郭绣琴\|肖叶玉\|沈智威\|徐志锋\|庞丽\|宁立波\|吴仁华\|
72	电针刺激脊髓损伤患者穴位的脊髓磁共振功能成像激活区特征	期刊论文	陈业晞\|沈智威\|李志扬\|肖叶玉\|吴仁华\|孔抗美\|
73	用于高场 MRS 研究的人脐带间充质干细胞代谢物提取方法选择的优化	期刊论文	代海洋, 洪璧楷, 肖叶玉, 杨玉萍, 马廉, 陈耀文,\|吴仁华\|
74	Mapping brain pH and brain ATP using multivoxel 31P MR spectroscopy: a preliminary study	会议论文	Wu, R. H.\|Chen, Y. W.\|Liu, W. W.\|Qiu, Q. C.\|terBrugge, K.\|Mikulis, D.\|
75	Detection of γ-aminobutyric acid level in vivo with MEGA-PRESS sequence at 1.5Tesla	会议论文	Daiyue Zeng\|Zhiwei Shen\|Yeyu Xiao\|HaiYang Dai\|Renhua Wu\|Yaowen Chen\|
76	7．0 T功能MR波谱动态定量检测视觉皮层代谢物对视觉刺激的反应	期刊论文	林艳, Morris Peter\|吴仁华\|
77	Metabolite Absolute Quantification in Rabbit liver by Proton Magnetic Resonance Spectroscopy	会议论文	Shen, Zhiwei\|You, Kezeng\|Yang, Zhongxian\|Chen, Yaowen\|Wu, Renhua\|
78	Vision and oxygen inhalation affect mitochontrial activity: a 31P magnetic resonance spectroscopy study	会议论文	Wu, R. H.\|Wang, H.\|Poublanc, J.\|terBrugge, K.\|Mikulis, D.\|
79	二维多体素波谱定量分析遗忘型轻度认知功能障碍患者颅内代谢物	期刊论文	刘艳艳\|杨忠现\|陈薇\|曹震\|*吴仁华\|
80	MR Spectroscopy Study of Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment with No Dementia	期刊论文	Yan-Yan Liu\|Zhong-Xian Yang\|Zhi-Wei Shen\|Ye-Yu Xiao\|Xiao-Fang Cheng\|Wei Chen\|Yao-Wen Chen\|Ren-Hua Wu\|
81	基于AMARES和QUEST的31P MRS绝对定量及比较.中国医学影像技术	期刊论文	薛强\|沈智威\|陈耀文\|David Mikulis\|吴仁华\|
82	The applications of 7T H-MRS in detecting GLU metabolism during the depression mechanism	会议论文	Y. Ding\|G. Yan\|R. Wu\|
83	MRS定量测量急性缺氧缺血脑损伤猪脑代谢物研究	期刊论文	肖叶玉, 王海玉, 沈智威, 郭育波, 陈耀文\|吴仁华\|
84	Upregulation of adenosine A2A receptors induced by atypical antipsychotics and its correlation with sensory gating in schizophrenia patients	期刊论文	Xu C\|Abdallah CG\|Wang J\|Wan X\|Liang C\|Jiang L\|Liu Y\|Huang H\|Hong X\|
85	Study of pH-sensitive magnetization transfer imaging in hyperacute brain infarction using a clinical 1.5 Tesla scanner	会议论文	Taifeng Lin\|Maobin Wei\|Gang Xiao\|Zhiwei Shen\|Renhua Wu\|Sun PZ\|Qingchun Qiu\|
86	Tracking of mesenchymal stem cells labeled with Gd-Dtpa by Mr imaging in cerebral ischemia model	会议论文	K.Geng\|DX. Huang\|RH.Wu\|
87	The 1.28 ppm biomarker: not specific for neural progenitor cells, but also in the mesenchymal stem cells and differentiated adipocytes measured by NMR spectroscopy	期刊论文	Wu RH\|Shen CY\|Zhu HQ\|Chen YW\|Wu LP\|Huang P\|Xiao YY\|Shen ZW\|Pang L\|
88	代谢综合征患者的脑MR波谱研究	期刊论文	郑晓红\|陈薇\|杨忠现\|张尤桥\|杨杰华\|容宇\|吴仁华\|
89	磁共振pH成像的研究	期刊论文	吴仁华\|沈智威\|宁立波\|邱庆春\|
90	An Mri And Proton Spectroscopy Study OF The Basal Ganglias In Children With Autism And Psychomotor Retardation	会议论文	Lee Q\|Xiao YY\|Wu RH\|
91	孤独症的神经系统研究进展	期刊论文	黎倩仪, 肖叶玉\|吴仁华\|
92	9.4T MRS characterization of human umbilical cord mesenchymal stem cells underwent death metabolism	会议论文	Y. Xiao\|H. Dai\|R.Wu\|
93	Influence of STEAM and PRESS sequences on absolute quantitation of 1H MR spectroscopy and comparison of three post-processing technologies	会议论文	Xinqin Guo\|Xiaofang Cheng\|Yeyu Xiao\|Zhiwei Shen\|Yaowen Chen\|Zhen Cao\|Renhua Wu\|
94	Tracking of mesenchymal stem cells labeled with Gd-Dtpa by Mr imaging in cerebral ischemia model	会议论文	Y.-L. Guo\|S.-J. Li\|P. Zhe Sun\|R.-H. Wu\|
95	Compressed sensing technology could accelerate MRI at 7 T.	会议论文	G. Zhang\|G. Xiao\|Z. Dai\|S. Li\|R.Wu\|
96	Accurate and Quantitative Studies on the MRS of Metabolite Concentration of Human Brain Using LCModel at 1.5 T	会议论文	Shaoqiang Xu\|Shanshan Huo\|Qingchun Qiu\|Zhiwei Shen\|Zhongxian Yang\|Renhua Wu\|Yaowen Chen\|
97	Improved measurement of labile proton concentration-weighted chemical exchange rate (kws) with experimental factor-compensated and T1-normalized quantitative chemical exchange saturation transfer (CEST) MRI	期刊论文	Wu RH\|Liu CM\|Liu PK\|Sun PZ（中方兼职教授）\|
98	Non-invasive pH-weighted magnetic resonance imaging	会议论文	Dai, Z\|Shen, Z\|Wang, L\|Sun, P. Z\|Wu, R\|
99	Evaluation of the dependence of CEST-EPI measurement on repetition time, RF irradiation duty cycle and imaging flip angle for enhanced pH sensitivity	期刊论文	Sun PZ\|Lu J\|Lu J\|Wu Y\|Wu Y\|Xiao G\|Xiao G\|Wu RH\|Wu RH\|
100	基于 9.4 T1H—MRS 和模式识别的大肠癌粪便代谢组学的研究	期刊论文	林艳, 刘成康, 沈智威, 杨菊蓉,\|吴仁华\|
101	稳定期双相情感障碍病人经丙戊酸钠治疗脑肌醇无显著意义的变化:在体磁共振频谱分析(英文)	期刊论文	吴仁华\|Silverstone PH\|林艳\|
102	MEGA-PＲESS 序列定量检测在体人脑γ －氨基丁酸浓度	期刊论文	沈智威\|曾戴月\|余泽峰\|林月娟\|吴仁华\|陈耀文\|
103	The temporal evolutions of Lac, Cr and NAA concentrations inwhole brain hyperacute ischemia rat model detected quantitatively by HPLC	会议论文	Y. Xiao\|H. Wang\|X. Cheng\|Z. Shen\|Y. Chen\|R. Wu\|
104	Study on euronal metabolic characterization in peritumoral area of C6 rat glioma using 1 h MRS at 7 T	会议论文	M. Yi\|G. Yan\|Y. Xuan\|Z. Dai\|S. Li\|R. Wu\|
105	STEAM和PRESS序列对磁共振频谱绝对定量的影响	期刊论文	郭绣琴\|肖叶玉\|沈智威\|徐志锋\|庞丽\|尤克增\|宁立波\|吴仁华\|
106	Quantitative Proton Magnetic Resonance Spectroscopy of Human Precentral Gyrus and Hippocampus: Absolute Concentrations of Metabolites.	期刊论文	Cheng XF\|Cao Z\|Ning LB\|Xiao G\|Shen ZW\|Huo SS\|Wu RH\|
107	Simultaneous determination of labile proton fraction ratio and exchange rate with irradiation radio frequency (RF) power dependent quantitative CEST MRI analysis	期刊论文	Phillip Zhe Sun\|Yu Wang\|Gang Xiao\|Renhua Wu\|
108	A primary study of quantitative multivoxel proton MR spectroscopy and diffusion tensor imaging in vascular cognitive impairment with no dementia.	会议论文	YY Liu\|ZX Yang\|ZW Shen\|W Chen\|RH Wu\|
109	Exploration of noninvasive mapping of brain pH with 31P magnetic resonance spectroscopy	会议论文	Wu RH\|Chen YW\|Ye J\|Liu WW\|Shen ZW\|Qiu QC\|terBrugge K\|Kong KM\|Mikulis DJ\|

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