外毒素B亚型差异对艰难梭菌致病性影响的研究
31970129
2019
C0108.病原细菌学
陶亮
面上项目
研究员
西湖大学
60万元
艰难梭菌感染;细菌毒素;致病机制;艰难梭菌毒素B;毒力蛋白
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Enhanced small green fluorescent proteins as a multisensing platform for biosensor development | 期刊论文 | Guo-Teng Liang;Cuixin Lai;Zejun Yue;Hanbin Zhang;Danyang Li;Zhong Chen;Xingyu Lu;Liang Tao;Fedor V. Subach;Kiryl D. Piatkevich |
| 2 | Distinctive signatures of pathogenic and antibiotic resistant potentials in the hadal microbiome | 期刊论文 | Liuqing He;Xinyu Huang;Guoqing Zhang;Ling Yuan;Enhui Shen;Lu Zhang;Xiao-Hua Zhang;Tong Zhang;Liang Tao;Feng Ju |
| 3 | Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology. | 期刊论文 | Zhenrui Pan;Yuanyuan Zhang;Jianhua Luo;Danyang Li;Yao Zhou;Liuqing He;Qi Yang;Min Dong;Liang Tao |
| 4 | TFPI binding polypeptides and uses thereof | 专利 | Liang Tao;Yanyan Li;Jianhua Luo;Qi Yang |
| 5 | Topological links in predicted protein complex structures reveal limitations of AlphaFold | 期刊论文 | Yingnan Hou;Tengyu Xie;Liuqing He;Liang Tao;Jing Huang |
| 6 | Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin. | 期刊论文 | Yao Zhou;Diyin Li;Jianhua Luo;Aizhong Chen;Xingxing Li;Zhenrui Pan;Li Wan;Liuqing He;Danyang Li;Yanyan Li;Min Dong;Liang Tao |
| 7 | Structural dynamics of the CROPs domain control stability and toxicity of Paeniclostridium sordellii lethal toxin | 期刊论文 | Yao Zhou;Xiechao Zhan;Jianhua Luo;Diyin Li;Ruoyu Zhou;Jiahao Zhang;Zhenrui Pan;Yuanyuan Zhang;Tianhui Jia;Xiaofeng Zhang;Yanyan Li;Liang Tao |
| 8 | Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions | 期刊论文 | Xingxing Li;Liuqing He;Jianhua Luo;Yangling Zheng;Yao Zhou;Danyang Li;Yuanyuan Zhang;Zhenrui Pan;Yanyan Li;Liang Tao |
| 9 | LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin | 期刊论文 | Yao Zhou;Danyang Li;Danyang Li;Aizhong Chen;Liuqing He;Jianhua Luo;Liang Tao |
| 10 | 杭州市十大青年科技英才(提名) | 奖励 | 陶亮 |
| 11 | Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive. | 期刊论文 | Daniel Henkel;Helma Tatge;Dennis Schöttelndreier;Liang Tao;Min Dong;Ralf Gerhard |
| 12 | Three-dimensional printing of soft hydrogel electronics | 期刊论文 | Yue Hui;Yuan Yao;Qilin Qian;Jianhua Luo;Hehao Chen;Zheng Qiao;Yetian Yu;Liang Tao;Nanjia Zhou |
| 13 | TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile | 期刊论文 | Jianhua Luo;Qi Yang;Xiaofeng Zhang;Yuanyuan Zhang;Li Wan;Xiechao Zhan;Yao Zhou;Liuqing He;Danyang Li;Dazhi Jin;Ying Zhen;Jing Huang;Yanyan Li;Liang Tao |
| 14 | Protocol for genome-wide CRISPR knockout screens of bacterial cytotoxins in HeLa cells | 期刊论文 | Qi Yang;Yao Zhou;Liuqing He;Yuanyuan Zhang;Liang Tao |
| 15 | Composition and method for preventing and/or treating Clostridioides difficile infections caused by clade 2 strains | 专利 | Liang Tao;Yanyan Li;Jianhua Luo |
| 16 | 杭州市西湖区“最美科技工作者” | 奖励 | 陶亮 |
| 17 | Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B. | 期刊论文 | Enhui Shen;Kangli Zhu;Danyang Li;Zhenrui Pan;Yun Luo;Qiao Bian;Liuqing He;Xiaojun Song;Ying Zhen;Dazhi Jin;Liang Tao |
| 18 | An Atypical Case of Monomicrobial Clostridioides difficile Septicemia With No Gastrointestinal Manifestations | 期刊论文 | Liqian Wang;Danyang Li;Zixi Chen;Liuqing He;Xianjun Wang;Liang Tao |
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